ID A0A6A5DPZ4_SCHHA Unreviewed; 1005 AA.
AC A0A6A5DPZ4;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 08-NOV-2023, entry version 9.
DE SubName: Full=Phosphatidylcholine-sterol acyltransferase (Lecithin-cholesterol acyltransferase)/ Phospholipase A {ECO:0000313|EMBL:KAF1337926.1};
GN ORFNames=MS3_0016322 {ECO:0000313|EMBL:KAF1337926.1};
OS Schistosoma haematobium (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6185 {ECO:0000313|EMBL:KAF1337926.1};
RN [1] {ECO:0000313|EMBL:KAF1337926.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22246508; DOI=10.1038/ng.1065;
RA Young N.D., Jex A.R., Li B., Liu S., Yang L., Xiong Z., Li Y.,
RA Cantacessi C., Hall R.S., Xu X., Chen F., Wu X., Zerlotini A., Oliveira G.,
RA Hofmann A., Zhang G., Fang X., Kang Y., Campbell B.E., Loukas A.,
RA Ranganathan S., Rollinson D., Rinaldi G., Brindley P.J., Yang H., Wang J.,
RA Wang J., Gasser R.B.;
RT "Whole-genome sequence of Schistosoma haematobium.";
RL Nat. Genet. 44:221-225(2012).
RN [2] {ECO:0000313|EMBL:KAF1337926.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=31494670;
RA Stroehlein A.J., Korhonen P.K., Chong T.M., Lim Y.L., Chan K.G.,
RA Webster B., Rollinson D., Brindley P.J., Gasser R.B., Young N.D.;
RT "High-quality Schistosoma haematobium genome achieved by single-molecule
RT and long-range sequencing.";
RL Gigascience 8:0-0(2019).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAF1337926.1}.
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DR EMBL; AMPZ02000102; KAF1337926.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A6A5DPZ4; -.
DR EnsemblMetazoa; XM_012941667.2; XP_012797121.2; MS3_0016322.
DR OrthoDB; 353098at2759; -.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0008374; F:O-acyltransferase activity; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR003386; LACT/PDAT_acylTrfase.
DR InterPro; IPR000719; Prot_kinase_dom.
DR PANTHER; PTHR11440:SF97; BCDNA.GH02384; 1.
DR PANTHER; PTHR11440; LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED; 1.
DR Pfam; PF02450; LCAT; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000313|EMBL:KAF1337926.1};
KW Transferase {ECO:0000313|EMBL:KAF1337926.1}.
FT DOMAIN 1..129
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 293..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1005 AA; 115674 MW; 8B64295ED005088D CRC64;
MQSRSNGNIK VGDFGISRSL ATTEELATTF IGTPYYMSPE VLKYEGYNNK SDIWSIGIIL
YELCTQRRAF TGTNLMRVMW QVINDPCPQL PEIYSKELQE VLELMLKKTP QERPSASELL
HSNAVHSYLR DLYKEIIIHM RNELSGENRK DGSEFNLLMS FEEFISLPDS VLHKQQSIEN
AEKFSIQLNE EIEENVEHSE DQYLTPRQKI ELNKATESDR TTAVLRDLAE QLTHTRNSLN
STMETQLFTW QKGYPSLNHI WPTIQIPTEK LLNELKNLYL EKINNETSLI DELDDDLENE
DNKKLPGKGP GAEDESLGTF NFLNSTKHRN EEIEDLTNNM SFTEIKNFYP SPRLTSPIYD
YVTMDEFKKQ VDIDNNPNII KKGNNNQEAL FIRRQFTFPA MLNQNYAQSA RQLSDINSSK
LKCNSVFTDD TQLMETYYTN YDNELLNYTN NFNKEDLKEL IENENILQND LEDIENQDNV
DSNETLNDVL VCMKAALCHP EDSNTIVLDD EAKTIFSPEA KAKRIDALKK YCIDKLGEKE
FHNAYHYLYE KRILEKNQSG ELTILNGLKS YCSDVTTGFL LDHLLFLEND AVKQTINIQL
SESVHQILND DLSFYALITW AVNSESTSNG QYPLVMIPGT AGCQAFAVLK NDPNHKALPV
WLNLEFFTFI KHFTEYFKLQ YDPKTGHSYD AEGVDIIFPG WGETWSIENL DERPNMFSEY
FGSLVNALRK DPFYVSNFTM RGAPYDFRKA PNENGEFFNK LKALIEETYE NAKQRPVVLL
PHSMGCLFAQ WFLKKCDIPW KKKYIKSLVF SSCPFGGSVK TVKIEASGDN FGVFLRSPLS
FRHVQRSMPS LPFLFPDSRL WPSSEPLIIT PTTNYSSADY ERFFKDINYT IGYQMWKDTH
SLVDGLEMPT GIDDIYCIHG SRLSTTEKIS YSAPSYFYSG FPDQVPLLIP GDGDGTVGIR
SLEYCKNWPG IKYYILPGAE HVRILSDARH INIILKILNA NITHE
//
