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Database: UniProt
Entry: A0A6I4MYK2_9ACTN
LinkDB: A0A6I4MYK2_9ACTN
Original site: A0A6I4MYK2_9ACTN 
ID   A0A6I4MYK2_9ACTN        Unreviewed;       361 AA.
AC   A0A6I4MYK2;
DT   12-AUG-2020, integrated into UniProtKB/TrEMBL.
DT   12-AUG-2020, sequence version 1.
DT   24-JAN-2024, entry version 8.
DE   RecName: Full=Prephenate dehydrogenase {ECO:0000256|ARBA:ARBA00016891};
DE            EC=1.3.1.12 {ECO:0000256|ARBA:ARBA00012068};
GN   ORFNames=E5671_13415 {ECO:0000313|EMBL:MWA10160.1};
OS   Streptomyces sp. BA2.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=436595 {ECO:0000313|EMBL:MWA10160.1, ECO:0000313|Proteomes:UP000431136};
RN   [1] {ECO:0000313|EMBL:MWA10160.1, ECO:0000313|Proteomes:UP000431136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BA2 {ECO:0000313|EMBL:MWA10160.1,
RC   ECO:0000313|Proteomes:UP000431136};
RA   Ince E.;
RT   "Complete genome sequence of Streptomyces sp. BA2.";
RL   Submitted (DEC-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=NAD(+) + prephenate = 3-(4-hydroxyphenyl)pyruvate + CO2 +
CC         NADH; Xref=Rhea:RHEA:13869, ChEBI:CHEBI:16526, ChEBI:CHEBI:29934,
CC         ChEBI:CHEBI:36242, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.3.1.12;
CC         Evidence={ECO:0000256|ARBA:ARBA00001162};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-
CC       hydroxyphenyl)pyruvate from prephenate (NAD(+) route): step 1/1.
CC       {ECO:0000256|ARBA:ARBA00005067}.
CC   -!- SIMILARITY: Belongs to the prephenate/arogenate dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00007964}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:MWA10160.1}.
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DR   EMBL; WSRO01000002; MWA10160.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A6I4MYK2; -.
DR   OrthoDB; 9802008at2; -.
DR   UniPathway; UPA00122; UER00961.
DR   Proteomes; UP000431136; Unassembled WGS sequence.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0008977; F:prephenate dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0006571; P:tyrosine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd02116; ACT; 1.
DR   Gene3D; 1.10.3660.10; 6-phosphogluconate dehydrogenase C-terminal like domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR046825; PDH_C.
DR   InterPro; IPR046826; PDH_N.
DR   InterPro; IPR003099; Prephen_DH.
DR   PANTHER; PTHR21363; PREPHENATE DEHYDROGENASE; 1.
DR   PANTHER; PTHR21363:SF0; PREPHENATE DEHYDROGENASE [NADP(+)]; 1.
DR   Pfam; PF20463; PDH_C; 1.
DR   Pfam; PF02153; PDH_N; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS51176; PDH_ADH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00023141};
KW   Aromatic amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023141};
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:MWA10160.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000431136};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Tyrosine biosynthesis {ECO:0000256|ARBA:ARBA00022498}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..361
FT                   /note="Prephenate dehydrogenase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5039693999"
FT   DOMAIN          2..283
FT                   /note="Prephenate/arogenate dehydrogenase"
FT                   /evidence="ECO:0000259|PROSITE:PS51176"
FT   DOMAIN          294..361
FT                   /note="ACT"
FT                   /evidence="ECO:0000259|PROSITE:PS51671"
SQ   SEQUENCE   361 AA;  37780 MW;  F08B936FB6316264 CRC64;
     MRTALVIGTG LIGTSAALAL ASRGVTVHLA DHDPGQARTA AALGAGTDEA PEGRVDLCVV
     AVPPAHVAAT LADVMRRDVA RGYLDVASVK GGPRRDLEAL GVDLTPYIGT HPMSGRERSG
     PLAGTADLFE GRPWVLTPTR DTDTEVLNLA LELVALCRAV PVVMDADAHD RAVALVSHMP
     HLVSSMVAAR LENAEETAVR LCGQGIRDVT RIAASDPRMW IDILSANPGP VADLLSAVAT
     DLDETVTALR ALQSADDVKR REGAAGVENV LRRGNAGQIR VPGKHGAAPA TYEVVAVLIN
     DQPGQLARIF ADADRAGVNI EDVRIEHATG QQAGLIQLLV VPKAAPVLAA ALRERGWAIR
     Q
//
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