ID A0A674GLX1_TAEGU Unreviewed; 958 AA.
AC A0A674GLX1;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=Sortilin related VPS10 domain containing receptor 3 {ECO:0000313|Ensembl:ENSTGUP00000023446.1};
GN Name=SORCS3 {ECO:0000313|Ensembl:ENSTGUP00000023446.1};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000023446.1, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000023446.1, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000023446.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC subfamily. {ECO:0000256|ARBA:ARBA00010818}.
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DR AlphaFoldDB; A0A674GLX1; -.
DR Ensembl; ENSTGUT00000034606.1; ENSTGUP00000023446.1; ENSTGUG00000010448.2.
DR GeneTree; ENSGT01030000234563; -.
DR Proteomes; UP000007754; Chromosome 6.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.10.70.80; -; 1.
DR Gene3D; 3.30.60.270; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF10; VPS10 DOMAIN-CONTAINING RECEPTOR SORCS3; 1.
DR Pfam; PF00801; PKD; 1.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 1.
DR SMART; SM00602; VPS10; 1.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR SUPFAM; SSF49299; PKD domain; 2.
DR PROSITE; PS50093; PKD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 916..934
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 652..696
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
SQ SEQUENCE 958 AA; 108694 MW; 27403290E36749F7 CRC64;
ELTRVHLIPS LTLNNHSCRE VSSQNLINSW WHVILILTKL YDFNLGSVTE SSLWRSTDYG
TTYEKLNDKV GLKTVLSYLY VSPTNKRKIM LLSDPEIESS ILISSDEGAT YQKYRLNFYI
QSLLFHPKQE EWILAYSLDQ KLYSSMDFGR KWQLMHERVT PNRFYWSVTG LDKEPDLVHM
EARTADGHTH YLTCRIQECS ETKRSGPFPR SIDVSSLVVQ DEYIFIQVRW VSACPDMHII
STDENQVFAA VQEWNQNDTY NLYISDTRGV YFTLALENVK SSRGLEGNIV IDLYEVAGIK
GIFLANRKVD DQIKTFITYN KGRDWRLLQA PDTDLRGDPV LCQLPFCSLH LRLQLSENPY
TSGSISSKET APGLLVATGN IGSELSYTDV GVFISSDGGN SWRQIFEEEY NVWFLDWGGA
LVAMKHTSVP IRHMWVSFDE GRSWTKYSFT STPLFVDGSL VDPGIETQIM TVFGHFSLRS
EWQLVKVDYK SLFSHRCTKD DYQTWHLHNQ GEPCVMGERK IYKKRKPGAQ CSLSRDYSQT
VVSEPCVCGQ GDFECDYGYE RHSNNQCIPA FWFSPSSLSK DCNVGQNYWN STGYRRIVSN
NCTDGLREKY MAKMEKCPGK APRGLHILTS DGKLVMEQGH NATFIILMEE LDFGDGIAVS
YANFSPVEDG IRHVYKSAGI FQVTAYAENS LGSDTAVLFL HVVCPVEHVH LSVPFVAIRN
KDVNITAVVW PSQAGTLTYF WWFGNSTKPL ITLESSISYM FTVEGMNTVT VQVAGGNTLI
QDTKEVAVHE YFQSQLLSFS PNLDYHNPDI PEWRQDVGKV IKRALVTGIP DEQILVAVFP
GLPTSAELFI LPHKNTTERR KSSEADLEQV VEILFNALNQ NLVQFELKPG VEVVVYVTQL
TLAPLVDSSS GHSSSAMLML LSVVFVGLAV FLIYKFKRLV FSKDVSGIQT IFKIKLYD
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