ID A0A6A5BMK9_NAEFO Unreviewed; 462 AA.
AC A0A6A5BMK9;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 13-SEP-2023, entry version 9.
DE RecName: Full=Serine incorporator {ECO:0008006|Google:ProtNLM};
GN ORFNames=FDP41_006279 {ECO:0000313|EMBL:KAF0974805.1};
OS Naegleria fowleri (Brain eating amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5763 {ECO:0000313|EMBL:KAF0974805.1, ECO:0000313|Proteomes:UP000444721};
RN [1] {ECO:0000313|EMBL:KAF0974805.1, ECO:0000313|Proteomes:UP000444721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 30894 {ECO:0000313|EMBL:KAF0974805.1,
RC ECO:0000313|Proteomes:UP000444721};
RX PubMed=31690847;
RA Liechti N., Schurch N., Bruggmann R., Wittwer M.;
RT "Nanopore sequencing improves the draft genome of the human pathogenic
RT amoeba Naegleria fowleri.";
RL Sci. Rep. 9:0-16040(2019).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TDE1 family.
CC {ECO:0000256|ARBA:ARBA00006665}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAF0974805.1}.
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DR EMBL; VFQX01000051; KAF0974805.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A6A5BMK9; -.
DR VEuPathDB; AmoebaDB:FDP41_006279; -.
DR VEuPathDB; AmoebaDB:NF0089990; -.
DR VEuPathDB; AmoebaDB:NfTy_076960; -.
DR OrthoDB; 53161at2759; -.
DR Proteomes; UP000444721; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR005016; TDE1/TMS.
DR PANTHER; PTHR10383; SERINE INCORPORATOR; 1.
DR PANTHER; PTHR10383:SF9; TMS1, ISOFORM F; 1.
DR Pfam; PF03348; Serinc; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000444721};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 60..80
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 114..139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 151..169
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 175..197
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 218..244
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 256..275
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 282..299
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 319..339
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 390..411
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 431..449
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 359..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 462 AA; 53063 MW; 0BB363EB13F59537 CRC64;
MFHWNEFEPQ KKALRTISLF SQAHRRDTCN KIMPSYIDID TGEESGWRSR LRAIKPRRLT
LTRTVYASFL VIAFLVALFL REGLFGFFDN VPFGQDVKNW FLSSVLSRVQ GKYAVYRVCF
GCFCYYLLFA FLASRLFCVG DRVRLYIQNK WFIVKLPLFT LFMIIPFFIP DVFLYGFAWF
SLVMACIFII VQLIILIDFS FSSAEWFRAK GDDSSYGFWD YLMLAIAFLF YVLAVAFVIV
EFVFFGAGAD CHLNRFFISF TVVAAVISTI IAMVLKRGIY PTGLIFLYTA FLCWSALTSD
PSKACNSLGD FSQQGGTNST ASSIITIVIS VLITVFAIVR SAISTGLSFS SFFTMSRHPD
DNKSTNNDDD EEVDENDQDD DAKRAECSEL FYAHVVFMFS SCYMSCVLAN WDILSMQDEQ
WYVDHSLAAM WVKIATQWVC MGIFGWALIA PKVLKRYRDF DY
//
