ID A0A6G0YSS1_APHCR Unreviewed; 418 AA.
AC A0A6G0YSS1;
DT 12-AUG-2020, integrated into UniProtKB/TrEMBL.
DT 12-AUG-2020, sequence version 1.
DT 27-MAR-2024, entry version 12.
DE SubName: Full=Putative 28S rRNA (Cytosine-C(5))-methyltransferase {ECO:0000313|EMBL:KAF0760966.1};
GN ORFNames=FWK35_00008750 {ECO:0000313|EMBL:KAF0760966.1};
OS Aphis craccivora (Cowpea aphid).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Hemiptera; Sternorrhyncha; Aphidomorpha;
OC Aphidoidea; Aphididae; Aphidini; Aphis; Aphis.
OX NCBI_TaxID=307492 {ECO:0000313|EMBL:KAF0760966.1, ECO:0000313|Proteomes:UP000478052};
RN [1] {ECO:0000313|EMBL:KAF0760966.1, ECO:0000313|Proteomes:UP000478052}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=180601 {ECO:0000313|EMBL:KAF0760966.1};
RC TISSUE=Whole Body {ECO:0000313|EMBL:KAF0760966.1};
RA Voronova N.V., Shulinski R.S., Bandarenka Y.V., Zhorov D.G., Warner D.;
RT "Whole genome of Aphis craccivora.";
RL Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. RsmB/NOP family. {ECO:0000256|PROSITE-ProRule:PRU01023}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01023}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAF0760966.1}.
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DR EMBL; VUJU01002526; KAF0760966.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A6G0YSS1; -.
DR Proteomes; UP000478052; Unassembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR GO; GO:0001510; P:RNA methylation; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR049560; MeTrfase_RsmB-F_NOP2_cat.
DR InterPro; IPR001678; MeTrfase_RsmB-F_NOP2_dom.
DR InterPro; IPR049561; NSUN5_7_fdxn-like.
DR InterPro; IPR048889; NSUN5_RCM1_N.
DR InterPro; IPR023267; RCMT.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR22807:SF4; 28S RRNA (CYTOSINE-C(5))-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR22807; NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING; 1.
DR Pfam; PF01189; Methyltr_RsmB-F; 1.
DR Pfam; PF21148; NSUN5_fdxn-like; 1.
DR Pfam; PF21153; NSUN5_N; 1.
DR PRINTS; PR02008; RCMTFAMILY.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51686; SAM_MT_RSMB_NOP; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01023}; Reference proteome {ECO:0000313|Proteomes:UP000478052};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU01023};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01023};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01023}.
FT DOMAIN 88..394
FT /note="SAM-dependent MTase RsmB/NOP-type"
FT /evidence="ECO:0000259|PROSITE:PS51686"
FT ACT_SITE 326
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 227
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 254
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 270
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
SQ SEQUENCE 418 AA; 48260 MW; D4A2D6CD1578E457 CRC64;
MVINKLTLNA VLMNVFKWEK VIDVLVEKSN ILEKENNMDR DLVYVFITEM MWSKFGLKGN
AKNILAIKKY KNEFLKLMKE NDLEKLSGSK YTKVLKPRFF RVNTLMTTIE EILEKLLKLK
FKKLESPKSY AEFLELIKSD KFKPKNVFVQ DVHIKELLVF NSKVKFYELE EYNNGSLIVQ
DKASCLAAYL LNPEPNSTVL DMCAAPGMKT SHLAAIMQNK GKLYAVDRCK DRFNTMQKML
ERYMVQNVET FNMDALTFPY YDDVKYILLD PSCSGSGIVD RVRNDSSQQN QNFQMRLKKL
ANVHAQLLNH ALKSYPKLER LVYSTCSANH EENEAVVDEA LSVNGKFKLL DCTKIVKGWT
NKGVPGFDCS EMCLNAVPSD DCTNGFFIAV FVRRDLEEKV VVKEEKNIED IVVKEEKR
//
