ID A0A6A1QEH0_BALPH Unreviewed; 495 AA.
AC A0A6A1QEH0;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 22-FEB-2023, entry version 9.
DE RecName: Full=Gap junction protein {ECO:0000256|RuleBase:RU000630};
GN ORFNames=E2I00_002350 {ECO:0000313|EMBL:KAB0404949.1};
OS Balaenoptera physalus (Fin whale) (Balaena physalus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=9770 {ECO:0000313|EMBL:KAB0404949.1, ECO:0000313|Proteomes:UP000437017};
RN [1] {ECO:0000313|EMBL:KAB0404949.1, ECO:0000313|Proteomes:UP000437017}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FinWhale-01 {ECO:0000313|EMBL:KAB0404949.1};
RX PubMed=31553763;
RA Westbury M.V., Petersen B., Lorenzen E.D.;
RT "Genomic analyses reveal an absence of contemporary introgressive admixture
RT between fin whales and blue whales, despite known hybrids.";
RL PLoS ONE 14:0-e0222004(2019).
CC -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC pairs of transmembrane channels, the connexons, through which materials
CC of low MW diffuse from one cell to a neighboring cell.
CC {ECO:0000256|RuleBase:RU000630}.
CC -!- SUBUNIT: A connexon is composed of a hexamer of connexins.
CC {ECO:0000256|RuleBase:RU000630}.
CC -!- SUBCELLULAR LOCATION: Cell junction, gap junction
CC {ECO:0000256|ARBA:ARBA00004610}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU000630}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU000630}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the connexin family.
CC {ECO:0000256|RuleBase:RU000630}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAB0404949.1}.
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DR EMBL; SGJD01000503; KAB0404949.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A6A1QEH0; -.
DR Proteomes; UP000437017; Unassembled WGS sequence.
DR GO; GO:0005922; C:connexin complex; IEA:InterPro.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR Gene3D; 1.20.1440.80; Gap junction channel protein cysteine-rich domain; 1.
DR InterPro; IPR000500; Connexin.
DR InterPro; IPR019570; Connexin_CCC.
DR InterPro; IPR017990; Connexin_CS.
DR InterPro; IPR013092; Connexin_N.
DR InterPro; IPR038359; Connexin_N_sf.
DR PANTHER; PTHR11984; CONNEXIN; 1.
DR PANTHER; PTHR11984:SF60; GAP JUNCTION ALPHA-9 PROTEIN; 1.
DR Pfam; PF00029; Connexin; 1.
DR PRINTS; PR00206; CONNEXIN.
DR SMART; SM00037; CNX; 1.
DR SMART; SM01089; Connexin_CCC; 1.
DR PROSITE; PS00407; CONNEXINS_1; 1.
DR PROSITE; PS00408; CONNEXINS_2; 1.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Gap junction {ECO:0000256|ARBA:ARBA00022868,
KW ECO:0000256|RuleBase:RU000630};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000437017};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000630};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..495
FT /note="Gap junction protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025515409"
FT TRANSMEM 59..81
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 191..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 24..57
FT /note="Connexin N-terminal"
FT /evidence="ECO:0000259|SMART:SM00037"
FT DOMAIN 148..214
FT /note="Gap junction protein cysteine-rich"
FT /evidence="ECO:0000259|SMART:SM01089"
FT REGION 278..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 327..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 81..119
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 332..365
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 495 AA; 56069 MW; 4235F6A454722EF3 CRC64;
MIGKMWLTVL FIFRMLVLGV AAEDVWNDEQ SDFICNTEQP GCRNVCYDQA FPISLIRYWV
LQVIFVSSPS LVYMGHALYQ LRVLEKERQM KKAQLRGELE EAELEMPGDR RRLEQELRQL
EQRKLNKAPL RGTLLCTYVI HIFTRSVVEV GFMIGQYLLY GFNLDPLFKC HGHPCPNIID
CFVSRPTEKT IFLLFMQSIA TVSLFLNVLE IFHLGFKKIK RGLWGQYKLK DEHNEFCTTK
SRQNLAKYQN TSANSLKRFS FAPDYSLLVE KQTHTAAYPG LNPPAFQTDP DNHSGNDDKG
ILDEQETLLS EMCMLSATCG HLQNINSSNK EDTHKISGKE VNGNQLRGKR ETDGKDSKRN
HYSKGHCSIP GDAIDLNNHT GQSPQTAFSL PANYTWKPKW LRAAWGPSAE NENQALPPKG
NLKGQLREST IRTLPPSQGD FHPLDIPDTP DSLGGLSFES ELVRTCSNPT ACPPNHLVSL
TNNLIGRRAP TDLQI
//
