ID A0A6A4FHZ1_9STRA Unreviewed; 330 AA.
AC A0A6A4FHZ1;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 24-JAN-2024, entry version 9.
DE RecName: Full=tRNA(adenine(34)) deaminase {ECO:0000256|ARBA:ARBA00012740};
DE EC=3.5.4.33 {ECO:0000256|ARBA:ARBA00012740};
GN ORFNames=PR001_g5657 {ECO:0000313|EMBL:KAE9043763.1}, PR002_g6115
GN {ECO:0000313|EMBL:KAE9038284.1}, PR003_g5984
GN {ECO:0000313|EMBL:KAE9349255.1};
OS Phytophthora rubi.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=129364 {ECO:0000313|EMBL:KAE9349255.1, ECO:0000313|Proteomes:UP000434957};
RN [1] {ECO:0000313|EMBL:KAE9349255.1, ECO:0000313|Proteomes:UP000434957}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SCRP249 {ECO:0000313|EMBL:KAE9043763.1,
RC ECO:0000313|Proteomes:UP000429607}, SCRP324
RC {ECO:0000313|EMBL:KAE9038284.1, ECO:0000313|Proteomes:UP000435112},
RC and SCRP333 {ECO:0000313|EMBL:KAE9349255.1,
RC ECO:0000313|Proteomes:UP000434957};
RA Adams T.M., Armitage A.D., Sobczyk M.K., Bates H.J., Dunwell J.M.,
RA Nellist C.F., Harrison R.J.;
RT "Genomic investigation of the strawberry pathogen Phytophthora fragariae
RT indicates pathogenicity is determined by transcriptional variation in three
RT key races.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA +
CC NH4(+); Xref=Rhea:RHEA:43168, Rhea:RHEA-COMP:10373, Rhea:RHEA-
CC COMP:10374, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:74411, ChEBI:CHEBI:82852; EC=3.5.4.33;
CC Evidence={ECO:0000256|ARBA:ARBA00001103};
CC -!- SIMILARITY: Belongs to the cytidine and deoxycytidylate deaminase
CC family. ADAT3 subfamily. {ECO:0000256|ARBA:ARBA00038160}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAE9349255.1}.
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DR EMBL; QXFU01000270; KAE9038284.1; -; Genomic_DNA.
DR EMBL; QXFV01000254; KAE9043763.1; -; Genomic_DNA.
DR EMBL; QXFT01000258; KAE9349255.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A6A4FHZ1; -.
DR Proteomes; UP000429607; Unassembled WGS sequence.
DR Proteomes; UP000434957; Unassembled WGS sequence.
DR Proteomes; UP000435112; Unassembled WGS sequence.
DR GO; GO:0008251; F:tRNA-specific adenosine deaminase activity; IEA:InterPro.
DR GO; GO:0002100; P:tRNA wobble adenosine to inosine editing; IEA:InterPro.
DR Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR InterPro; IPR002125; CMP_dCMP_dom.
DR InterPro; IPR016193; Cytidine_deaminase-like.
DR InterPro; IPR028883; tRNA_aden_deaminase.
DR PANTHER; PTHR11079; CYTOSINE DEAMINASE FAMILY MEMBER; 1.
DR PANTHER; PTHR11079:SF156; INACTIVE TRNA-SPECIFIC ADENOSINE DEAMINASE-LIKE PROTEIN 3-RELATED; 1.
DR Pfam; PF14437; MafB19-deam; 1.
DR SUPFAM; SSF53927; Cytidine deaminase-like; 1.
DR PROSITE; PS51747; CYT_DCMP_DEAMINASES_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000434957};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 146..317
FT /note="CMP/dCMP-type deaminase"
FT /evidence="ECO:0000259|PROSITE:PS51747"
FT REGION 228..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..249
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 330 AA; 37130 MW; 7C40F8ADB62C6843 CRC64;
MELVEVVPPE DFDAEALEAQ QRFVALEFPA RFGSKVMKHL SSSFQPLPEL GFAHLKRLKK
HAESPKTLVA LVCPLTSNAH DVAEPSNELK QLETMFDARL TTAEALKLAP RTRELFEKHT
KHWPLIFHAS VEEAAALPPI EDDEKRKMLK HLKEAVGVGG RTKDERKQTL SCAWGCVVVD
PEGDEIVATS EVGEELKPKY KFKALYHPVM VAVDAVAERD RRREAEVEEK AAKKQKTAEG
EDAATAERQE SRETGSYLCT GYDVYLDREP CGMCAMALVH SRARRVVFDR ANPEDGVLLS
SFKLHTIKSL NHHYRVFQLA ISQDEAKRTC
//
