GenomeNet

Database: UniProt
Entry: A0A674MP93_TAKRU
LinkDB: A0A674MP93_TAKRU
Original site: A0A674MP93_TAKRU 
ID   A0A674MP93_TAKRU        Unreviewed;       941 AA.
AC   A0A674MP93;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   24-JAN-2024, entry version 14.
DE   RecName: Full=FERM, ARHGEF and pleckstrin domain-containing protein 1 {ECO:0000256|ARBA:ARBA00040395};
DE   AltName: Full=FERM, RhoGEF and pleckstrin domain-containing protein 1 {ECO:0000256|ARBA:ARBA00042170};
GN   Name=FARP1 {ECO:0000313|Ensembl:ENSTRUP00000062946.1};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000062946.1, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000062946.1, ECO:0000313|Proteomes:UP000005226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA   Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu facilitates
RT   insights into distinct features of genome evolution in teleosts and
RT   mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000062946.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell projection, dendrite
CC       {ECO:0000256|ARBA:ARBA00004279}. Cell projection, dendritic spine
CC       {ECO:0000256|ARBA:ARBA00004552}. Cell projection, filopodium
CC       {ECO:0000256|ARBA:ARBA00004486}. Cytoplasm, cytosol
CC       {ECO:0000256|ARBA:ARBA00004514}. Synapse, synaptosome
CC       {ECO:0000256|ARBA:ARBA00034102}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A674MP93; -.
DR   Ensembl; ENSTRUT00000087389.1; ENSTRUP00000062946.1; ENSTRUG00000017356.3.
DR   GeneTree; ENSGT00940000155318; -.
DR   Proteomes; UP000005226; Chromosome 1.
DR   GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR   GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   CDD; cd14473; FERM_B-lobe; 1.
DR   CDD; cd13193; FERM_C_FARP1-like; 1.
DR   CDD; cd17189; FERM_F1_FARP1; 1.
DR   CDD; cd13235; PH2_FARP1-like; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.80.10; -; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR   InterPro; IPR019749; Band_41_domain.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR000798; Ez/rad/moesin-like.
DR   InterPro; IPR014847; FA.
DR   InterPro; IPR041788; FARP1/FARP2/FRMD7_FERM_C.
DR   InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR   InterPro; IPR035963; FERM_2.
DR   InterPro; IPR019748; FERM_central.
DR   InterPro; IPR019747; FERM_CS.
DR   InterPro; IPR000299; FERM_domain.
DR   InterPro; IPR018979; FERM_N.
DR   InterPro; IPR018980; FERM_PH-like_C.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR45858; FERM DOMAIN CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR45858:SF2; FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 1; 1.
DR   Pfam; PF08736; FA; 1.
DR   Pfam; PF09380; FERM_C; 1.
DR   Pfam; PF00373; FERM_M; 1.
DR   Pfam; PF09379; FERM_N; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   PRINTS; PR00935; BAND41.
DR   PRINTS; PR00661; ERMFAMILY.
DR   SMART; SM00295; B41; 1.
DR   SMART; SM01195; FA; 1.
DR   SMART; SM01196; FERM_C; 1.
DR   SMART; SM00233; PH; 2.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 3.
DR   SUPFAM; SSF47031; Second domain of FERM; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS00660; FERM_1; 1.
DR   PROSITE; PS50057; FERM_3; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 2.
PE   4: Predicted;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Synapse {ECO:0000256|ARBA:ARBA00023018};
KW   Synaptosome {ECO:0000256|ARBA:ARBA00022599}.
FT   DOMAIN          43..323
FT                   /note="FERM"
FT                   /evidence="ECO:0000259|PROSITE:PS50057"
FT   DOMAIN          455..643
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          672..758
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          828..925
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          781..802
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        786..800
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   941 AA;  107530 MW;  F7702515E4C1A246 CRC64;
     MAEPDPEPIA FGAGQRLGAP ETLGISTLDP AHRPPAMPPG RHVTVRVRML DDTEELFDVS
     QKASGKVLLD LVCSHMNLIE GDYFGLEFQN HQKIIVWLDH IKPIIKQLRR PKHTILRFAV
     KFFPPDHAQL LEELTRYLFA LQIKQDISSG RLTCNDTSAA LMVSHIVQSE IGDFEESKCR
     SHLLNNNYIP DQMPLIDKIM DFHSRHIGQT PAESDYQLLE VARRLEMYGI RLHPAKDREG
     TRLSLTVAHT GVLVFQGHTK INSFNWAKVR KLSFKRKRFL IKLRPDLNSS YQDTLEFLMA
     SRDCCKVFWK ICVEYHAFFR LYEEPKRKPK PVLFTRGSSF RFSGRTQKQV IDYVKESEFK
     KIPFESVDLL PVFTCFTHFF VSHSNVGAGS NSPCLSASAC HPHGMVNGQK SLELCGHSPG
     GRQPSPLTSP LLNDAGSIRT DDEDEVRRKR FPTDQAYFIA KELLTTERTY VKDLEVVTVS
     FQNAVGQEEA TPDSLKKSIF SIFEPLHKFH TGFLREVEQR LALWEGRSNA HIKGDSQRIG
     DVMLKNLQPL TVSLHKQSEA LLELEKACRS CPRLEDLCRD FELQKVCYIP LNVFILRPLH
     RLIHYKQILE RLCKHYPATH VDFRDCRAAL ADVSEVVEQL QGSLIKMENF QKLLELKKDL
     TGIDNLVVPG REFIRLGCLS KLSGKGLQQR MFFLVPSRCS VMFFPCRPMF LLQIRESEDE
     WGVPHAFTLV GQQQSVVVAA SSLAEMQKWM EDIRVAIETA KTTNGSNGFL TFPECPEDSA
     VEAESEDETA ASQTSLERPA PHRGNTMVHV CWHRNTSVSM VDFSVAVENQ LSGNLLRKFK
     NSNGWQKLWV VFTNFSLFFY KSHQDDYPLA SLPLLGYSVS VPSDSENIHK DYVFKLHFKS
     HIYYFRSESE YTFERWMEVI RSATLSSSGA RGPSNKESRP H
//
DBGET integrated database retrieval system