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Database: UniProt
Entry: A0A6A6L4P3_HEVBR
LinkDB: A0A6A6L4P3_HEVBR
Original site: A0A6A6L4P3_HEVBR 
ID   A0A6A6L4P3_HEVBR        Unreviewed;       329 AA.
AC   A0A6A6L4P3;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   13-SEP-2023, entry version 10.
DE   RecName: Full=Cysteine proteinase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=GH714_031279 {ECO:0000313|EMBL:KAF2295053.1};
OS   Hevea brasiliensis (Para rubber tree) (Siphonia brasiliensis).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Micrandreae;
OC   Hevea.
OX   NCBI_TaxID=3981 {ECO:0000313|EMBL:KAF2295053.1, ECO:0000313|Proteomes:UP000467840};
RN   [1] {ECO:0000313|EMBL:KAF2295053.1, ECO:0000313|Proteomes:UP000467840}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. GT1 {ECO:0000313|Proteomes:UP000467840};
RC   TISSUE=Leaf {ECO:0000313|EMBL:KAF2295053.1};
RX   PubMed=31838037; DOI=10.1016/j.molp.2019.10.017;
RA   Liu J., Shi C., Shi C.C., Li W., Zhang Q.J., Zhang Y., Li K., Lu H.F.,
RA   Shi C., Zhu S.T., Xiao Z.Y., Nan H., Yue Y., Zhu X.G., Wu Y., Hong X.N.,
RA   Fan G.Y., Tong Y., Zhang D., Mao C.L., Liu Y.L., Hao S.J., Liu W.Q.,
RA   Lv M.Q., Zhang H.B., Liu Y., Hu-Tang G.R., Wang J.P., Wang J.H., Sun Y.H.,
RA   Ni S.B., Chen W.B., Zhang X.C., Jiao Y.N., Eichler E.E., Li G.H., Liu X.,
RA   Gao L.Z.;
RT   "The Chromosome-Based Rubber Tree Genome Provides New Insights into Spurge
RT   Genome Evolution and Rubber Biosynthesis.";
RL   Mol. Plant 13:336-350(2020).
CC   -!- SIMILARITY: Belongs to the peptidase C1 family.
CC       {ECO:0000256|ARBA:ARBA00008455}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KAF2295053.1}.
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DR   EMBL; JAAGAX010000013; KAF2295053.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A6A6L4P3; -.
DR   Proteomes; UP000467840; Chromosome 7.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd02248; Peptidase_C1A; 1.
DR   Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR025661; Pept_asp_AS.
DR   InterPro; IPR000169; Pept_cys_AS.
DR   InterPro; IPR025660; Pept_his_AS.
DR   InterPro; IPR013128; Peptidase_C1A.
DR   InterPro; IPR000668; Peptidase_C1A_C.
DR   InterPro; IPR039417; Peptidase_C1A_papain-like.
DR   InterPro; IPR013201; Prot_inhib_I29.
DR   PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR   PANTHER; PTHR12411:SF824; PAPAIN FAMILY CYSTEINE PROTEASE; 1.
DR   Pfam; PF08246; Inhibitor_I29; 1.
DR   Pfam; PF00112; Peptidase_C1; 1.
DR   PRINTS; PR00705; PAPAIN.
DR   SMART; SM00848; Inhibitor_I29; 1.
DR   SMART; SM00645; Pept_C1; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR   PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR   PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000467840};
KW   Thiol protease {ECO:0000256|ARBA:ARBA00022807}.
FT   DOMAIN          23..80
FT                   /note="Cathepsin propeptide inhibitor"
FT                   /evidence="ECO:0000259|SMART:SM00848"
FT   DOMAIN          109..326
FT                   /note="Peptidase C1A papain C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00645"
SQ   SEQUENCE   329 AA;  36451 MW;  1E3911F63FADA370 CRC64;
     MADLVSSRKL YLHDQSSSMD ERHELWMKKY GRVYRDKAEK ERRFEIFKHN VKFIESFNAA
     GNKSYKLRIN KFADLSNDEF KASHNGYRRS EQTRSMKATS FKYANVTGLP ASMDWRKQGA
     VTPVKDQGDC GCCWAFSTVA AIEGIHKITT GKLISLSEQE LVDCDTKGKD EGCNGGYMED
     GFKFIMENQG ITSEANYPYK ATNGTCNPNK EASHIAKITG YETVPANSEA SLMKAVAQQP
     VSVSIDAGGL SFQFYSSGVF KGECGNILNH GVTAVGYGTT SDGTKYWLVK NSWGADWGEQ
     GYIRMHKDVF AKEGLCGIAM DSSYPTANA
//
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