ID A0A6A4FDZ4_9STRA Unreviewed; 1023 AA.
AC A0A6A4FDZ4;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE RecName: Full=Protein HIRA {ECO:0000256|RuleBase:RU364014};
GN ORFNames=PR003_g10344 {ECO:0000313|EMBL:KAE9340705.1};
OS Phytophthora rubi.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=129364 {ECO:0000313|EMBL:KAE9340705.1, ECO:0000313|Proteomes:UP000434957};
RN [1] {ECO:0000313|EMBL:KAE9340705.1, ECO:0000313|Proteomes:UP000434957}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SCRP333 {ECO:0000313|EMBL:KAE9340705.1,
RC ECO:0000313|Proteomes:UP000434957};
RA Adams T.M., Armitage A.D., Sobczyk M.K., Bates H.J., Dunwell J.M.,
RA Nellist C.F., Harrison R.J.;
RT "Genomic investigation of the strawberry pathogen Phytophthora fragariae
RT indicates pathogenicity is determined by transcriptional variation in three
RT key races.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for replication-independent chromatin assembly and
CC for the periodic repression of histone gene transcription during the
CC cell cycle. {ECO:0000256|RuleBase:RU364014}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU364014}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family.
CC {ECO:0000256|ARBA:ARBA00007306, ECO:0000256|RuleBase:RU364014}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAE9340705.1}.
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DR EMBL; QXFT01000562; KAE9340705.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A6A4FDZ4; -.
DR Proteomes; UP000434957; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR031120; HIR1-like.
DR InterPro; IPR011494; HIRA-like_C.
DR InterPro; IPR011044; Quino_amine_DH_bsu.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13831; MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS; 1.
DR PANTHER; PTHR13831:SF0; PROTEIN HIRA; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR SUPFAM; SSF50969; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853,
KW ECO:0000256|RuleBase:RU364014}; Nucleus {ECO:0000256|RuleBase:RU364014};
KW Reference proteome {ECO:0000313|Proteomes:UP000434957};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364014};
KW Repressor {ECO:0000256|RuleBase:RU364014};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364014};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364014};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 14..48
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 64..105
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 124..165
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 173..206
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 724..943
FT /note="Protein HIRA-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07569"
FT REGION 397..456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 506..582
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 397..429
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 506..532
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 554..578
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1023 AA; 110365 MW; 394E1F041EB8D72D CRC64;
MLLEKPEDVK HENSSGTVCA IYGVDAHPTL QLFATAGGDN SVKIWSLQPP AEGGIATFEL
LATLANHQQA VNCVRWAGHG RYLASGSDDQ LVLLYELQAG APAPVPFGSN ASPNKQNWVR
CSTLERHTMD VADVAWSPDD RMLATCSIDN TILIWDVGVG AMSEVMTQPL QTLTGHNGWV
KGVAWDPVGK YLSSAGEDKT VRMWKVADWQ ESDVVTEPFE GCASTSHFRR LAWSPDGSVL
CATHAFSSKK NIAALLNRGS WTNDLKFVGH QGVVTSARFN PKLLVTKADP DKEFACCAVG
GEDATVSIWL AHLARPLAVV KDCFDSSVTD LTWSSAQSLL LACSLDGSIC CFQFGEDEIG
TPIPDAQQSK LLQAKYGSRA GITLASTLVE NPIQLQLEEK STTSPRLAAS RKSDTSVTPT
VTPTTNTLIP KKKKKLDTQT STPQSRAPSG ANKNDKKRIA PVLLQGEVQP SPNNNPASSQ
NNIRNILGPT IVSPKASDVT LLDSRMTSTN GKEVSIVPET NNSATLKSSS APSHSDKTKE
KSALAVPNDA PSKSSKPEAK KNGVDGPSLK RKRENERTAT QATAVVAKSK EVIARAPKLL
NESSAGVANG GQLLPEFPFR LQFSVEIDTN TQSNASSKAS NGRISSGLVS SKVVVEVTVH
NLKNPQPEEI IELGPVYSTI QCSAGNEVKW IDRIPGRVVC AVGNTSYYAV GVHNGDLLVL
NSSGRRLFPC IALGSSISVM ECSMNESPYL LVILATGDLK IWDLAARKLL LASSIEAITN
VTPEDHRKLT LLRCQVTTKG MPLITFAESN SEIKGSSSLL SYTYDTAMSS WMRVADDSFV
FSDFASALST DAVSVKSVPI GPLRRLQNAS GYGRTQRGIA SAMLSGMSDP LMQRNVTRSH
LEHQVVSAII LKSSAEYRYW IQAYAKFLTH DEDVTRLDNL CAEMMGPFHA PSTREGTAAN
QDEGSAWDPM ALDLVKRDVL KSHILPTIAA NRALQRVVTK YQLMLSEIEA REKDEDDDGD
DEA
//
