ID A0A674MHZ9_TAKRU Unreviewed; 1051 AA.
AC A0A674MHZ9;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=Solute carrier family 12 member 5b {ECO:0000313|Ensembl:ENSTRUP00000060716.1};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000060716.1, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000060716.1, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000060716.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A674MHZ9; -.
DR Ensembl; ENSTRUT00000069687.1; ENSTRUP00000060716.1; ENSTRUG00000011523.3.
DR GeneTree; ENSGT00940000165387; -.
DR Proteomes; UP000005226; Chromosome 3.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF54; SOLUTE CARRIER FAMILY 12 MEMBER 5; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 98..119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 131..154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 166..187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 194..215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 235..252
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 259..278
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 398..418
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 438..464
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 484..502
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 538..556
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 562..583
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 595..620
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 104..278
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 392..677
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 691..808
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 823..1051
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 71..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 936..959
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..89
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 936..954
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1051 AA; 115513 MW; 82C42CD0B137AA13 CRC64;
MTDCEEGEGG PNSQGDGIPK ESSPFINSST ASDAEKSQQY DGKNMALFEE EMDTSPMVSS
LLSSLANYSN LPTGSKEHEE AENSEEGPRP SKKPAPQLGT LMGVYLPCIQ NIFGVILFLR
MTWMVGIGGV FGSFIIVFMC CSTTMLTAIS MSAIATNGVV PAGGSYYMIS RSLGPEFGGA
VGICFYLGTT FAGAMYILGC IEILLIYIVP QAAIFKIEGL EGPEAEAALL NNMRVYGTIV
LSFMALVVFV GVKYVNKLAL VFLACVILSI VAVYAGVIKT AVDPPVFPVC ILGNRTLVSK
GYDICAKVVD IDNETVTTKL WRSFCDSEYL NATCDEYFNN NNVTEIQGIP GVTSGILAEN
LFGKYLEKGA ILEKRGLPSD VDPDGPTTNS NRYVVADITS FFTLLVGIYF PSVTGIMAGS
NRSGDLRDAQ KSIPIGTIAA ITTTSTVYMS CVVLFGACIE GVVLRDKFGE GVNGNLVIGT
LAWPSPWVIV FGSFFSTCGA GLQSLTGAPR LLQAISRDGI IPFLRVFGHG KANGEPTWAL
LLTAGICEIG IIIASLDAVA PILSMFFLMC YMFVNLACAL QTLLRTPNWR PRFKFYHWAL
SFLGMSLCLS LMFICSWYYA IVAMGIATCI YKYIEFCGAE KEWGDGIRGI SLSAARFALM
RLEEGPPHTK NWRPQILVLV SVDTEQNVEQ PRLLSLTNQL KAGKGLTIVG TSVQGTFLDS
YTEAQRADQT LCKLMEAEKV KGFPQVVVSS NLRDGTSHLI QAGGLGGLKH NTVMVSWPHK
WRQPEYHQQF RNFIEVVRET TVASMALLVP KNISSYPSNG ERFTEGHIDV WWIVHDGGML
MLLPFLLRQH KVWRKCKMRI FTVAQMDDNS IQMKKDLITF LYHLRIDAQV EVVEMHDTDI
SAYTYEKTLV MEERSQMLKQ MHLTKNEMER EVQLIQSKNA SSPTSPTGPT SPAWTDKGSA
PVLLNPEVGK DLFNMKPNQV DVRRMHTAVR LNEVIIKKSK EAKLVLLNMP GPPRNRVGNE
NYMAFLEVLT EGLNRVLLVR GGGREVITIY S
//