ID   A0A6G0T705_APHGL        Unreviewed;       220 AA.
AC   A0A6G0T705;
DT   12-AUG-2020, integrated into UniProtKB/TrEMBL.
DT   12-AUG-2020, sequence version 1.
DT   27-MAR-2024, entry version 9.
DE   RecName: Full=Deoxynucleoside kinase domain-containing protein {ECO:0000259|Pfam:PF01712};
GN   ORFNames=AGLY_013558 {ECO:0000313|EMBL:KAE9526910.1};
OS   Aphis glycines (Soybean aphid).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Paraneoptera; Hemiptera; Sternorrhyncha; Aphidomorpha;
OC   Aphidoidea; Aphididae; Aphidini; Aphis; Aphis.
OX   NCBI_TaxID=307491 {ECO:0000313|EMBL:KAE9526910.1, ECO:0000313|Proteomes:UP000475862};
RN   [1] {ECO:0000313|EMBL:KAE9526910.1, ECO:0000313|Proteomes:UP000475862}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Whole aphids {ECO:0000313|EMBL:KAE9526910.1};
RA   Giordano R., Donthu R.K., Hernandez A.G., Wright C.L., Zimin A.V.;
RT   "The genome of the soybean aphid Biotype 1, its phylome, world population
RT   structure and adaptation to the North American continent.";
RL   Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the DCK/DGK family.
CC       {ECO:0000256|ARBA:ARBA00007420}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KAE9526910.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; VYZN01000054; KAE9526910.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A6G0T705; -.
DR   OrthoDB; 5393913at2759; -.
DR   Proteomes; UP000475862; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0019136; F:deoxynucleoside kinase activity; IEA:InterPro.
DR   CDD; cd01673; dNK; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR002624; DCK/DGK.
DR   InterPro; IPR031314; DNK_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR10513; DEOXYNUCLEOSIDE KINASE; 1.
DR   PANTHER; PTHR10513:SF35; THYMIDINE KINASE 2, MITOCHONDRIAL; 1.
DR   Pfam; PF01712; dNK; 1.
DR   PIRSF; PIRSF000705; DNK; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PIRSR:PIRSR000705-3};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000705-3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000475862};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          11..200
FT                   /note="Deoxynucleoside kinase"
FT                   /evidence="ECO:0000259|Pfam:PF01712"
FT   ACT_SITE        90
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000705-1"
FT   BINDING         14..22
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000705-3"
FT   BINDING         149..153
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000705-3"
SQ   SEQUENCE   220 AA;  26198 MW;  D9E4A18457C53B88 CRC64;
     MQVVKKPFRV AIEGNVGSGK STLIKYFEKF KEVETNAEPI ETWRDLNGHN LLQLTYSDPH
     RWNFAFQHNV QLSRLNLQSK TTNKDIQMFE RSLQNNRYCF VEMAHDKGLL SSPEYGVMCQ
     WYEYIEANVD IGLDLIVYLR SLPDIVYTRM QRRNRPEERT VKLDYLVNLH EYYEKWLIKK
     YYNLPCSLLV IDVDKDLSEN QLIDLYQTYE DKILGKIPVL
//