ID A0A6G1B9Y4_CROCR Unreviewed; 904 AA.
AC A0A6G1B9Y4;
DT 12-AUG-2020, integrated into UniProtKB/TrEMBL.
DT 12-AUG-2020, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE RecName: Full=P-type Ca(2+) transporter {ECO:0000256|ARBA:ARBA00012790};
DE EC=7.2.2.10 {ECO:0000256|ARBA:ARBA00012790};
DE Flags: Fragment;
GN Name=Atp2c2 {ECO:0000313|EMBL:KAF0884819.1};
GN ORFNames=FOF47_R16521 {ECO:0000313|EMBL:KAF0884819.1};
OS Crocuta crocuta (Spotted hyena).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Hyaenidae; Crocuta.
OX NCBI_TaxID=9678 {ECO:0000313|EMBL:KAF0884819.1, ECO:0000313|Proteomes:UP000475037};
RN [1] {ECO:0000313|EMBL:KAF0884819.1, ECO:0000313|Proteomes:UP000475037}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KB4526 {ECO:0000313|EMBL:KAF0884819.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:KAF0884819.1};
RA Yang C., Li F.;
RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + Ca(2+)(in) + H2O = ADP + Ca(2+)(out) + H(+) + phosphate;
CC Xref=Rhea:RHEA:18105, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:29108, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:456216; EC=7.2.2.10;
CC Evidence={ECO:0000256|ARBA:ARBA00024147};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18106;
CC Evidence={ECO:0000256|ARBA:ARBA00024147};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O + Mn(2+)(in) = ADP + H(+) + Mn(2+)(out) + phosphate;
CC Xref=Rhea:RHEA:66820, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:29035, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:456216; Evidence={ECO:0000256|ARBA:ARBA00024272};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66821;
CC Evidence={ECO:0000256|ARBA:ARBA00024272};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IIA subfamily. {ECO:0000256|ARBA:ARBA00005675}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAF0884819.1}.
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DR EMBL; VOAJ01001468; KAF0884819.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A6G1B9Y4; -.
DR Proteomes; UP000475037; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0005388; F:P-type calcium transporter activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 1.20.1110.10; Calcium-transporting ATPase, transmembrane domain; 2.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR006068; ATPase_P-typ_cation-transptr_C.
DR InterPro; IPR004014; ATPase_P-typ_cation-transptr_N.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR006413; P-type_ATPase_IIA_PMR1.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01522; ATPase-IIA2_Ca; 1.
DR NCBIfam; TIGR01494; ATPase_P-type; 2.
DR PANTHER; PTHR42861; CALCIUM-TRANSPORTING ATPASE; 1.
DR PANTHER; PTHR42861:SF23; CALCIUM-TRANSPORTING ATPASE TYPE 2C MEMBER 2; 1.
DR Pfam; PF13246; Cation_ATPase; 1.
DR Pfam; PF00689; Cation_ATPase_C; 1.
DR Pfam; PF00690; Cation_ATPase_N; 1.
DR Pfam; PF00122; E1-E2_ATPase; 2.
DR Pfam; PF00702; Hydrolase; 1.
DR PRINTS; PR00119; CATATPASE.
DR PRINTS; PR00120; HATPASE.
DR SFLD; SFLDS00003; Haloacid_Dehalogenase; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SMART; SM00831; Cation_ATPase_N; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Calcium {ECO:0000256|ARBA:ARBA00022568};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000475037};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022568}.
FT TRANSMEM 253..272
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 278..309
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 763..783
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 795..813
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 833..850
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 862..884
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 24..98
FT /note="Cation-transporting P-type ATPase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00831"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KAF0884819.1"
FT NON_TER 904
FT /evidence="ECO:0000313|EMBL:KAF0884819.1"
SQ SEQUENCE 904 AA; 97819 MW; 8EE3BD5E50A8132A CRC64;
QIDGHCELKA IEREKAVVAL SPKEASKCHR EDLAKAFYVD LQKGLSEFSV SQRRLVHGWN
EFVTDSAEPV WKKYLDQFKN PLTVLLLVSA LVSVLTKEYE DAVSIAAAVL IVVTVAFIQE
YRSEKSLEEL TKLVPPECNC IREGKLQHLL ARDLVPGDVV SLSTGDRIPA DIRLTEVRTS
LCVEGGARGT LPLSKLLPLT LRSASWVGTR VSGLGRLLSG SSRCPLLQRN GVLAICYPSP
HTSFQRLTPK PGAHGRALFV SFPGLIMFTG WLQGKQLLSM FTIGVSLAVA AIPEGLPIVV
TVTLVLGVLR MAKKRVIVKK LPIVETLGCC NVICSDKTGT LTANEMTVTQ LVTSDGLHAE
VSGVGYNGKG AVCLLPSKEV IKEFNNVSVG KLVEAGCAAN NAVIRKNAVI GQPTEGALLA
LAMKMDLGDI KDSYVRKKEI PFSSEQKWMA VKCSPKNEDQ EDIYFMKGAF EEVINYCTTY
NHGGISLPLT PQQRAFCQQE EKKMGSLGLR VLALASGPEL GRLTFLGLVG IIDPPRAGVK
EAMQVLCQSG VSVKMITGDA VETASAIGRS IGLCNGTLKA MSGEEVDSME PKELADHVGK
VSVFFRTSPK HKLKIIKALQ ESGAIVAMTG DGVNDAVALK SADIGIAMGQ AGTDVSKEAA
AMILVDDDFS AIMNAVEEGK GIFHNIKNFV RFQLSTSISA LSLITLSTVC KLPSPLNAMQ
ILWINIIMDG PPAQSSLGVE PVDDDALRQP PRNIKDTILS RALVLKTLLS AAVIISGTLF
IFWKEIPADK ASTPRTTTMT FTCFVFFDLF NALTCRSQTK LIFEIGFLRN PMFLYSVLGS
LLGQLAVIYI PPLQKVFQTE NLGALDLLLL TVLASSVFVF SELLKLCEKF CSRAGNAQTR
REDV
//
