ID A0A674EH36_SALTR Unreviewed; 953 AA.
AC A0A674EH36;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Signal peptide, CUB and EGF-like domain-containing protein 1 {ECO:0000313|Ensembl:ENSSTUP00000107320.1};
GN Name=LOC115180172 {ECO:0000313|Ensembl:ENSSTUP00000107320.1};
OS Salmo trutta (Brown trout).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8032 {ECO:0000313|Ensembl:ENSSTUP00000107320.1, ECO:0000313|Proteomes:UP000472277};
RN [1] {ECO:0000313|Ensembl:ENSSTUP00000107320.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A674EH36; -.
DR Ensembl; ENSSTUT00000114982.1; ENSSTUP00000107320.1; ENSSTUG00000046893.1.
DR GeneTree; ENSGT00940000153185; -.
DR Proteomes; UP000472277; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00054; EGF_CA; 2.
DR Gene3D; 2.10.25.10; Laminin; 8.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR24046; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24046:SF4; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF07699; Ephrin_rec_like; 3.
DR Pfam; PF14670; FXa_inhibition; 3.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00181; EGF; 9.
DR SMART; SM00179; EGF_CA; 6.
DR SMART; SM01411; Ephrin_rec_like; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 5.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS01187; EGF_CA; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000472277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 11..51
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 291..329
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 330..370
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 763..875
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 295..305
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 953 AA; 105280 MW; C4AD00B51C2F839F CRC64;
GRAQAGEGTP DADECSEGTD DCHIDALCQN TPKSFNCICK PGYKGDGKQC EDMDECENEY
NGGCVHECIN IPGNYRCTCY DGFMLAHDGH NCLGECANGM NCMNKDHGCA HICRETPKGG
VACECRPGFE LAKNQRDCTL TCNYGNGGCQ HMCDDTDVGP VCGCHQKYAL HSDSKTCIER
DEAAIESSEF NATSIADVDK RVKRRLLMET CAVNNGGCDR TCKDTATGVR CSCPVGFTLQ
PDGKTCKDID ECQEVFNNGG CDHFCKNTVG SFECSCQKGH KLLTDERTCQ DIDECSFERT
CDHTCINYPG SFDCVCQEGY TLYGLTHCGD IDECSINNGS CEHSCVNTQG GYECLCPPGQ
KLHWNKKDCT KAVKCLPDGK PAPRAQLSCD KRGGVEVCSL SCPSNALFLA DSENSYTLSC
GVPVQPGKAP QKRNATTALL TCADTLPPPI KQKARFKVKD AKCHLRPRNK EKHRETSKPR
GPLPCTDDCQ VTFVNLKCDS SKKRRRGRKS PSKEVSHITA EFEMEMKEAS DSCNVECVRE
RMKQRLQSAM RTLRKSINKQ QFYIQFSGTE YEVAQKPALH VEQCSTGQVL RDGKCVSCGV
GTYYSGDHDQ CVVCPPGTYQ DTVGQLSCEP CPSTEGQGIA GAKNVSQCGG QCPAGQYSSD
GFRPCNPCPL GSFQPEPGRV LCFSCGGGLM TKYEGSVAFR DCEAKVHCAP GHHYNSSNHR
CIRCPAGTYQ SEFGQNYCIT CPGNTTTDFD GATNVSHCKN QVCGGELGDF TGFIESPNYP
GDYPSNVDCI WTINPPHKRR ILIVVPEIFL PIEDECGDVL VMRKSALPTS ITTYETCQTY
ERPIAFTSRS RKLWIQFKSN EGNSGKGFQV PYVTYDEDYQ QLIEDIVRDG RLYASENHQE
ILKDKKLIKA LFDVLAHPQN YFRYTAQESK DMFPRSFIKL LRSKVTRFLR PYK
//
