ID A0A674MIQ3_TAKRU Unreviewed; 885 AA.
AC A0A674MIQ3;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=Signal peptide, CUB domain and EGF like domain containing 2 {ECO:0000313|Ensembl:ENSTRUP00000060966.1};
GN Name=scube2 {ECO:0000313|Ensembl:ENSTRUP00000060966.1};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000060966.1, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000060966.1, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000060966.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A674MIQ3; -.
DR Ensembl; ENSTRUT00000085967.1; ENSTRUP00000060966.1; ENSTRUG00000017398.3.
DR GeneTree; ENSGT00940000153185; -.
DR Proteomes; UP000005226; Chromosome 13.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00054; EGF_CA; 4.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 1.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR24046; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24046:SF3; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF14670; FXa_inhibition; 4.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00181; EGF; 9.
DR SMART; SM00179; EGF_CA; 7.
DR SMART; SM01411; Ephrin_rec_like; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 4.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 5.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01187; EGF_CA; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..885
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025345698"
FT DOMAIN 17..57
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 101..137
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 296..336
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 337..375
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 697..809
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 341..351
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 885 AA; 99373 MW; 52B6713608A3E370 CRC64;
MGAIWAARDL CLFLLLLNNP CAEGSDGCHI DAICQSTHGS YKCTCKAGFK GDGHHCEDID
ECDLESNGGC VHECNNIPGN YRCTCYDGFH LPCHSLCCLL DVDECKFNNG GCQHICVNTM
GSYECRCKDG FFLSDNQHTC IHRSVEGLSC MNKEHGCAHI CKETPKGGVA CECRPGFELA
RNQRDCILTC NHGNGGCQHT CEDTENGPIC RCHLRYTLQP DKRSCVERDE ASTDTSEHNS
TSFTEVDKRV KRRLLMETCA VNNGGCDCTC KDTSTGVRCS CPVGFTLQPD GKTCKDIDEC
ELHNGGCEHF CRNTIGSFEC NCRKGFKLLT DERSCQDIDE CFFERTCDHT CVNSPGGFQC
LCNKGYTLYG LAHCGDINEC SVNNGGCEHG CENSVGGFEC FCHPGYKLHW NKKDCIGKPS
WFMRGESAER CRLVQQSVKF FFTENVQFSY VRLRCTSSGQ KTRSRHGRKA GEEDGSSIMA
EFELDVNLEE VTAESCDLSC VRRRSEKRLR KTIRTLRKSI NREQFHLHFA GSDYELGKSQ
SQPAELPGHC VTGQVLIGRK CVSCGAGTHY DGDQGRCVLC PAGTYQDEEG QMSCEVCPGP
EGREVSKVVG ARNMSECGGE TRECETKGKK VTNPPPRTLF RVLPMYKSLM LPRTLLRHQH
APLHPLPDGH VPGGVRTELL QIPNYLTRAC HFADRQCGGE LGDFTGYIES PNYPGNYPAN
VECTWTINPP PKRRILIVVP EIYLPIEDEC GDYLVMRKSS LSNSVTTYET CQTYERPIAF
TSRSKRLWIQ FRSNEGNSGK GFQVPYVTYD EDYQELIEDI VRDGRLYASE NHQEILKDKK
LMKALFDVLA HPQNFFNYTA QESREMFPKS FIRFLRSKVL RFLRP
//
