ID A0A674GUF6_TAEGU Unreviewed; 1139 AA.
AC A0A674GUF6;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=Neurofilament medium polypeptide {ECO:0000256|ARBA:ARBA00015894};
DE AltName: Full=160 kDa neurofilament protein {ECO:0000256|ARBA:ARBA00030258};
DE AltName: Full=Neurofilament triplet M protein {ECO:0000256|ARBA:ARBA00032778};
GN Name=NEFM {ECO:0000313|Ensembl:ENSTGUP00000026649.1};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000026649.1, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000026649.1, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000026649.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR AlphaFoldDB; A0A674GUF6; -.
DR Ensembl; ENSTGUT00000020892.1; ENSTGUP00000026649.1; ENSTGUG00000004494.2.
DR GeneTree; ENSGT00940000161685; -.
DR InParanoid; A0A674GUF6; -.
DR OMA; TTYQDTI; -.
DR Proteomes; UP000007754; Chromosome 22.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR006821; Intermed_filament_DNA-bd.
DR PANTHER; PTHR45652; GLIAL FIBRILLARY ACIDIC PROTEIN; 1.
DR PANTHER; PTHR45652:SF3; NEUROFILAMENT MEDIUM POLYPEPTIDE; 1.
DR Pfam; PF00038; Filament; 2.
DR Pfam; PF04732; Filament_head; 1.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754}.
FT DOMAIN 234..694
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 1..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 765..1065
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 224..377
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 429..491
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..45
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 797..817
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 824..843
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 844..861
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 882..913
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 960..1004
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1021..1059
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1139 AA; 124487 MW; EBD352FA56BB7DAC CRC64;
MEGRKEGKKE RAGLGKGGEG SRARGKEHGK GKGAAGGRKE GVGAAERRGQ WVGSGEGKGE
EGAEQGGSEG SAEGEGAPGG VRAGTRRGKE GGAGAGRGAG RGEPPPARVC GAVPQPPGGA
IKGAAAARAA PHRRPQRPTM SYTMEPLGNP SYRRVTETRA TYSRASASPS SGFRSQSWSR
GSGSTVSSSY KRPNLGGPRA AYGSTVLSSA ESLDVSQSSL LNGAAELKLS RSNEKEQLQG
LNDRFAGYIE KVHYLEQQNK EIEAELAALR QKHAGRAQLS DAYEQELREL RGALEQVSHE
KAQIQLDSEH IEEDIQRLRE RFEDEARLRD ETEATIRALR KEMEEASLMR AELDKKVQSL
QDEVAFLRGN HEEEVAELLA QLQASHATVE RKDYLKTDLT TALKEIRAQL ECQSDHNMHQ
AEEWFKCRYA KLTEAAEQNK EAIRSAKEEI AEYRRQLQSK SIELESVRGT KESLERQLSD
IEERHNNDLS TYQVPGRRRG AVPCPAGGGR GRLRGEGCGR GPVGGMREVP RCPLWDGEMR
EVPALGWGDA GGARSGMRRC GKCPLWEEGC GRRPVPAPQR GMRKAGRGRR RCGGRWERVG
PALMPALPPR AAGRVSKSPL GEVLPAQSPR VCHRGFSASP LQDTIHQLEN ELRGTKWEMA
RHLREYQDLL NVKMALDIEI AAYRKLLEGE ETRFSAFSGS ITGPIFTHRQ PSVTIASTKI
QKTKIEPPKL KVQHKFVEEI IEETKVEDEK SEMEDALAAI AEEMAAKAQQ EEKEEEKAEE
AAEEEVSEKA PAEQEAAAEE EEKEEEEAEE EEEAAKSDAA EEGGSEKEEI EEKEEGEEAE
EEEEKPEAKS KAEEVPAKAE KVKTPPVKSP PKSPVTEPAK ATPKEKPAEA AKEQKAEKTE
KAAKEEEKAA SPEKPATPKV TSPEKPATPE KAVTPEKAAT PEKAVTPEKV VSPEKTVVLE
KLAPPEKPRA PEKPVSPEKP RTPEKAVTPE KPRSPEKPPS PGKDAKAVVE ETITVTKVTK
VSAEAEKESR KEDIAVNGEV EEKKEEESKE KEEEDKGVVT NGLDVSPVDD KAEKIVVTKK
AEKITGEGGD SGTTFITKSV TVTQKVEEHE ESFEEKLVST KKVEKVTSHA VVKEIKESE
//