ID A0A6A1Q713_BALPH Unreviewed; 715 AA.
AC A0A6A1Q713;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 11.
DE RecName: Full=FERM, ARHGEF and pleckstrin domain-containing protein 1 {ECO:0000256|ARBA:ARBA00040395};
DE AltName: Full=FERM, RhoGEF and pleckstrin domain-containing protein 1 {ECO:0000256|ARBA:ARBA00042170};
GN ORFNames=E2I00_011126 {ECO:0000313|EMBL:KAB0402923.1};
OS Balaenoptera physalus (Fin whale) (Balaena physalus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=9770 {ECO:0000313|EMBL:KAB0402923.1, ECO:0000313|Proteomes:UP000437017};
RN [1] {ECO:0000313|EMBL:KAB0402923.1, ECO:0000313|Proteomes:UP000437017}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FinWhale-01 {ECO:0000313|EMBL:KAB0402923.1};
RX PubMed=31553763;
RA Westbury M.V., Petersen B., Lorenzen E.D.;
RT "Genomic analyses reveal an absence of contemporary introgressive admixture
RT between fin whales and blue whales, despite known hybrids.";
RL PLoS ONE 14:0-e0222004(2019).
CC -!- SUBCELLULAR LOCATION: Cell projection, dendrite
CC {ECO:0000256|ARBA:ARBA00004279}. Cell projection, filopodium
CC {ECO:0000256|ARBA:ARBA00004486}. Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Synapse, synaptosome
CC {ECO:0000256|ARBA:ARBA00034102}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAB0402923.1}.
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DR EMBL; SGJD01000915; KAB0402923.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A6A1Q713; -.
DR Proteomes; UP000437017; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR GO; GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd13193; FERM_C_FARP1-like; 1.
DR CDD; cd01220; PH1_FARP1-like; 1.
DR CDD; cd13235; PH2_FARP1-like; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR014847; FA.
DR InterPro; IPR041788; FARP1/FARP2/FRMD7_FERM_C.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR45858; FERM DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45858:SF2; FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 3.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Reference proteome {ECO:0000313|Proteomes:UP000437017};
KW Synapse {ECO:0000256|ARBA:ARBA00022599};
KW Synaptosome {ECO:0000256|ARBA:ARBA00022599}.
FT DOMAIN 1..97
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 239..430
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 459..556
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 580..678
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 195..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 715 AA; 81857 MW; 8689D1F246955D70 CRC64;
MYGIRLHPAK DREGTKINLA VANTGILVFQ GFTKINAFNW AKVRKLSFKR KRFLIKLRPD
VNSSYQDTLE FLMASRDFCK SFWKICVEHH AFFRLFEEPK PKPKPVLFSR GSSFRFSGRT
QKQVLDYVKE GGHKKVQFES FNQRSYGFNQ LFPLKMLFPV STQYGFGAIE VISSLTGSPH
LSELSINSQG GATNTILSPN LSPDAKQASP LVSPLLNDQV GPRTDDEDDG RRKRFPTDKA
YFIAKEVSTT ERTYLKDLEV ITSWFQSTVS KEDSMPETLK SLIFPNFEPL HKFHTNFLKE
IEQRLALWEG RSNAHIRGDY QRIGDVMLKN IQGMKQLAAH LWKHSEALEA LETGIRGSRR
LESLCRDFEL QKVCYLSLNT FLLRPLHRLM HYKQVLERLC KHHPPSHADF RDCRAALAEI
TEMVAQLHGT MIKMENFQKL HELKKDLIGV DNLVIPGREF IRLGSLSKLS GKGLQQRMFF
LFNDVLLYTS RGLTASNQFK VHGQLPLYGM TMEESEDEWG VPHCFTLRGQ RQSIVVAASS
RSEMEKWVED IQMAIDLAEK SSGPAPEFLA SSPPDSRLVQ NQLSGNLLRK FKNSNGWQKL
WVVFTNFCLF FYKSHQDSHP LASLPLLGYS LTIPSESEDI HKDYVFKLHF KSHVYYFRAE
SEYTFERTIL NLVFAAVNFS SERDRTPAFN AGGVSAVMPS VGCLQLVPVL KHCHG
//