ID A0A6A4PLS2_LUPAL Unreviewed; 258 AA.
AC A0A6A4PLS2;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=PHD finger protein ALFIN-LIKE {ECO:0000256|RuleBase:RU369089};
GN ORFNames=Lalb_Chr12g0200001 {ECO:0000313|EMBL:KAE9602478.1};
OS Lupinus albus (White lupine) (Lupinus termis).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC genistoids sensu lato; core genistoids; Genisteae; Lupinus.
OX NCBI_TaxID=3870 {ECO:0000313|EMBL:KAE9602478.1, ECO:0000313|Proteomes:UP000447434};
RN [1] {ECO:0000313|Proteomes:UP000447434}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Amiga {ECO:0000313|Proteomes:UP000447434};
RX DOI=10.1038/s41467-019-14197-9;
RA Hufnagel B., Marques A., Soriano A., Marques L., Divol F., Doumas P.,
RA Sallet E., Mancinotti D., Carrere S., Marande W., Arribat S., Keller J.,
RA Huneau C., Blein T., Aime D., Laguerre M., Taylor J., Schubert V.,
RA Nelson M., Geu-Flores F., Crespi M., Gallardo-Guerrero K., Delaux P.-M.,
RA Salse J., Berges H., Guyot R., Gouzy J., Peret B.;
RT "Genome sequence of the cluster root forming white lupin.";
RL Nat. Commun. 11:492-492(2020).
CC -!- FUNCTION: Histone-binding component that specifically recognizes H3
CC tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription
CC start sites of virtually all active genes.
CC {ECO:0000256|RuleBase:RU369089}.
CC -!- SUBUNIT: Interacts with H3K4me3 and to a lesser extent with H3K4me2.
CC {ECO:0000256|RuleBase:RU369089}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU369089}.
CC -!- DOMAIN: The PHD-type zinc finger mediates the binding to H3K4me3.
CC {ECO:0000256|RuleBase:RU369089}.
CC -!- SIMILARITY: Belongs to the Alfin family.
CC {ECO:0000256|ARBA:ARBA00010445, ECO:0000256|RuleBase:RU369089}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAE9602478.1}.
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DR EMBL; WOCE01000012; KAE9602478.1; -; Genomic_DNA.
DR Proteomes; UP000447434; Chromosome 12.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0042393; F:histone binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR CDD; cd15613; PHD_AL_plant; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR045104; Alfin.
DR InterPro; IPR021998; Alfin_N.
DR InterPro; IPR044104; PHD_AL_plant.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12321; CPG BINDING PROTEIN; 1.
DR PANTHER; PTHR12321:SF98; PHD FINGER PROTEIN ALFIN-LIKE 4; 1.
DR Pfam; PF12165; Alfin; 1.
DR Pfam; PF00628; PHD; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|RuleBase:RU369089};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU369089}; Nucleus {ECO:0000256|RuleBase:RU369089};
KW Reference proteome {ECO:0000313|Proteomes:UP000447434};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU369089};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU369089};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU369089};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU369089}.
SQ SEQUENCE 258 AA; 29186 MW; D6817DCEC1F557F4 CRC64;
MDGGTQYNPR TVEEVFKDFK GRRVAIIKAL TTDVHQFFQQ CDPEKDNLCL YGLPTEQWEV
NLPAEEVPPE LPEPALGINF ARDGMQEKDW LSLVAVHSDA WLLAVAFYFG ARFGFDRADR
KRLFTMVNDL PTIFEVVTGT AKKQTMEKSS ISNITGNKSK SGSKGRGSES GKYSKLAEEE
EEEVLVEDEE EVIVEEDEEH GETLCGACGE NYATDEFWIC CDICEKWFHG KCVKITPARA
DHIKHYKCPS CSNKRARP
//
