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Database: UniProt
Entry: A0A6A6M2E5_HEVBR
LinkDB: A0A6A6M2E5_HEVBR
Original site: A0A6A6M2E5_HEVBR 
ID   A0A6A6M2E5_HEVBR        Unreviewed;       503 AA.
AC   A0A6A6M2E5;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   RecName: Full=peroxidase {ECO:0000256|ARBA:ARBA00012313};
DE            EC=1.11.1.7 {ECO:0000256|ARBA:ARBA00012313};
GN   ORFNames=GH714_019035 {ECO:0000313|EMBL:KAF2306523.1};
OS   Hevea brasiliensis (Para rubber tree) (Siphonia brasiliensis).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Micrandreae;
OC   Hevea.
OX   NCBI_TaxID=3981 {ECO:0000313|EMBL:KAF2306523.1, ECO:0000313|Proteomes:UP000467840};
RN   [1] {ECO:0000313|EMBL:KAF2306523.1, ECO:0000313|Proteomes:UP000467840}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. GT1 {ECO:0000313|Proteomes:UP000467840};
RC   TISSUE=Leaf {ECO:0000313|EMBL:KAF2306523.1};
RX   PubMed=31838037; DOI=10.1016/j.molp.2019.10.017;
RA   Liu J., Shi C., Shi C.C., Li W., Zhang Q.J., Zhang Y., Li K., Lu H.F.,
RA   Shi C., Zhu S.T., Xiao Z.Y., Nan H., Yue Y., Zhu X.G., Wu Y., Hong X.N.,
RA   Fan G.Y., Tong Y., Zhang D., Mao C.L., Liu Y.L., Hao S.J., Liu W.Q.,
RA   Lv M.Q., Zhang H.B., Liu Y., Hu-Tang G.R., Wang J.P., Wang J.H., Sun Y.H.,
RA   Ni S.B., Chen W.B., Zhang X.C., Jiao Y.N., Eichler E.E., Li G.H., Liu X.,
RA   Gao L.Z.;
RT   "The Chromosome-Based Rubber Tree Genome Provides New Insights into Spurge
RT   Genome Evolution and Rubber Biosynthesis.";
RL   Mol. Plant 13:336-350(2020).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2
CC         H2O; Xref=Rhea:RHEA:56136, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240,
CC         ChEBI:CHEBI:139520, ChEBI:CHEBI:139521; EC=1.11.1.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00000189};
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|PIRSR:PIRSR600823-3};
CC       Note=Binds 2 calcium ions per subunit. {ECO:0000256|PIRSR:PIRSR600823-
CC       3};
CC   -!- COFACTOR:
CC       Name=heme b; Xref=ChEBI:CHEBI:60344;
CC         Evidence={ECO:0000256|PIRSR:PIRSR600823-3};
CC       Note=Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
CC       {ECO:0000256|PIRSR:PIRSR600823-3};
CC   -!- SIMILARITY: Belongs to the peroxidase family. Ascorbate peroxidase
CC       subfamily. {ECO:0000256|ARBA:ARBA00006873}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KAF2306523.1}.
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DR   EMBL; JAAGAX010000008; KAF2306523.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A6A6M2E5; -.
DR   Proteomes; UP000467840; Chromosome 9.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0140825; F:lactoperoxidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0042744; P:hydrogen peroxide catabolic process; IEA:InterPro.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   CDD; cd00693; secretory_peroxidase; 2.
DR   Gene3D; 1.10.520.10; -; 2.
DR   Gene3D; 1.10.420.10; Peroxidase, domain 2; 2.
DR   InterPro; IPR002016; Haem_peroxidase.
DR   InterPro; IPR010255; Haem_peroxidase_sf.
DR   InterPro; IPR000823; Peroxidase_pln.
DR   InterPro; IPR019793; Peroxidases_heam-ligand_BS.
DR   InterPro; IPR033905; Secretory_peroxidase.
DR   PANTHER; PTHR31388:SF271; PEROXIDASE; 1.
DR   PANTHER; PTHR31388; PEROXIDASE 72-RELATED; 1.
DR   Pfam; PF00141; peroxidase; 2.
DR   PRINTS; PR00458; PEROXIDASE.
DR   PRINTS; PR00461; PLPEROXIDASE.
DR   SUPFAM; SSF48113; Heme-dependent peroxidases; 2.
DR   PROSITE; PS00435; PEROXIDASE_1; 2.
DR   PROSITE; PS50873; PEROXIDASE_4; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|PIRSR:PIRSR600823-3};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW   ECO:0000256|PIRSR:PIRSR600823-5}; Heme {ECO:0000256|ARBA:ARBA00022617};
KW   Iron {ECO:0000256|PIRSR:PIRSR600823-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR600823-3};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00022559};
KW   Peroxidase {ECO:0000256|ARBA:ARBA00022559};
KW   Reference proteome {ECO:0000313|Proteomes:UP000467840};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           26..503
FT                   /note="peroxidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5025454123"
FT   DOMAIN          35..503
FT                   /note="Plant heme peroxidase family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50873"
FT   BINDING         349
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600823-2"
FT   BINDING         379
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600823-3"
FT   BINDING         380
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600823-3"
FT   BINDING         424
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600823-3"
FT   BINDING         431
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600823-3"
FT   DISULFID        307..499
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600823-5"
FT   DISULFID        386..411
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600823-5"
SQ   SEQUENCE   503 AA;  54123 MW;  5DB40647C7834CCB CRC64;
     MASGGSVFYL SALIILAAAA ATVASSSLSP YYYDRGCDAS ILLDPSPTID SEKNARPNLN
     SARGFEVIDQ IKQAVDEVCG RPVVSCADIL AVVARDSVVA LGGPTWKVKL GRRDSTTASR
     TKADSDIPSP FMDLPALINN FKNQGLNERD LVALSGGHSI GFAQCFVFRN RIYSETNIDP
     KFAQQRRSTC PRNGGNSTLS PLDPTPARFD TAYFTNLIKK KGLLHSDQQL FNGGSTDGIV
     KTYSSNAKAF SADFARAVML QFFWILLPPL TVKRNALPNA NSARGFEVID QIKSEVDKAC
     GGAVVSCADI LAVVARDSVV ALGGPTWAVQ LGRRDSTTAS RTAAETDLPS PFADLPELIN
     GFKKQGLDEK DLVVLSGAHT LGFSKCGAFK NRIYNETNID PNFAQKRRST CPPNGGDGNL
     APLDPTPARF DLAYFTNLKN KKGLLHSDQQ LFNGGSTDNL VNTYSSNAPA FWNDFANSMV
     KMGNIKPLTG NQGQVRLNCK MVN
//
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