ID A0A6A4CRE0_9STRA Unreviewed; 1061 AA.
AC A0A6A4CRE0;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=Reverse transcriptase {ECO:0008006|Google:ProtNLM};
GN ORFNames=PR003_g24021 {ECO:0000313|EMBL:KAE9295409.1};
OS Phytophthora rubi.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=129364 {ECO:0000313|EMBL:KAE9295409.1, ECO:0000313|Proteomes:UP000434957};
RN [1] {ECO:0000313|EMBL:KAE9295409.1, ECO:0000313|Proteomes:UP000434957}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SCRP333 {ECO:0000313|EMBL:KAE9295409.1,
RC ECO:0000313|Proteomes:UP000434957};
RA Adams T.M., Armitage A.D., Sobczyk M.K., Bates H.J., Dunwell J.M.,
RA Nellist C.F., Harrison R.J.;
RT "Genomic investigation of the strawberry pathogen Phytophthora fragariae
RT indicates pathogenicity is determined by transcriptional variation in three
RT key races.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAE9295409.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; QXFT01002624; KAE9295409.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A6A4CRE0; -.
DR Proteomes; UP000434957; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 1.10.340.70; -; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR041588; Integrase_H2C2.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041373; RT_RNaseH.
DR PANTHER; PTHR37984:SF7; INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR37984; PROTEIN CBG26694; 1.
DR Pfam; PF17921; Integrase_H2C2; 1.
DR Pfam; PF17917; RT_RNaseH; 1.
DR Pfam; PF00078; RVT_1; 1.
DR Pfam; PF13456; RVT_3; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 2.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000434957}.
FT DOMAIN 270..366
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|Pfam:PF00078"
FT DOMAIN 552..654
FT /note="Reverse transcriptase RNase H-like"
FT /evidence="ECO:0000259|Pfam:PF17917"
FT DOMAIN 719..839
FT /note="RNase H type-1"
FT /evidence="ECO:0000259|Pfam:PF13456"
FT DOMAIN 1013..1061
FT /note="Integrase zinc-binding"
FT /evidence="ECO:0000259|Pfam:PF17921"
FT REGION 74..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..93
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1061 AA; 119304 MW; 4F96411D8297E3E5 CRC64;
MLRPRRGATA ARIVQLQDQP KQVHSTNVER PANVVCNVAT QTTELADVGT QTDVAQEFTE
RTVLKVSVPE SIEANSSKAE LDTEPSCSDS EVQEGQDQET EEMDLPSCAW PSTSIRRLEE
EYARYMRISQ EYLDLEPAIY LQEGSEVLSQ LRDELAMLPE LKDLSPECDI SKADVGDPDE
TTAAEEKKLR SILTYHRKIL LGDGNAAPAP ARGVVWDLDV GDAKPVAQRP RSIAPHIMLK
VNELLKKLLE TELIEFSVSA WASPLVIVLK KNGVDIRVCI DYRVVNGFIQ LSTYPLPLID
DLLIGFESAM WFMSLDVASG FSAIRMAERA KLISAFVCPF GHFQWVRMPF GLKNAPLVYQ
AVINNCLWGF VRLPAEEEKL VDQDVLGFLG LDPFERDESE REKAERNVPI LTDKITAFKR
DIPAPSQMGP IIGRSSLRYW NISVSLPKSE FGKLSILYLS HEISVEGLRA TPKIAKGVQD
LPFPNTLKGV QSFLGSLNYY HKLIEDFPVV AAVLYELTDE QVRAGRDLSK AKEAFEILKR
KIVSTSLLRH PDRTKSFVII PHANQWAAGA VLGQEYEGVI HSVRFTGRVL NDAELRYHVA
EKEVVAVMGV LDVFQTLVQN CLVKVFTRHS VLSWLLKSKT DDGRCVRWGV ILSHWNLEVH
KVQRDEGGLP VILGAGITPR EHLDEVAESL IPAKGRVKAP PVISMEMLEA DFAGYVLSFD
GAAKTSTRQG SCGCIIWELP GWNILAAHGF ILEDVTVNDA EYYGLLKGLT LASERDIQDL
VVVGHSCIVI QQVQGLINCN QPNLQRRLSE VGMLKEKFTS MRLVHIKREY NQAADYLTSK
TLALGTSWQT EGPEELKHLV QVSKIHEKLM QPLVIMDENA QDVSPQEDLP VETPNGICPG
PESAPLSTAA RVMVAVTRNR IQEQPDQREP MGPLEYQAER WRRIKAHQEC DDQLMEIKKF
LKEDLGSFSR GQIRRISKQA ELYALDVRDV LYRLGRSTKD RPRDMSDELR LVVPESLRPD
LLHYAHENCQ DGHQGVTRTH EKLRSEFYWP GMYADVETFV K
//
