ID A0A6A4VBK4_AMPAM Unreviewed; 342 AA.
AC A0A6A4VBK4;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 8.
DE SubName: Full=Cathepsin L-like proteinase {ECO:0000313|EMBL:KAF0291175.1};
GN Name=Cat-1_0 {ECO:0000313|EMBL:KAF0291175.1};
GN ORFNames=FJT64_010671 {ECO:0000313|EMBL:KAF0291175.1};
OS Amphibalanus amphitrite (Striped barnacle) (Balanus amphitrite).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC Cirripedia; Thoracica; Thoracicalcarea; Balanomorpha; Balanoidea;
OC Balanidae; Amphibalaninae; Amphibalanus.
OX NCBI_TaxID=1232801 {ECO:0000313|EMBL:KAF0291175.1, ECO:0000313|Proteomes:UP000440578};
RN [1] {ECO:0000313|EMBL:KAF0291175.1, ECO:0000313|Proteomes:UP000440578}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SNU_AA5 {ECO:0000313|EMBL:KAF0291175.1};
RC TISSUE=Soma without cirri and trophi {ECO:0000313|EMBL:KAF0291175.1};
RA Kim W.;
RT "Draft genome assembly of a fouling barnacle, Amphibalanus amphitrite
RT (Darwin, 1854): The first reference genome for Thecostraca.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAF0291175.1}.
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DR EMBL; VIIS01001902; KAF0291175.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A6A4VBK4; -.
DR Proteomes; UP000440578; Unassembled WGS sequence.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 1.10.287.2250; -; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411:SF741; CATHEPSIN K; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000440578};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..342
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025627793"
FT DOMAIN 24..83
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 103..298
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
FT REGION 315..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 342 AA; 37444 MW; 063DB0E8AE403CEF CRC64;
MKPLSPVLLA AVLSVAAANE NDEWLAFKQR FGRVYEAEEE VLRRWVFVEN LERIRLHNAE
HDAGRSTFRL GVNQFADLTN EEFRQKLLTE PVRGTPTSVN VTAPDSFDWR TEGVPIRIQD
QGQLGASWTI ATLSSVEAGV FLSSGQTVSL SDQNLLDCVS WPSTGRRARV QSVITAWPSE
ADYPTTGGVG ACQPVAPSAG LDEVHQVLEG DEVALAEGLL QNPVPVMFDV EFSFQLYSSG
IYSDPGCSPD QLNHALLLVG YGSSGQDFWT LANSWGTSWG EGGYVRVPEG RQHVWSGHDG
GLSNRRPPAL SWSAANQRTT TSQDTALHTS QKSETLHRCT PF
//
