ID   A0A6A5EM33_PERFL        Unreviewed;       664 AA.
AC   A0A6A5EM33;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   22-FEB-2023, entry version 9.
DE   RecName: Full=Tetratricopeptide repeat protein 30 {ECO:0000256|RuleBase:RU367070};
GN   ORFNames=PFLUV_G00181450 {ECO:0000313|EMBL:KAF1379955.1};
OS   Perca fluviatilis (European perch).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Percoidei; Percidae; Percinae; Perca.
OX   NCBI_TaxID=8168 {ECO:0000313|EMBL:KAF1379955.1, ECO:0000313|Proteomes:UP000465112};
RN   [1] {ECO:0000313|EMBL:KAF1379955.1, ECO:0000313|Proteomes:UP000465112}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Blood {ECO:0000313|EMBL:KAF1379955.1};
RA   Roques C., Zahm M., Cabau C., Klopp C., Bouchez O., Donnadieu C., Kuhl H.,
RA   Gislard M., Guendouz S., Journot L., Haffray P., Bestin A., Morvezen R.,
RA   Feron R., Wen M., Jouanno E., Herpin A., Schartl M., Postlethwait J.,
RA   Schaerlinger B., Chardard D., Lecocq T., Poncet C., Jaffrelo L.,
RA   Lampietro C., Guiguen Y.;
RT   "A chromosome-scale genome assembly of the European perch, Perca
RT   fluviatilis.";
RL   Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for polyglutamylation of axonemal tubulin. Plays a
CC       role in anterograde intraflagellar transport (IFT), the process by
CC       which cilia precursors are transported from the base of the cilium to
CC       the site of their incorporation at the tip.
CC       {ECO:0000256|RuleBase:RU367070}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC       {ECO:0000256|ARBA:ARBA00004138, ECO:0000256|RuleBase:RU367070}.
CC   -!- SIMILARITY: Belongs to the TTC30/dfy-1/fleer family.
CC       {ECO:0000256|ARBA:ARBA00009522, ECO:0000256|RuleBase:RU367070}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KAF1379955.1}.
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DR   EMBL; VHII01000015; KAF1379955.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A6A5EM33; -.
DR   OrthoDB; 5477075at2759; -.
DR   Proteomes; UP000465112; Chromosome 15.
DR   GO; GO:0005879; C:axonemal microtubule; IEA:UniProtKB-UniRule.
DR   GO; GO:0042073; P:intraciliary transport; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR039941; TT30.
DR   PANTHER; PTHR20931:SF0; TETRATRICOPEPTIDE REPEAT PROTEIN 30; 1.
DR   PANTHER; PTHR20931; UNCHARACTERIZED; 1.
DR   Pfam; PF13174; TPR_6; 2.
DR   SMART; SM00028; TPR; 5.
DR   SUPFAM; SSF48452; TPR-like; 2.
DR   PROSITE; PS50005; TPR; 1.
PE   3: Inferred from homology;
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273,
KW   ECO:0000256|RuleBase:RU367070};
KW   Cilium {ECO:0000256|ARBA:ARBA00023069, ECO:0000256|RuleBase:RU367070};
KW   Cilium biogenesis/degradation {ECO:0000256|ARBA:ARBA00022794,
KW   ECO:0000256|RuleBase:RU367070}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000465112};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339,
KW   ECO:0000256|RuleBase:RU367070}.
FT   REPEAT          40..73
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   COILED          367..394
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   664 AA;  76606 MW;  61ABDD24124468BA CRC64;
     MTTIKDGEYT STIYKLIKDG QYVEAIHILN GQLQKHTKSR AALSLLGYCY YHIQDFTNSA
     ECYEQLTQLH PEVEEYKVYF AQSLYKAGAY PEATKASFVL DNPSSHIKMV KLQACIKYCE
     EDYSTAKSLL EQLPQDDPDY AYNMGCLLYQ DGKYEEACKK FTSAMQVLGY VPALSYNIAL
     CYYSLKNYAQ ALKYIGEIIE RGIREHPELS VGMTTEGIDV HSVGNTLVLH QTALIEAFNL
     KAAIEYQLKN LKGAQEALTD MPPRSEEELD PVTLHNQALV NMDTKPSEGF EKLAFLLQQP
     SFPPVNFGNL LLLYCKHEYF DLAADVLAEN AHLTYKFLSP YMYEFLDALL TCQTAPEEAF
     RKFDEMNGKL TEQLRKLAKQ VQEARLARDD EAQKKTLQDY DLMQEKYIVV LMAQAKIYWN
     RENFQMVEKI FRKSVEVCNE DDTWKLNVAH VLFMQNKYKE AIGFYEPIVK KHYDNVEQCN
     IQECPCKCKP SILNVSAVVL ANLCVSYILT SQNEEAEELM RKIEKEEEQI SYDDPDKKVF
     HLCIVNLVIG TLYCAKGNYD FGISRVIKSL EPYNKKLGTD TWFYAKRCFL SLLENMSKHM
     VMLRDAVVQE CIQFLEHCEV YGKEVPAIIE QPLEEHRIHI GKNTVTYEAR LLKALFYEVI
     GWNK
//