ID A0A674MR27_TAKRU Unreviewed; 1019 AA.
AC A0A674MR27;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Signal peptide, CUB domain and EGF like domain containing 1 {ECO:0000313|Ensembl:ENSTRUP00000063573.1};
GN Name=scube1 {ECO:0000313|Ensembl:ENSTRUP00000063573.1};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000063573.1, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000063573.1, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000063573.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_011611424.1; XM_011613122.1.
DR AlphaFoldDB; A0A674MR27; -.
DR Ensembl; ENSTRUT00000077393.1; ENSTRUP00000063573.1; ENSTRUG00000009135.3.
DR GeneID; 101078634; -.
DR CTD; 80274; -.
DR GeneTree; ENSGT00940000153185; -.
DR InParanoid; A0A674MR27; -.
DR OrthoDB; 5477406at2759; -.
DR Proteomes; UP000005226; Chromosome 18.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00054; EGF_CA; 3.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR24046; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24046:SF4; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF07699; Ephrin_rec_like; 3.
DR Pfam; PF14670; FXa_inhibition; 3.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00181; EGF; 10.
DR SMART; SM00179; EGF_CA; 7.
DR SMART; SM01411; Ephrin_rec_like; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 5.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1019
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025517853"
FT DOMAIN 31..71
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 114..150
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 351..389
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 829..941
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT REGION 520..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 355..365
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1019 AA; 112412 MW; 1386534541C0FC71 CRC64;
MGTTCCFSLD VCLFLLLINS CRLMGTTGPA DVDECSEGSD DCHIDALCQN TLKSFNCICK
PGYKGDGKQC EDMDECENDY NGGCVHECIN IPGNYRCTCY DGFMLAHDGH NCLDVDECKD
NNGGCQQVCV NTMGSYECQC TDGFFLSDNQ HTCIHRSDDG MNCMNKDHGC AHICREAPGK
GGVSCECRPG FELAKNQKDC TLTCNYGNGG CQHTCDDTDT GPVCGCHQKY ALHSDSKTCI
EKDEAAIESS EFNATSVADV DKRVKRRLLM ETCAVNNGGC DRTCKDTATG VRCSCPVGFT
LQPDGKTCKD IDECLENNGG CDQFCRNTVG SFECSCQKGH KLLTDERTCQ DIDECSFERT
CDHTCVNYPG SFQCLCKKGY ILYGLTHCGD VDECSINNGS CEHACVNTQG SYECVCPAAQ
KLHWNKKDCV EVVKCQSDGK PAPRAQLTCT KSGGAEVCSL SCPSNALFLA ESENSYTLSC
GVPLHPGKTP QKRNATTSCA ADTLAPPIKQ KAKFKIKDAK CHLRPRNKDR NKDSSGQNQQ
GAHFPCTDDC QVTFVNLKCD SSKKRRRGRK SPTKEVSHIT AEFEVEMKEE ETSDSCNVDC
VREKLKQKLQ GAMRTLRKSI NKQQFYIQFS GTEYEVAQKP SKGPEGVEAC STGQVLQDGK
CVSCSVGTFY SGEQEQCIQC PPGTYQDTVG QLSCEPCPSS EGQGITGAKN VSQCGGQCPA
GHFSVDGFRP CRLCPLGLYQ PEPGRVLCFS CGGGLMTKYE GSVSFRDCEA KVHCAPGHYY
NSSTHRCIRC PAGTYQSEFG QNYCITCPGN TTTDFDGATN VSHCKNQLCG GELGEYTGYI
ESPNYPGDYP SNVDCVWTIN PPHKRRILIV VPEIFLPIED ECGDVLVMRK SALPTSITTY
ETCQTYERPI AFTSRSRKLW IQFKSNEGNS GKGFQVPYVT YDEDYQQLIE DIVRDGRLYA
SENHQEILKD KKLIKALFDV LAHPQNYFKY TAQESKEMFP RSFIKLLRSK VTRFLRPYK
//
