ID A0A6G0YXP6_APHCR Unreviewed; 298 AA.
AC A0A6G0YXP6;
DT 12-AUG-2020, integrated into UniProtKB/TrEMBL.
DT 12-AUG-2020, sequence version 1.
DT 27-MAR-2024, entry version 10.
DE RecName: Full=Peptidyl-prolyl cis-trans isomerase E {ECO:0000256|ARBA:ARBA00021137, ECO:0000256|PIRNR:PIRNR001475};
DE Short=PPIase E {ECO:0000256|PIRNR:PIRNR001475};
DE EC=5.2.1.8 {ECO:0000256|ARBA:ARBA00013194, ECO:0000256|PIRNR:PIRNR001475};
GN ORFNames=FWK35_00007432 {ECO:0000313|EMBL:KAF0762927.1};
OS Aphis craccivora (Cowpea aphid).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Hemiptera; Sternorrhyncha; Aphidomorpha;
OC Aphidoidea; Aphididae; Aphidini; Aphis; Aphis.
OX NCBI_TaxID=307492 {ECO:0000313|EMBL:KAF0762927.1, ECO:0000313|Proteomes:UP000478052};
RN [1] {ECO:0000313|EMBL:KAF0762927.1, ECO:0000313|Proteomes:UP000478052}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=180601 {ECO:0000313|EMBL:KAF0762927.1};
RC TISSUE=Whole Body {ECO:0000313|EMBL:KAF0762927.1};
RA Voronova N.V., Shulinski R.S., Bandarenka Y.V., Zhorov D.G., Warner D.;
RT "Whole genome of Aphis craccivora.";
RL Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the cis-trans isomerization of proline imidic
CC peptide bonds in proteins. {ECO:0000256|PIRNR:PIRNR001475}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[protein]-peptidylproline (omega=180) = [protein]-
CC peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-
CC COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833,
CC ChEBI:CHEBI:83834; EC=5.2.1.8;
CC Evidence={ECO:0000256|ARBA:ARBA00000971,
CC ECO:0000256|PIRNR:PIRNR001475};
CC -!- SIMILARITY: Belongs to the cyclophilin-type PPIase family. PPIase E
CC subfamily. {ECO:0000256|ARBA:ARBA00009483,
CC ECO:0000256|PIRNR:PIRNR001475}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAF0762927.1}.
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DR EMBL; VUJU01002004; KAF0762927.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A6G0YXP6; -.
DR Proteomes; UP000478052; Unassembled WGS sequence.
DR GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006457; P:protein folding; IEA:InterPro.
DR CDD; cd01926; cyclophilin_ABH_like; 1.
DR CDD; cd12347; RRM_PPIE; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 2.40.100.10; Cyclophilin-like; 1.
DR InterPro; IPR029000; Cyclophilin-like_dom_sf.
DR InterPro; IPR020892; Cyclophilin-type_PPIase_CS.
DR InterPro; IPR002130; Cyclophilin-type_PPIase_dom.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR016304; PPIE.
DR InterPro; IPR034168; PPIE_RRM.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR11071; PEPTIDYL-PROLYL CIS-TRANS ISOMERASE; 1.
DR PANTHER; PTHR11071:SF561; PEPTIDYL-PROLYL CIS-TRANS ISOMERASE H; 1.
DR Pfam; PF00160; Pro_isomerase; 1.
DR Pfam; PF00076; RRM_1; 1.
DR PIRSF; PIRSF001475; PPI_cyclophilin_E; 1.
DR PRINTS; PR00153; CSAPPISMRASE.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF50891; Cyclophilin-like; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS00170; CSA_PPIASE_1; 1.
DR PROSITE; PS50072; CSA_PPIASE_2; 1.
DR PROSITE; PS50102; RRM; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|PIRNR:PIRNR001475};
KW Reference proteome {ECO:0000313|Proteomes:UP000478052};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176};
KW Rotamase {ECO:0000256|ARBA:ARBA00023110, ECO:0000256|PIRNR:PIRNR001475}.
FT DOMAIN 13..91
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 140..296
FT /note="PPIase cyclophilin-type"
FT /evidence="ECO:0000259|PROSITE:PS50072"
SQ SEQUENCE 298 AA; 33441 MW; 5D643465FE351764 CRC64;
MNDADTYKSY LKRTVYVGGL AEEVDDKVLR SAFIPFGDIV DVQMPLDYES EKHRGFAFVE
FEQPEDALDS IDNMNEAEIF GRTIRVNLAK PQKINRGSTR PVWSEDDWLV QYAGKTLEPK
DDKKIEEDKN KDEAKNPQVY LDIKIGKKDA GRIIIMLRAD IVPRTAENFR CLCTHEKGFG
YQNTTFHRII PNFMCQGGDI TNNNGTGGLS IYGKKFDDEN FELKHTGPGV LSMANSGPNT
NSSQFFICTA RTEWLDNKHV VFGHVLSGID VMKKIEKCGT KAGLPTEKVI IGSCGQLA
//
