ID A0A674GHH3_TAEGU Unreviewed; 847 AA.
AC A0A674GHH3;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 11.
DE SubName: Full=Transmembrane protein 245 {ECO:0000313|Ensembl:ENSTGUP00000022279.1};
GN Name=TMEM245 {ECO:0000313|Ensembl:ENSTGUP00000022279.1};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000022279.1, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000022279.1, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000022279.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86)
CC family. {ECO:0000256|ARBA:ARBA00009773}.
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DR AlphaFoldDB; A0A674GHH3; -.
DR Ensembl; ENSTGUT00000026613.1; ENSTGUP00000022279.1; ENSTGUG00000008086.2.
DR GeneTree; ENSGT00390000001667; -.
DR Proteomes; UP000007754; Chromosome 2.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR002549; AI-2E-like.
DR PANTHER; PTHR21716; TRANSMEMBRANE PROTEIN; 1.
DR PANTHER; PTHR21716:SF4; TRANSMEMBRANE PROTEIN 245; 1.
DR Pfam; PF01594; AI-2E_transport; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 72..96
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 103..124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 136..154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 166..192
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 212..228
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 258..275
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 365..385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 620..639
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 686..707
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 713..737
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 744..763
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 783..804
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 312..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 847 AA; 92558 MW; 364ACBE98327513E CRC64;
MADSAEPAAP AAGPAAAAAA GPAATPPGSP VGERRAGDSP GAGAAMPRLP LGGQGGAAGM
SLPRLEKPIK QAFYNTGALL FAGLCCGAAV LVYFILEAFL RPLLWAVLCG TFLHPFKTSL
TALGRRWLGR LHRSRTPVLL AALLLPICFA NYGVEALGEQ VLRRRRLLLL LGAGGPLLYG
LYCLGSSLGV QVLLAQAARI ICQGLDYFSS QWIWTLVVGY LLMVSFKWNI STERYLKAIS
VPVWIMLLFH LASVAGSWRI PVFLVIVVLM TVGMLHEQQN GKESSGAELP GQVISIAAST
IAMAISMTED ESNNEHSSQP SGSTAENDQP PQASSSFSTS SSSSSGNRQR TEIGSFLRKK
KTSDIYFVTL VWAIVIVQIW LNFWIVQLLP VPFAVWALKK SVVHFGVLNF MGNHCKSWWQ
LVENFVKERQ EALAPRPIRG LGSVMLKLDS KVHQESVHMI QVTSSLINET VASHPEWANW
LPEAQVIQKA LNSAANNVYQ YGREWITHKL HKILGEKVNN TAVIEKQVLE LWDRLYHSWF
VKNVTHSGRH KGHKWHINRQ NSWLGDILDW QDVASFVHDN IETFLSILES LWIVMSRNVS
LLFTTVTALV TILFHSGTAL LNFVLSVVIF LTTLFYLLSS SDEYYKPVKW VISLTPLSQP
GPSSNIVGQS VEEAIRGVFD ASLKMAGFYG LYTWLTHTIF GINIVFIPSA LAAILGAVPF
LGTYWAAVPA VLDLWLVQGQ GCKALLLLVF HLLPTYFVDT AIYSDISGGG HPYLTGLAVA
GGAYYLGLEG AIIGPILLCI LVVASNIYSA MLVSPTNSVP TPSQAAWPLQ IYRSPRESPE
EMKTSAE
//
