ID A0A6A5BHT9_NAEFO Unreviewed; 463 AA.
AC A0A6A5BHT9;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 28-JUN-2023, entry version 11.
DE RecName: Full=PCI domain-containing protein {ECO:0000259|PROSITE:PS50250};
GN ORFNames=FDP41_008312 {ECO:0000313|EMBL:KAF0973608.1};
OS Naegleria fowleri (Brain eating amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5763 {ECO:0000313|EMBL:KAF0973608.1, ECO:0000313|Proteomes:UP000444721};
RN [1] {ECO:0000313|EMBL:KAF0973608.1, ECO:0000313|Proteomes:UP000444721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 30894 {ECO:0000313|EMBL:KAF0973608.1,
RC ECO:0000313|Proteomes:UP000444721};
RX PubMed=31690847;
RA Liechti N., Schurch N., Bruggmann R., Wittwer M.;
RT "Nanopore sequencing improves the draft genome of the human pathogenic
RT amoeba Naegleria fowleri.";
RL Sci. Rep. 9:0-16040(2019).
CC -!- SIMILARITY: Belongs to the proteasome subunit p55 family.
CC {ECO:0000256|ARBA:ARBA00006397}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAF0973608.1}.
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DR EMBL; VFQX01000060; KAF0973608.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A6A5BHT9; -.
DR VEuPathDB; AmoebaDB:FDP41_008312; -.
DR VEuPathDB; AmoebaDB:NF0002210; -.
DR VEuPathDB; AmoebaDB:NfTy_090580; -.
DR OrthoDB; 158659at2759; -.
DR Proteomes; UP000444721; Unassembled WGS sequence.
DR GO; GO:0000502; C:proteasome complex; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000717; PCI_dom.
DR InterPro; IPR040134; PSMD12/CSN4.
DR InterPro; IPR040896; RPN5_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10855:SF1; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12; 1.
DR PANTHER; PTHR10855; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4; 1.
DR Pfam; PF01399; PCI; 1.
DR Pfam; PF18098; RPN5_C; 1.
DR SMART; SM00088; PINT; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Proteasome {ECO:0000256|ARBA:ARBA00022942};
KW Reference proteome {ECO:0000313|Proteomes:UP000444721}.
FT DOMAIN 251..424
FT /note="PCI"
FT /evidence="ECO:0000259|PROSITE:PS50250"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..30
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 463 AA; 54089 MW; 1DE6B957EA1C3061 CRC64;
MPLPTFDPED PSSNEVDQER KKKHMDVDYS EQTDQTISSA NQAIEKGGIS ALKQALEPVL
ALEKTVRLAE DYENLSKVLV NIVAMCAKVQ AWDELNDQLT LLAKKRSQSR GAIQKMIQEA
MKYIDLTPSK ERKIELINTI RKITEGKIFV ELEGARVTRM LAKIREEEGN ISEAASLLQD
VQVETINSMA IREKIDFILE SIRLCLEKQD YVRAVIVSKK ITKKSISEED HQDLKIRYYE
LMIRFYSQKK HYLDIFRSYQ QIFTTPIIQA NDDEWMRILQ HMVLYIVLAE YGNEQHDLMH
RTFEEKKLEE PKLQPFRMLL KQFVSRGVIN WPQFEAQFGA IIKNHPIFTK SPETYADLRS
RVVEKNIRTI AQFYSRIETK RISELLYLNE DEVEGFISRM VTNKTINAKM DRLQGVIVFK
QVQNGEDNDV LNSWAHDIVK LLQLVEKSNH LINKEYMIQN ARQ
//
