ID A0A6A5ETD4_PERFL Unreviewed; 835 AA.
AC A0A6A5ETD4;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 24-JAN-2024, entry version 11.
DE RecName: Full=Neurofilament medium polypeptide {ECO:0000256|ARBA:ARBA00015894};
DE AltName: Full=160 kDa neurofilament protein {ECO:0000256|ARBA:ARBA00030258};
DE AltName: Full=Neurofilament triplet M protein {ECO:0000256|ARBA:ARBA00032778};
GN ORFNames=PFLUV_G00200050 {ECO:0000313|EMBL:KAF1377372.1};
OS Perca fluviatilis (European perch).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Percoidei; Percidae; Percinae; Perca.
OX NCBI_TaxID=8168 {ECO:0000313|EMBL:KAF1377372.1, ECO:0000313|Proteomes:UP000465112};
RN [1] {ECO:0000313|EMBL:KAF1377372.1, ECO:0000313|Proteomes:UP000465112}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:KAF1377372.1};
RA Roques C., Zahm M., Cabau C., Klopp C., Bouchez O., Donnadieu C., Kuhl H.,
RA Gislard M., Guendouz S., Journot L., Haffray P., Bestin A., Morvezen R.,
RA Feron R., Wen M., Jouanno E., Herpin A., Schartl M., Postlethwait J.,
RA Schaerlinger B., Chardard D., Lecocq T., Poncet C., Jaffrelo L.,
RA Lampietro C., Guiguen Y.;
RT "A chromosome-scale genome assembly of the European perch, Perca
RT fluviatilis.";
RL Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAF1377372.1}.
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DR EMBL; VHII01000017; KAF1377372.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A6A5ETD4; -.
DR Proteomes; UP000465112; Chromosome 17.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR006821; Intermed_filament_DNA-bd.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR45652; GLIAL FIBRILLARY ACIDIC PROTEIN; 1.
DR PANTHER; PTHR45652:SF3; NEUROFILAMENT MEDIUM POLYPEPTIDE; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF04732; Filament_head; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000465112}.
FT DOMAIN 94..405
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 463..776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 815..835
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 175..248
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 289..369
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 13..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 467..502
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 524..575
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 576..601
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 616..685
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 701..759
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 835 AA; 93213 MW; A851A2D235B6A495 CRC64;
MSYPVDTVGS PFRRTMDTRT TGYGYSRSGG TPSSGFRSQS WSRASPGSTM TTSYKRTVNM
PVSRAYGSTV LSSADSVDYS QTSILNGDYK RSSEKEQLQG LNDRFAVYID KVHYLEQQNT
QIESEIQALR QKQVSRSQLG DVYDQELQEL RSMLEQIHHD KAQIQLDTDH IDEDIQRLRD
RLDEEARIRE ETEAIIRALR KETGDSKLVK SELDKKVQSL QDEIAYIRNN HEEEVSELIA
QIQESQVTMK RQDLQKTDIT EALREIRCEL EGHSNQNLQQ VENWFMCRYA KLTEAAEQNK
DAIKSARDEI SDYRRQLQSK TVELESVRGT RDSLERQLND IEDRHNSDLS SLQETIHQMD
NELKSTKWEM ARHLREYQDL LNVKMALDIE IAAYRKLLEG EETHFSTFPY RQTVTPTRIS
KSEPPKFKVQ HKFVEEIIEE TRVEDEKSEM DQALEDIAQE LSATLGGGGD EEDEGEEVGE
GEEEEAEGAG EEGEEGEGEE EEVVAATEAK VSSSAPAKEE EEAEEDVKGG DEEEEGEGEG
GEEGEKEEEG EGGDKEKGDD AEEGEEGEEG DEEVEETVLC SKAPESKATP DKEKAGDKEG
EEDAGAEEDG GDQDEDAGGE KASKSGDEKE EKEDADKGKK DDSEKDEKKV KDEKADDKSE
EAVAKTEAPK TEAAKPEEAA KTEASKPDSP KPASPKSESP KTETAKPEAP KAAEEKSEKK
SDSTDKKVEK KDVAMNGDLD KSSPEEIEKK DEGKEGDVIA NGVDESPSKE DGSQKVVITK
TVETITTGED GSKHVTKSVT VTETMKEEVE EVMQVSTKKT EKHSTQSIKQ VTEAE
//
