ID   A0A6I5YQ28_9SPHN        Unreviewed;       343 AA.
AC   A0A6I5YQ28;
DT   12-AUG-2020, integrated into UniProtKB/TrEMBL.
DT   12-AUG-2020, sequence version 1.
DT   27-MAR-2024, entry version 10.
DE   RecName: Full=Dihydrodipicolinate synthase family protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=GL174_14825 {ECO:0000313|EMBL:QGP80412.1};
OS   Sphingobium sp. CAP-1.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Sphingobium.
OX   NCBI_TaxID=2676077 {ECO:0000313|EMBL:QGP80412.1, ECO:0000313|Proteomes:UP000426201};
RN   [1] {ECO:0000313|EMBL:QGP80412.1, ECO:0000313|Proteomes:UP000426201}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CAP-1 {ECO:0000313|EMBL:QGP80412.1,
RC   ECO:0000313|Proteomes:UP000426201};
RA   Ma X., Liang B., Wang A.;
RT   "A novel pathway for chloramphenicol metabolism in Sphingobium sp. CAP-1.";
RL   Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the DapA family.
CC       {ECO:0000256|PIRNR:PIRNR001365}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP046253; QGP80412.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A6I5YQ28; -.
DR   Proteomes; UP000426201; Chromosome min2.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   CDD; cd00408; DHDPS-like; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002220; DapA-like.
DR   PANTHER; PTHR12128:SF72; 4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR12128; DIHYDRODIPICOLINATE SYNTHASE; 1.
DR   Pfam; PF00701; DHDPS; 1.
DR   PIRSF; PIRSF001365; DHDPS; 1.
DR   PRINTS; PR00146; DHPICSNTHASE.
DR   SMART; SM01130; DHDPS; 1.
DR   SUPFAM; SSF51569; Aldolase; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|PIRNR:PIRNR001365};
KW   Reference proteome {ECO:0000313|Proteomes:UP000426201}.
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        166
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT   ACT_SITE        195
FT                   /note="Schiff-base intermediate with substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT   BINDING         236
FT                   /ligand="pyruvate"
FT                   /ligand_id="ChEBI:CHEBI:15361"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-2"
SQ   SEQUENCE   343 AA;  37666 MW;  0C299204A8A0DDB1 CRC64;
     MLTENPLPGA GPARARHEDK EDFTVSSAIS ADKIRGFIAP IPTVFDGKGE PDLPLIAQMA
     DFFLEAGVHG FFVLGSLGMG PVCTNEQRKA VAEAVIDRVA RRVPVMIQVG ATEPYSSMEL
     AAHAQAAGAD AIGVVGPYYF NNRTEWELIE HYRLIGTASD LPMLLYNNPL YSGYPCPPEL
     MVKIRNVVPT VFGGKLARGN PVEALRYIDV LGPDFTAFTP IEVVVPGVEL GVAGSIAAGP
     VAVVPELGVA LVEAAQNGEL DLAVKLQVAM LRYYRKQEYF WKTYGRGEYC EGWRLRGFDI
     VEYPRWPTPP MSEEDKRRYK ANMDDFFVEV EGLLGRKVRV AGR
//