ID A0A674GBF6_TAEGU Unreviewed; 1319 AA.
AC A0A674GBF6;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Ubiquitin specific peptidase 19 {ECO:0000313|Ensembl:ENSTGUP00000020087.1};
GN Name=USP19 {ECO:0000313|Ensembl:ENSTGUP00000020087.1};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000020087.1, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000020087.1, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000020087.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSTGUT00000035683.1; ENSTGUP00000020087.1; ENSTGUG00000008834.2.
DR GeneTree; ENSGT00940000159085; -.
DR Proteomes; UP000007754; Chromosome 12.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd06466; p23_CS_SGT1_like; 1.
DR CDD; cd06463; p23_like; 1.
DR CDD; cd02674; Peptidase_C19R; 1.
DR Gene3D; 2.60.40.790; -; 2.
DR Gene3D; 6.10.140.2220; -; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 2.
DR InterPro; IPR007052; CS_dom.
DR InterPro; IPR008978; HSP20-like_chaperone.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR InterPro; IPR002893; Znf_MYND.
DR PANTHER; PTHR21646; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR21646:SF74; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 19; 1.
DR Pfam; PF04969; CS; 2.
DR Pfam; PF00443; UCH; 1.
DR Pfam; PF16602; USP19_linker; 1.
DR Pfam; PF01753; zf-MYND; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF144232; HIT/MYND zinc finger-like; 1.
DR SUPFAM; SSF49764; HSP20-like chaperones; 2.
DR PROSITE; PS51203; CS; 2.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
DR PROSITE; PS01360; ZF_MYND_1; 1.
DR PROSITE; PS50865; ZF_MYND_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00134}.
FT TRANSMEM 1292..1313
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 50..139
FT /note="CS"
FT /evidence="ECO:0000259|PROSITE:PS51203"
FT DOMAIN 316..418
FT /note="CS"
FT /evidence="ECO:0000259|PROSITE:PS51203"
FT DOMAIN 528..1213
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT DOMAIN 822..864
FT /note="MYND-type"
FT /evidence="ECO:0000259|PROSITE:PS50865"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 160..216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 229..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 414..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1260..1282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..192
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..467
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1319 AA; 147643 MW; 6ED22DDD1C0EAA10 CRC64;
MSSSTNAPGQ RRTSRGLDDA TNKKKQKDRA NQESKEGESP SASLRKAVCK EELLLDWKQN
ADEIIIKLNL GTGALKAEDV HADFTDTDCV VKLPDGRQWS CQFYEEIESS CSKIQCKKGN
FLQLVLQKKI PLHNWSSLLK KRKDGSKELA KGAACWENGK EKAASAELTP EELRAEGTEP
PRSRREPSNP KRAPGRSEAL GGKSPASPGT QSGPSAKRAV YLKVAPTEEE ANARVAGSTE
PSKGHSGRAS SQSCSQAALL RPCGAGTACL SWERALRPSQ WPPLPWAEMP ASPTCKEDNL
SLCGFPYSEP EPFVSLTFVK NDSYEKGNDL VVVHVYVKEI HKETSKVLFR EQDFTLVFQT
SDSNFLRLHP GCGPHTVFRW QVKLRNLIEP DQCTYNFTVS RIDVCLKKRQ SQRWGGAGGA
VGGAKVAMPT GPTPLDKNPP GSNQHPLSSK EEARTSDKEK PRVEDGALDG VAARTATEHL
AVKQEPHIPS PKPTCMVPPM THSPVSAESV EDDEDEDEKK KVCLPGFTGL VNLGNTCFMN
SVIQSLSNTR ELRDYFHDRS FESEINYNNP LGTGGRLAIG FAMLLRALWK GTHHAFQPSK
LKAIVASKAS QFTGYAQHDA QEFMAFLLDG LHEDLNRIQN KPYTETVDSD GRPDEVVAEE
AWQRHKMRND SFIVDLFQGQ YKSKLVCPMC SKVSITFDPF LYLPVPLPQK QKVLTVYYFA
KEPHKKPIKF LVSISKENSS AMEVLDSVAH SVRVKPENLR LAEVIKNHFH RMFLPSHSLD
TVSPTDLLLC FEVLSPELAK ERVVELQVQQ RSQVPSGPVA KCAACQKKQL PEDEKLKRCT
RCYRVGYCNV ACQKTHWPDH KASCRPENIG FPFLISVPES RLTYARLAQL LEGYARYSVS
VFQPPFQLGR MSPEQGLQPL HSDKLEPLAK SSCAAATSAP ELGDGDRVSS LPQEQAVPPQ
ICLCLFTAAI PGYQHTPDSL SARATQFYIT KIDSANREHK LEDKGDTTLD LTDDCSLALV
WKNNERLKEF VLVESKELEC VEDPGSASEA ARAGHFTLEQ CLNLFTKPEV LAPEEAWYCP
KCKQHREASK QLMLWRLPNV LIIQLKRFSF RSFIWRDKIN DMVDFPVRSL DLSKFCIGRK
GEQQLPVYDL YAVINHYGGM IGGHYTAYAR LPNDKNSQRS DVGWRLFDDS TVTTVDESQV
VTRYAYVLFY RRRNSPVERP LPGHPSDHRA ERTPSAEAAA SQASLIWQEL EAEEQELQLE
APQRPARNSW RPCGQKRTPG TPHHPDEGCV RYFVLATTAA IVALFLNVFY PLIYQPRWR
//
