ID   A0A674N5F1_TAKRU        Unreviewed;       900 AA.
AC   A0A674N5F1;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   27-MAR-2024, entry version 13.
DE   SubName: Full=Huntingtin interacting protein 1 {ECO:0000313|Ensembl:ENSTRUP00000068953.1};
GN   Name=hip1 {ECO:0000313|Ensembl:ENSTRUP00000068953.1};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000068953.1, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000068953.1, ECO:0000313|Proteomes:UP000005226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA   Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu facilitates
RT   insights into distinct features of genome evolution in teleosts and
RT   mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000068953.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the SLA2 family.
CC       {ECO:0000256|ARBA:ARBA00010135}.
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DR   AlphaFoldDB; A0A674N5F1; -.
DR   Ensembl; ENSTRUT00000087435.1; ENSTRUP00000068953.1; ENSTRUG00000005542.3.
DR   GeneTree; ENSGT00940000153594; -.
DR   Proteomes; UP000005226; Chromosome 11.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR   GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR   GO; GO:0006897; P:endocytosis; IEA:InterPro.
DR   Gene3D; 1.20.5.1700; -; 1.
DR   Gene3D; 1.25.40.90; -; 1.
DR   Gene3D; 6.10.250.920; -; 1.
DR   Gene3D; 1.20.1410.10; I/LWEQ domain; 1.
DR   InterPro; IPR011417; ANTH_dom.
DR   InterPro; IPR013809; ENTH.
DR   InterPro; IPR008942; ENTH_VHS.
DR   InterPro; IPR032422; HIP1_clath-bd.
DR   InterPro; IPR035964; I/LWEQ_dom_sf.
DR   InterPro; IPR002558; ILWEQ_dom.
DR   InterPro; IPR030224; Sla2_fam.
DR   PANTHER; PTHR10407; HUNTINGTIN INTERACTING PROTEIN 1; 1.
DR   PANTHER; PTHR10407:SF14; HUNTINGTIN-INTERACTING PROTEIN 1; 1.
DR   Pfam; PF07651; ANTH; 1.
DR   Pfam; PF16515; HIP1_clath_bdg; 1.
DR   Pfam; PF01608; I_LWEQ; 1.
DR   SMART; SM00273; ENTH; 1.
DR   SMART; SM00307; ILWEQ; 1.
DR   SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR   SUPFAM; SSF109885; I/LWEQ domain; 1.
DR   PROSITE; PS50942; ENTH; 1.
DR   PROSITE; PS50945; I_LWEQ; 1.
PE   3: Inferred from homology;
KW   Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226}.
FT   DOMAIN          9..143
FT                   /note="ENTH"
FT                   /evidence="ECO:0000259|PROSITE:PS50942"
FT   DOMAIN          634..875
FT                   /note="I/LWEQ"
FT                   /evidence="ECO:0000259|PROSITE:PS50945"
FT   REGION          881..900
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          354..458
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          483..510
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   900 AA;  101116 MW;  FEEABAF63C4300F8 CRC64;
     MLQNVRAHFL IPLSPPQVIS INKAINTQEV AVKENHPSLT PSPSPCILGT HHEKGAHTFW
     AAVTRLPLSS NAVLCWKFCH VFHKLLRDGH PNVIKDSMRN KADLTDMSRM WGHLSEGYGK
     LCSIYLKLLI TKMEFHIKNP RFPGNLQMSN RQLEEAGEND VNNFFQLTVE MFDYLECELN
     LFLSVFSSLD MSRSVSVTAA GQCRLAPLIQ VILDCSHLYD YTVKLLFKLH SCLPPDTLQG
     HRDRFLEQFK KIKSLFYRSS NLQYFKRLIQ IPQLPENPPN FLRASALSEH ISPVVVIPAE
     SSSPESEHAV ETDDLVDTDV PAFQQSLETK FDDLFGTSAP TDPFNFNSQN GTRKDDKARL
     IDQLTREIQV LKDELESFRL ESDQLRRALK GRVSELEAEL AEQSHLRLQA AGESEFLKAE
     LEDLRRVRED TEKEHRSVTE IEKKAQANEQ RYTKLKEKYT ELVQSHADLL RKNAEVTRQM
     SVARVAQDEV DAVRREMQEK LKAAQEYTER QKSCRTSSTK RCQNEPLGVD ILESGSSKSE
     LMCCCPQESR EQALESQVEE ARRSCLQGAL EEAQKMVQDA LAQIDDPAHI SCTSSAGKTR
     SGSSMDAVSS LCCHRVCLGP LQITWRRDKL RPRGLELQQG ELGDLVEQEM AATSAAVESA
     AARIEDMLNK SRAVDTGVKM EVNERILASC TDLMQAIKEL VLSSKHLQRD IVESGRGAAS
     MKEFYAKNSR WTEGLISASK AVGWGATVMV DAADLVVQGK GKFEELMVCS HEIAASTAQL
     VAASKVKADK DSGNLQRLQQ ASRGVTQATA KLVASTKSGK SQIEETDTMD FSSMTLTQIK
     RQEMDAQVLV LELETRLQKE RERLGELRKK HYELAGVAEG WGEEEGKRVR QGAPTLQRRP
//