ID A0A6A5BZE8_NAEFO Unreviewed; 775 AA.
AC A0A6A5BZE8;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 9.
DE RecName: Full=Protein kinase domain-containing protein {ECO:0000259|PROSITE:PS50011};
GN ORFNames=FDP41_001085 {ECO:0000313|EMBL:KAF0979932.1};
OS Naegleria fowleri (Brain eating amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5763 {ECO:0000313|EMBL:KAF0979932.1, ECO:0000313|Proteomes:UP000444721};
RN [1] {ECO:0000313|EMBL:KAF0979932.1, ECO:0000313|Proteomes:UP000444721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 30894 {ECO:0000313|EMBL:KAF0979932.1,
RC ECO:0000313|Proteomes:UP000444721};
RX PubMed=31690847;
RA Liechti N., Schurch N., Bruggmann R., Wittwer M.;
RT "Nanopore sequencing improves the draft genome of the human pathogenic
RT amoeba Naegleria fowleri.";
RL Sci. Rep. 9:0-16040(2019).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAF0979932.1}.
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DR EMBL; VFQX01000022; KAF0979932.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A6A5BZE8; -.
DR VEuPathDB; AmoebaDB:FDP41_001085; -.
DR VEuPathDB; AmoebaDB:NF0012750; -.
DR VEuPathDB; AmoebaDB:NfTy_049500; -.
DR OrthoDB; 5482398at2759; -.
DR Proteomes; UP000444721; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR CDD; cd13999; STKc_MAP3K-like; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR024370; PBP_domain.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR23257; SERINE-THREONINE PROTEIN KINASE; 1.
DR Pfam; PF12849; PBP_like_2; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000256|ARBA:ARBA00022527};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000444721};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022527};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 419..448
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 502..764
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 529
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 775 AA; 87517 MW; 62DB0551A4AB0D0C CRC64;
MEYNEQLDSM SAFQKLMTTD LVMSDVNIPQ VFSNGVYENS QPLPINGTSC VQNMFGVLVF
CVNSQFTTTD SNAISQMNLS LDTLVKIYDG TVRYWNDTRI VNDNPSLASQ LPFTEIKLLT
RSGSSGTSFN VLNYLATMNS EFEKKYQIYS KPTLNLRQVL NLPNLVTSVD ISTNTEMIRN
VNSMEGSIGY TSLNVYNNIP SAQKSRTVLV NIILNGVTVS PNLENVKSTI SKYDSKTLTS
SSIFSQSLKI AQSFTTSSTL YYPFVTFTFW CVKTSYSNAE EGTSILQFML NSYRAMDSAF
KVNLSPDASL SFMSENMNDS ELVTVKSSTN SISTTRSTTS SLMTTSITTS SLITTLRERL
VHFEMKRTED VFRSGTSALM TSLSTFNFKT LSDRMMCDNK KCSSLLQNNS LPTTSPFELF
LIIAIPIMGV LILSILAIVI GIISYCIVKR RRRSKTPSQL NQQLLDDMDD DQQQQDSAST
YTYTPKLFEY DQLKSTIKAD ELTLDEQIGS GSFSEVYKGR WLGAIVAVKR FMINHHVESE
EVIQDFIKES KLMSKLRHPN VVQFLGVCVQ MPHLYMVTEF CERGNLQHIL KDKKIKLSLR
KTISLALDAA RGMLYLHSNN PPIVHRDFKS ANLLVDKNWS VKVADFGMSR ILDSQQQMTV
CGTAETCAPE VLKRSMYTEK ADVYSYGIVL WELFTRGQLY PGLGFYELSS RVVNEGLRPD
MTGPRFTEGH IPKEIVSLMT QCWDEDPNVR PDFGRIVEIL EEELEMELER SRKTK
//
