ID A0A6A5DU92_PERFL Unreviewed; 1379 AA.
AC A0A6A5DU92;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 13-SEP-2023, entry version 10.
DE RecName: Full=I/LWEQ domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PFLUV_G00205100 {ECO:0000313|EMBL:KAF1377857.1};
OS Perca fluviatilis (European perch).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Percoidei; Percidae; Percinae; Perca.
OX NCBI_TaxID=8168 {ECO:0000313|EMBL:KAF1377857.1, ECO:0000313|Proteomes:UP000465112};
RN [1] {ECO:0000313|EMBL:KAF1377857.1, ECO:0000313|Proteomes:UP000465112}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:KAF1377857.1};
RA Roques C., Zahm M., Cabau C., Klopp C., Bouchez O., Donnadieu C., Kuhl H.,
RA Gislard M., Guendouz S., Journot L., Haffray P., Bestin A., Morvezen R.,
RA Feron R., Wen M., Jouanno E., Herpin A., Schartl M., Postlethwait J.,
RA Schaerlinger B., Chardard D., Lecocq T., Poncet C., Jaffrelo L.,
RA Lampietro C., Guiguen Y.;
RT "A chromosome-scale genome assembly of the European perch, Perca
RT fluviatilis.";
RL Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the SLA2 family.
CC {ECO:0000256|ARBA:ARBA00010135}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAF1377857.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; VHII01000017; KAF1377857.1; -; Genomic_DNA.
DR OrthoDB; 7775at2759; -.
DR Proteomes; UP000465112; Chromosome 17.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:InterPro.
DR Gene3D; 1.20.5.1700; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 6.10.250.920; -; 2.
DR Gene3D; 1.20.1410.10; I/LWEQ domain; 1.
DR InterPro; IPR011417; ANTH_dom.
DR InterPro; IPR013809; ENTH.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR032422; HIP1_clath-bd.
DR InterPro; IPR035964; I/LWEQ_dom_sf.
DR InterPro; IPR002558; ILWEQ_dom.
DR InterPro; IPR030224; Sla2_fam.
DR PANTHER; PTHR10407; HUNTINGTIN INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR10407:SF10; HUNTINGTIN-INTERACTING PROTEIN 1-RELATED PROTEIN; 1.
DR Pfam; PF07651; ANTH; 1.
DR Pfam; PF16515; HIP1_clath_bdg; 2.
DR Pfam; PF01608; I_LWEQ; 1.
DR SMART; SM00273; ENTH; 1.
DR SMART; SM00307; ILWEQ; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF109885; I/LWEQ domain; 1.
DR PROSITE; PS50942; ENTH; 1.
DR PROSITE; PS50945; I_LWEQ; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000465112}.
FT DOMAIN 19..147
FT /note="ENTH"
FT /evidence="ECO:0000259|PROSITE:PS50942"
FT DOMAIN 861..1102
FT /note="I/LWEQ"
FT /evidence="ECO:0000259|PROSITE:PS50945"
FT REGION 1102..1379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 362..396
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 470..666
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1116..1130
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1132..1291
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1292..1306
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1307..1363
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1379 AA; 154012 MW; B5D404D716F5A656 CRC64;
MSKTKTKSDN KTEKALAAEK EQFNKQQLHN ISKTLISGET PLKEKYVRNI IMGTHKEGGA
STFWSYTLNL PLSSNSMISW KFCYLLHKVL RDGHRNAVRD SHRYCRNVKD MGILWGNLHD
RYGHIVALSA KFLCLKMEFH AKHKVIPANL EASDETFDRE TGSDVTKVLD ITQELMDYWD
AGLKMEETVL RQLDANGAKS TTPAGQCRLT PLIPLILDCS LLYHFSVLSM FKLHSRIAPD
VLLGHRERFR DLFNSLTQFF DRARETEFFK TIIQIPDLPD EPPNFLRASA LAEYKKPVVV
MPNEERHNEE EVEMQPELRE APQYYMLSQM GGPDASAEQR ETENESLKRE LQVLKPELQL
IKTEAQRCLT ELKAQVNRLE AEVDEQRTQK QMAMMEKEHL RMEVEALRCT NVANVGAQIG
FKEADHRAQA AELRFAQLKE RHAELITSHA DLMKKNAETV KLLSGTQHGQ DDLLKYKQQL
ENELENLRQE KRNTTSQQQQ EVQRLNTELL EQRAELALLR STLDNKDKEG SQVSSSLAAL
QAERDVLLRS AREKDAELSS LRQQAQQQQG SLDLERERLQ RELEALRAQL QQQLAINAEQ
KLEIDRLRRE LDSTRAELNR ANSALQSKEM SGTQLSSSVA GLQAEREALL RSMRDQEGEL
NSLRQQAQLH HSSLEQERQR SSVELGNLHA QLQQQACREA ELSKKLQDEQ FCLLQCAVVE
AEGIILDAVA KLDDPIHVSC ICSPDYLVNR ADITLRSIDK IQQSHVVYLG NRNDASGLLR
SVTQFSHLAA DTIVNGSATS HSAPTDQADR LTDSCRDCAN HCLQFLKDLK LQASLQRADP
SAVRYTVQRI LALGQDLRPK GQDVMKGELA YMVDKEMSAT STAIEEAVLR MDEILNQAKR
ETSGIKLEVN QSILGSCSDL MKAVHMLVTA STDLQKDIVE GGRGAASVTE FYAKNSRWTE
GLISASKAVG WGATQLLDSA DRVVGEKGTY EELIACSHEI AASTAQLVAA SKVKADRNNK
KLNTLKQASR HVNDMAAVVV TSTKHGQQQI SDQGVMDFSG MSLIKLKTEE MEVQVKVLQL
ESQLEQERVR LGELRKRHYK LDASGDDGAD AEDGADSFPP PPPPTLLECA PVPPSFSQTQ
PYLNTQSYAA SNPFAPAQTP TQSFSVPQSY TQTNTYTPSQ TSIPSQTYTP SQTSIPSQTY
TPSQTSIPSQ TYTPSQTSIP SQTYTPSQTS IPSQTYTPSQ TSIPSQTYTP SQTSIPSQTY
TPSQTSIPSQ TYTPSQTSIP SQTYTPSQSF IPTQPYTPPQ PFTPNPTQTY LKPQSYSLSA
PSTNPSSLSR PQSPSLPRAS PQNNTESTKP ASRKPSIFTK SGNLLKNAFK RGETGTGES
//
