ID A0A6A3BCU7_HIBSY Unreviewed; 666 AA.
AC A0A6A3BCU7;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 10.
DE RecName: Full=Nicastrin {ECO:0000256|ARBA:ARBA00015303};
GN ORFNames=F3Y22_tig00110204pilonHSYRG00127
GN {ECO:0000313|EMBL:KAE8713861.1};
OS Hibiscus syriacus (Rose of Sharon).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Hibiscus.
OX NCBI_TaxID=106335 {ECO:0000313|EMBL:KAE8713861.1, ECO:0000313|Proteomes:UP000436088};
RN [1] {ECO:0000313|EMBL:KAE8713861.1, ECO:0000313|Proteomes:UP000436088}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Baekdansim {ECO:0000313|Proteomes:UP000436088};
RC TISSUE=Leaf {ECO:0000313|EMBL:KAE8713861.1};
RA Kim Y.-M.;
RT "Draft genome information of white flower Hibiscus syriacus.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the nicastrin family.
CC {ECO:0000256|ARBA:ARBA00007717}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAE8713861.1}.
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DR EMBL; VEPZ02000875; KAE8713861.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A6A3BCU7; -.
DR Proteomes; UP000436088; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0016485; P:protein processing; IEA:InterPro.
DR CDD; cd03881; M28_Nicastrin; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR041084; Ncstrn_small.
DR InterPro; IPR008710; Nicastrin.
DR PANTHER; PTHR21092; NICASTRIN; 1.
DR PANTHER; PTHR21092:SF0; NICASTRIN; 1.
DR Pfam; PF18266; Ncstrn_small; 1.
DR Pfam; PF05450; Nicastrin; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Reference proteome {ECO:0000313|Proteomes:UP000436088};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..666
FT /note="Nicastrin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025383986"
FT TRANSMEM 636..659
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 45..202
FT /note="Nicastrin small lobe"
FT /evidence="ECO:0000259|Pfam:PF18266"
SQ SEQUENCE 666 AA; 71966 MW; 41F921238ED88D4A CRC64;
MDIKNFFLIL LFSIWFRSSL SGQTNSMESV PDLQKSMYMA VDGYPCVRLV NLSGEIGCSN
PGRDKVVSPI IKYKNNKGLA QPSAILLSMD DVQGFFSRVS NDSSFARNVG GVLVESGVAI
QHKQKGFSPA QKFPQAAFAP YLNTTYEWNP IGSGIMWKSY NFPVFLLSES STSALQEIAM
KNEKAEKAYT KNVAEFDVVM QTTKVGTHDS ESCLTEETCL PLGGYSVWSA VPPINNSSSK
QSKPIILTVA SMDAASFFRD KSLGADSPIS GVISLLAAVD ALSHVDGLDD LKKQLVFLVF
TGEAWGYLGS RRFLLELDKQ SDAVHGLDSS LIQLVMEIGS TGKGLSQGNK TFFAHTKVSS
GANEALDALK LAQESLKSEG VTVSNASSSN PGIPPSSLMA FLRKNSSTSG IVLEDFDTVF
ANKFFHSHLD DSANINSSSI VAAASLVART LYLLASDKKD LTNSALSAIN VNASLVEELI
SCMLKCNPGL SCELVSSYIK STNTCPNHYV GVVLGEPSST PYPDQVDDVS RFVWNFLADR
TSTPKGNTSV CSEDCAKNGG LCIRAELDGK GVCVVSTTRY VPAYSTRLKF DSGTWKVLPP
NSSDPMGMLD PVWTESNWNT IGLRVYTIQE AAYDRLVLLG GITVTVFAYL AIVLTRAYIT
KALKQD
//
