ID A0A6A5D7B1_SCHHA Unreviewed; 768 AA.
AC A0A6A5D7B1;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 24-JAN-2024, entry version 10.
DE RecName: Full=EF-hand domain-containing family member C2 {ECO:0000256|ARBA:ARBA00039880};
GN Name=EFHC2_1 {ECO:0000313|EMBL:KAH9593713.1};
GN ORFNames=MS3_00009074 {ECO:0000313|EMBL:KAH9593713.1}, MS3_0018916
GN {ECO:0000313|EMBL:KAF1324124.1};
OS Schistosoma haematobium (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6185 {ECO:0000313|EMBL:KAF1324124.1};
RN [1] {ECO:0000313|EMBL:KAF1324124.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22246508; DOI=10.1038/ng.1065;
RA Young N.D., Jex A.R., Li B., Liu S., Yang L., Xiong Z., Li Y.,
RA Cantacessi C., Hall R.S., Xu X., Chen F., Wu X., Zerlotini A., Oliveira G.,
RA Hofmann A., Zhang G., Fang X., Kang Y., Campbell B.E., Loukas A.,
RA Ranganathan S., Rollinson D., Rinaldi G., Brindley P.J., Yang H., Wang J.,
RA Wang J., Gasser R.B.;
RT "Whole-genome sequence of Schistosoma haematobium.";
RL Nat. Genet. 44:221-225(2012).
RN [2] {ECO:0000313|EMBL:KAF1324124.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=31494670;
RA Stroehlein A.J., Korhonen P.K., Chong T.M., Lim Y.L., Chan K.G.,
RA Webster B., Rollinson D., Brindley P.J., Gasser R.B., Young N.D.;
RT "High-quality Schistosoma haematobium genome achieved by single-molecule
RT and long-range sequencing.";
RL Gigascience 8:0-0(2019).
RN [3] {ECO:0000313|EMBL:KAH9593713.1}
RP NUCLEOTIDE SEQUENCE.
RA Stroehlein A.J.;
RT "Chromosome-level genome assembly for S. haematobium.";
RL Submitted (JUN-2021) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:KAH9593713.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=35167626;
RA Stroehlein A.J., Korhonen P.K., Lee V.V., Ralph S.A., Mentink-Kane M.,
RA You H., McManus D.P., Tchuente L.T., Stothard J.R., Kaur P., Dudchenko O.,
RA Aiden E.L., Yang B., Yang H., Emery A.M., Webster B.L., Brindley P.J.,
RA Rollinson D., Chang B.C.H., Gasser R.B., Young N.D.;
RT "Chromosome-level genome of Schistosoma haematobium underpins genome-wide
RT explorations of molecular variation.";
RL PLoS Pathog. 18:0-0(2022).
CC -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC doublet microtubules (DMTs) in cilia axoneme, which is required for
CC motile cilia beating. {ECO:0000256|ARBA:ARBA00035003}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000256|ARBA:ARBA00004430}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAF1324124.1}.
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DR EMBL; AMPZ02000393; KAF1324124.1; -; Genomic_DNA.
DR EMBL; AMPZ03000001; KAH9593713.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A6A5D7B1; -.
DR EnsemblMetazoa; XM_012940467.2; XP_012795921.2; MS3_0018916.
DR OrthoDB; 160134at2759; -.
DR Proteomes; UP000471633; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR Gene3D; 2.30.29.170; -; 3.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR006602; DM10_dom.
DR InterPro; IPR049246; DUF5580_M.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR040193; EFHC1/EFHC2/EFHB.
DR PANTHER; PTHR12086; EF-HAND DOMAIN C-TERMINAL CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12086:SF11; EF-HAND DOMAIN-CONTAINING FAMILY MEMBER C2; 1.
DR Pfam; PF06565; DM10_dom; 3.
DR Pfam; PF20742; DUF5580_M; 1.
DR SMART; SM00676; DM10; 3.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS51336; DM10; 3.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000471633}.
FT DOMAIN 75..182
FT /note="DM10"
FT /evidence="ECO:0000259|PROSITE:PS51336"
FT DOMAIN 226..365
FT /note="DM10"
FT /evidence="ECO:0000259|PROSITE:PS51336"
FT DOMAIN 428..535
FT /note="DM10"
FT /evidence="ECO:0000259|PROSITE:PS51336"
SQ SEQUENCE 768 AA; 89300 MW; F7C25F2CD3EEAB9B CRC64;
MALPFLPGYS FNRNIGKEKF HKSHYLKLEG DKAYMHGDDK PGIGGEKLPG QRIDAPTSVY
PSGMGSQFPA WLAFDKQALS FDAYFQESVN ERREEQYRIR KCKILFYPED DTIQVVEPRI
ANTGMAQGTI IKRHRISKPV PNEHLYYTVH DFNVGTEFVA YGKTFRIVSC DQFTSNFLRK
LGIKLGKPES IPDDPYSIHR KAFTESMQPL RPYERMDKLR QFLDHDRHVL RFFCFWDDTE
SLYGDPREMI LNYFLADDTI EIREIIPANS GRDAVPCFLR RQKLPRTIAS IPLPGVVTDR
TLLNVFGHPQ RGGHYILDSL KLGAPKDNFY KDHDLTIGAN INVYGRKFLI CDCDEFTKEY
YRIKYGIQDF TPVKPKLQDH ITTVKREIPP YNGWGTDEDS LANCYSLIPK APNHNFKKFM
ELDRQGLESH VLRFAGRLLS DRPTDRDRQF VISCYLSDDT ISIFEPQQKN SGFQGGLFLE
RSKIKKPDSK LFDNKPMEYY KPTDLYVGAK LDFNTFLFEL TEADDYTLDY MEKHKTQFEQ
ADYQLILNKL ITILNNEQCD EIIKYAVNQD PDDTGTFDFD QMINLINQLT GKENALTTHE
LGTLARHYGV RPSKEINLEI LLGIAQQTLR RKAFEDFSSL MIACRQQDAD KTGEMDRHAI
RRICLAHHLP LPDDMLNSLM NCLVNQNNLI QYEQFINQLN WKNYEIKELS IQQSLDYIEN
MNIDWLPISK GDMPKSINLS KKSKIDKINY KQLINDLFMK NLFHSSID
//
