ID   A0A6I4MTK8_9ACTN        Unreviewed;       309 AA.
AC   A0A6I4MTK8;
DT   12-AUG-2020, integrated into UniProtKB/TrEMBL.
DT   12-AUG-2020, sequence version 1.
DT   27-MAR-2024, entry version 13.
DE   SubName: Full=Dihydrodipicolinate synthase family protein {ECO:0000313|EMBL:MWA05646.1};
GN   ORFNames=F8568_035870 {ECO:0000313|EMBL:MWA05646.1};
OS   Actinomadura physcomitrii.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Thermomonosporaceae; Actinomadura.
OX   NCBI_TaxID=2650748 {ECO:0000313|EMBL:MWA05646.1, ECO:0000313|Proteomes:UP000462055};
RN   [1] {ECO:0000313|EMBL:MWA05646.1, ECO:0000313|Proteomes:UP000462055}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LD22 {ECO:0000313|EMBL:MWA05646.1,
RC   ECO:0000313|Proteomes:UP000462055};
RA   Zhuang X.;
RT   "Actinomadura physcomitrii sp. nov., a novel actinomycete isolated from
RT   moss [Physcomitrium sphaericum (Ludw) Fuernr].";
RL   Submitted (DEC-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the DapA family.
CC       {ECO:0000256|PIRNR:PIRNR001365}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:MWA05646.1}.
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DR   EMBL; WBMS02000040; MWA05646.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A6I4MTK8; -.
DR   Proteomes; UP000462055; Unassembled WGS sequence.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   CDD; cd00408; DHDPS-like; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002220; DapA-like.
DR   PANTHER; PTHR12128:SF74; BLL4423 PROTEIN; 1.
DR   PANTHER; PTHR12128; DIHYDRODIPICOLINATE SYNTHASE; 1.
DR   Pfam; PF00701; DHDPS; 1.
DR   PIRSF; PIRSF001365; DHDPS; 1.
DR   PRINTS; PR00146; DHPICSNTHASE.
DR   SMART; SM01130; DHDPS; 1.
DR   SUPFAM; SSF51569; Aldolase; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|PIRNR:PIRNR001365}.
FT   ACT_SITE        145
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT   ACT_SITE        173
FT                   /note="Schiff-base intermediate with substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
SQ   SEQUENCE   309 AA;  32919 MW;  738EE2CA0303BA2A CRC64;
     MSGTKLLSLG GVIVATALPY YEDATAPAGL AVDYDRYAEH CRWLVGNGCR GVGPNGSLGE
     YSSLTDEERR RVARTAIEAV GEDGVVVVGV HGPGSHQAKQ WAEYAAEDGA HGVLCLPPTM
     YRANRGEVIA HYEAVASAGL PVMVYNNPID TKVDLTPDLL AEIAQIDGIV AVKEFSGDVR
     RVLEIKEKAP GLEVVAGADD VTLEALLMGA TGWFAGFPNV FPAESALLYE LATAGKLEEA
     RALYEPLVAA FRWDSRTEFV QAIKLGMERV GRYGGPCRPP RGPLTGEHRA AVTADMSRAI
     EALAQRQAA
//