ID   A0A6G1AZ03_CROCR        Unreviewed;       207 AA.
AC   A0A6G1AZ03;
DT   12-AUG-2020, integrated into UniProtKB/TrEMBL.
DT   12-AUG-2020, sequence version 1.
DT   22-FEB-2023, entry version 7.
DE   RecName: Full=Claudin {ECO:0000256|RuleBase:RU060637};
DE   Flags: Fragment;
GN   Name=Cldn11 {ECO:0000313|EMBL:KAF0880767.1};
GN   ORFNames=FOF47_R02072 {ECO:0000313|EMBL:KAF0880767.1};
OS   Crocuta crocuta (Spotted hyena).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Feliformia; Hyaenidae; Crocuta.
OX   NCBI_TaxID=9678 {ECO:0000313|EMBL:KAF0880767.1, ECO:0000313|Proteomes:UP000475037};
RN   [1] {ECO:0000313|EMBL:KAF0880767.1, ECO:0000313|Proteomes:UP000475037}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KB4526 {ECO:0000313|EMBL:KAF0880767.1};
RC   TISSUE=Muscle {ECO:0000313|EMBL:KAF0880767.1};
RA   Yang C., Li F.;
RL   Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a major role in tight junction-specific obliteration of
CC       the intercellular space, through calcium-independent cell-adhesion
CC       activity. {ECO:0000256|ARBA:ARBA00002246,
CC       ECO:0000256|RuleBase:RU060637}.
CC   -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC       {ECO:0000256|RuleBase:RU060637}. Cell membrane
CC       {ECO:0000256|RuleBase:RU060637}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU060637}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the claudin family.
CC       {ECO:0000256|ARBA:ARBA00008295, ECO:0000256|RuleBase:RU060637}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU060637}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KAF0880767.1}.
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DR   EMBL; VOAJ01003100; KAF0880767.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A6G1AZ03; -.
DR   Proteomes; UP000475037; Unassembled WGS sequence.
DR   GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   Gene3D; 1.20.140.150; -; 1.
DR   InterPro; IPR006187; Claudin.
DR   InterPro; IPR003555; Claudin11.
DR   InterPro; IPR017974; Claudin_CS.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   PANTHER; PTHR12002; CLAUDIN; 1.
DR   PANTHER; PTHR12002:SF6; CLAUDIN-11; 1.
DR   Pfam; PF00822; PMP22_Claudin; 1.
DR   PRINTS; PR01077; CLAUDIN.
DR   PRINTS; PR01384; CLAUDIN11.
DR   PROSITE; PS01346; CLAUDIN; 1.
PE   3: Inferred from homology;
KW   Cell junction {ECO:0000256|ARBA:ARBA00022949,
KW   ECO:0000256|RuleBase:RU060637};
KW   Cell membrane {ECO:0000256|RuleBase:RU060637};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU060637};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000475037};
KW   Tight junction {ECO:0000256|ARBA:ARBA00022427,
KW   ECO:0000256|RuleBase:RU060637};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU060637};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU060637}.
FT   TRANSMEM        83..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU060637"
FT   TRANSMEM        122..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU060637"
FT   TRANSMEM        161..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU060637"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KAF0880767.1"
FT   NON_TER         207
FT                   /evidence="ECO:0000313|EMBL:KAF0880767.1"
SQ   SEQUENCE   207 AA;  22022 MW;  89EC3E6104B1362C CRC64;
     MVATCLQVVG FVTSFVGWIG IIVTTSTNDW VVTCGYTIPT CRKLDELGSK GLWADCVMAT
     GLYHCKPLVD ILILPGYVQA CRALMIAASV LGLPAILLLL TVLPCIRMGH EPGVAKYRRA
     QLAGVMLILL ALCAIVATIW FPVCAHRETT IVSFGYSLYA GWIGAVLCLV GGCVIVCCAG
     DAQAFGENRF YYSSGSSSPT HAKSAHV
//