ID A0A6A5FCV0_PERFL Unreviewed; 1024 AA.
AC A0A6A5FCV0;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 13-SEP-2023, entry version 9.
DE RecName: Full=MCF.2 cell line derived transforming sequence-like 2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=PFLUV_G00113610 {ECO:0000313|EMBL:KAF1386002.1};
OS Perca fluviatilis (European perch).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Percoidei; Percidae; Percinae; Perca.
OX NCBI_TaxID=8168 {ECO:0000313|EMBL:KAF1386002.1, ECO:0000313|Proteomes:UP000465112};
RN [1] {ECO:0000313|EMBL:KAF1386002.1, ECO:0000313|Proteomes:UP000465112}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:KAF1386002.1};
RA Roques C., Zahm M., Cabau C., Klopp C., Bouchez O., Donnadieu C., Kuhl H.,
RA Gislard M., Guendouz S., Journot L., Haffray P., Bestin A., Morvezen R.,
RA Feron R., Wen M., Jouanno E., Herpin A., Schartl M., Postlethwait J.,
RA Schaerlinger B., Chardard D., Lecocq T., Poncet C., Jaffrelo L.,
RA Lampietro C., Guiguen Y.;
RT "A chromosome-scale genome assembly of the European perch, Perca
RT fluviatilis.";
RL Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAF1386002.1}.
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DR EMBL; VHII01000009; KAF1386002.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A6A5FCV0; -.
DR Proteomes; UP000465112; Chromosome 9.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01227; PH_Dbs; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd00170; SEC14; 1.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 1.20.58.60; -; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR035534; DBS_PH.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR PANTHER; PTHR22826:SF201; GUANINE NUCLEOTIDE EXCHANGE FACTOR MCF2L2-RELATED; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000465112}.
FT DOMAIN 94..194
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT DOMAIN 625..804
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 816..938
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 525..590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 554..579
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1024 AA; 117370 MW; 932AF86FFA1FC815 CRC64;
MLCWLREDEM SVQELLQRVQ CVITHVDEIM QQEIRPLLSV DIIEQLHRQF ALLSGGRGKD
GAPIIIFPEY SGFSDVPEED FLNVVTYLTS IPSLDAASIG FIIIIDRRKD KWSSVKASLS
RIAGAFPGNL QLVLVLRPSR FFQRAIADIG IKLHKDDFKM KVPIVMLNSL SDLHGYVDKS
QLTRELGGSL EYCHSQWIHH RTAVENFAMT VKTTAQMLQK FGTDLAETEL PNDVQCTKDL
LIAHTDKHNN LKDELKLALK QGTTLLDCIK EQAAKSENHK LNPDEMENQT TVERLLAQLD
ETENAFEQFW CKHHLKLEQC LQLRHFEQDF REMKVSLDSL MDSLTSLPDT GDCVARDEHL
LKDLKKLEEK ALPTLEKAQL HALHGDQLIQ SNHYAVDSIR PKCVELRRVC DDFSNESKKK
TDVLSKSLQI HMGIDKVTQW CESGIYMLAF QAVDKCQSQE GAESALIDIE HFLESAEKNQ
LTELKNLHNL YDVVLSEDIK ANVLKALKRL EDVQEMFQKR HVSLKRLSAK QMRPVQPVAP
RPESSPKRPV LKNPPRTTGS QQPLARRASD NSNSGKQPAE ADPSKKKNIR KAKGGIKIEV
MHEKSQGGST HVVVTNETEE SLSNRRRHIM TELIETERLY VEELQSIMEG YFAELDNSEL
SHLIPPSVGN RRDVLFGNLP EIYEFHNRTF LRELENCAEK PELVGTCFLK RKEELKVYEK
YCQNKPRSEV LWRQCGDSLF FQECQKKLDH KLSLDAYLLK PVQRITKYQL MLKEMLKCSK
GDGTAELEEA LTTMLDIIKS VNDSMHQIAI TGFEGNLSEL GKLLMQGSFN VWTDHKKGHS
KVKDLARFKP MQRHLFLYDK MMLFCKKREE ITDGHEKTPS YSFKHSLKMS AVGITENVKG
DIKKFEVWYN GREEVYIIQA PSMDVKNMWV SEIRKVLTGQ LEACREASQL NIYGVPMRNV
RKMALRQSDS SSPELCFRRT NPSPNMRQKK VIENINMLCR YGESRTIPSF FPPSFPSITS
SPIT
//