ID   A0A6A5E184_PERFL        Unreviewed;       984 AA.
AC   A0A6A5E184;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   27-MAR-2024, entry version 10.
DE   RecName: Full=PKD domain-containing protein {ECO:0000259|PROSITE:PS50093};
GN   ORFNames=PFLUV_G00158200 {ECO:0000313|EMBL:KAF1381841.1};
OS   Perca fluviatilis (European perch).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Percoidei; Percidae; Percinae; Perca.
OX   NCBI_TaxID=8168 {ECO:0000313|EMBL:KAF1381841.1, ECO:0000313|Proteomes:UP000465112};
RN   [1] {ECO:0000313|EMBL:KAF1381841.1, ECO:0000313|Proteomes:UP000465112}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Blood {ECO:0000313|EMBL:KAF1381841.1};
RA   Roques C., Zahm M., Cabau C., Klopp C., Bouchez O., Donnadieu C., Kuhl H.,
RA   Gislard M., Guendouz S., Journot L., Haffray P., Bestin A., Morvezen R.,
RA   Feron R., Wen M., Jouanno E., Herpin A., Schartl M., Postlethwait J.,
RA   Schaerlinger B., Chardard D., Lecocq T., Poncet C., Jaffrelo L.,
RA   Lampietro C., Guiguen Y.;
RT   "A chromosome-scale genome assembly of the European perch, Perca
RT   fluviatilis.";
RL   Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KAF1381841.1}.
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DR   EMBL; VHII01000013; KAF1381841.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A6A5E184; -.
DR   Proteomes; UP000465112; Chromosome 13.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd00146; PKD; 3.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR029865; KIAA0319-like.
DR   InterPro; IPR022409; PKD/Chitinase_dom.
DR   InterPro; IPR002859; PKD/REJ-like.
DR   InterPro; IPR000601; PKD_dom.
DR   InterPro; IPR035986; PKD_dom_sf.
DR   PANTHER; PTHR46182:SF3; DYSLEXIA-ASSOCIATED PROTEIN KIAA0319-LIKE PROTEIN; 1.
DR   PANTHER; PTHR46182; FI19480P1; 1.
DR   Pfam; PF02010; REJ; 1.
DR   SMART; SM00089; PKD; 4.
DR   SUPFAM; SSF49299; PKD domain; 4.
DR   PROSITE; PS50093; PKD; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000465112};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        862..887
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          451..524
FT                   /note="PKD"
FT                   /evidence="ECO:0000259|PROSITE:PS50093"
FT   REGION          133..168
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          189..223
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          908..984
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        146..168
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   984 AA;  107070 MW;  62C9CC338F65F61D CRC64;
     MSAGVDLPSP VTSQHLAANL TPRSLFLPAS FSSTTWLGER SLFLVENVLF TPQAAHLELT
     SPPPTADLPL GLGFSCRCVS KSLPGDWGGT GDSLEQHRQH GCSQNRGCPI TTLPQPHQES
     LGLLQLLSKS PVVTARRRRA RRAQHAGTPN TGQLNSTESP KPKTARLSPT VPSTITLLQT
     AQKNLSQLDN GSADIAPAPS QQNSTDTVNT AASSNSSDVS TPTATAATAT VTTPTQAVRE
     LVVSAGESVE VTLPRNKVEL NAFVVPPPPT ETTYAFDWRL ITHPKDYSGQ MEGQHSMTLK
     LSQLTVGLYE FEVTVNGEGA HGEGYVNVTV KPEPRVNKRP VAVVSPKFQE ISLPTSSTVI
     DGSQSTDDDK VVAWHWEEVK GPLREEKVSA DTPVLTLTNL VPGNYTFSLT VTDSDRATNS
     TQATLTVNKA KDYRPVANAG PNQVIQLPRN SITLYGNQST DDHDSLSYEW SLSPESKDKV
     VEMQGVRTPI LQLSAMQEGD YTFQLTVTDS AGQQETAQVT VIVQPENNKP PVADAGPEKE
     LTLPVDRTTL DGSKSSDDQK IATYHWKQTN GPDGVKIENA DGAVATVTGL EVGTYEFTLT
     VTDDRKLQSS DTVTVIVREE LDQPPVAHVV SSPSITLPVR TCTLDGSHST DDKGGVSYLW
     TRDDSSPAAG DVLNNSDHQA VLFLGNLVEG KYGFILTVTD SKGQTSTDRG TVEVKPDVWK
     RDLVELVLEV SVSQVSHRQR DMLLRQVGVL LGVLDSDIIV REISAFNEHS TRLVFLVSGG
     PGRPPLSGRS VALSLRNKLR KQKNDFLIYK ARRVDTVICQ LNCSSHGDCD SYTRRCVCHP
     FWMENFIRAQ LGDAESNCEW SVLYVTIASF MIVVAIATVV WGMVCCCKRR KSKVRRSKSR
     YKMLEADEQD SLELQPPRAA RIKPVPAPTS SALMHSDSDL DSDEGQGGVP WTEQERGHLL
     RPQNGSLRNG QGPGRGRKQR EELL
//