ID A0A674MBX5_TAKRU Unreviewed; 928 AA.
AC A0A674MBX5;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=Solute carrier family 12 member 9-like {ECO:0000313|Ensembl:ENSTRUP00000058792.1};
GN Name=LOC101066717 {ECO:0000313|Ensembl:ENSTRUP00000058792.1};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000058792.1, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000058792.1, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000058792.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A674MBX5; -.
DR Ensembl; ENSTRUT00000087707.1; ENSTRUP00000058792.1; ENSTRUG00000013042.3.
DR GeneTree; ENSGT00940000164152; -.
DR Proteomes; UP000005226; Chromosome 11.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR PANTHER; PTHR11827:SF96; SOLUTE CARRIER FAMILY 12 MEMBER 9; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF03522; SLC12; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 50..74
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 86..112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 133..158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 178..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 208..229
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 282..302
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 323..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 366..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 412..429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 435..460
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 472..494
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 500..522
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 55..553
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 565..651
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 19..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 928 AA; 102406 MW; B5A110B460B65EEF CRC64;
MTERTPLLHY RLAASVNEAE VRPPPAGQAV EQPPGTSRQR SAQQRQPQKL SVFFGVVIPT
LLSMFSVVVF LRIGFVVGQA GLCQGIAMFL VAYFIICMTV LSVCAISTNG ALDAGGAYYM
ISRALGPEFG GSIGIMFFLA NVCGCALFVL GLVEAVVATF GIPEDGVVLS ASQVLPSGYW
YSLLYATAIA LLCLLVCLVG AHIYAKATFL IFLVVMVVLG TIFISFFAVG PRTITLPSSS
SPTPNLTGPA FPTTANFTGF KLETLLGNLW AEYTVDYTTG TMMTFATVFA VMFNGCTGIM
AGSNMSGELK NPSYSIPRGT ITAVIFTFII YNLLCVLVAC SCDRVLLQRD YSFLRDINIW
HPLVTIGVYC STLSAAMSNL IGASRILYAL ARDDLFGKVL SPAKKTSHSG NPWASVLISW
FLVQLVLFSG KLNTIASIVT IFFLLVYAAV DVACLALEWA SAPNFRPTFR YFTWHTCVLG
IVGCAVMMFL INAIYASASI AFMLLLLLLI HYLSPTSSWG YISQALIFHQ VRKYLLMLDV
RKDHVKFWRP QILLMVSNPR SSVGLITFIN DIKKSGLYVL GHVQLGDLNT LPSDPLQSQY
DSWLSLVDHL NIKAFVNLTL ADSVRHGIQH LLFISGLGGM RPNTLVLGFY DDSFPRDMLI
DPSMSTIQCL DHSDPSPPFD QNPPLFHFSP LRVSSERQDC GEFGDGKALG PQEYVAVIAD
AMKMLKNVVL ARYFNGFDRS EFLSPSFFSP GKRAVYVDVW PVNLLRPDSS SYVDTCSLFL
LQLACVLNMV RAWRKAKLRL FLCVEEGQSV RGSEEKLGQL LKELRIKAQV YPVPWDQQER
AEEEEEEEYV NSFPSNATRL SDNYLLAVNQ LILTTAQPAP AVRFLYLPRP PADTRRYATY
LRQLELLTQD LGPTLLIHGV TPVITTDL
//
