ID A0A6I8NB21_ORNAN Unreviewed; 738 AA.
AC A0A6I8NB21;
DT 12-AUG-2020, integrated into UniProtKB/TrEMBL.
DT 12-AUG-2020, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE RecName: Full=peptidylprolyl isomerase {ECO:0000256|ARBA:ARBA00013194};
DE EC=5.2.1.8 {ECO:0000256|ARBA:ARBA00013194};
GN Name=PPIG {ECO:0000313|Ensembl:ENSOANP00000038216.1};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000038216.1, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000038216.1}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000038216.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[protein]-peptidylproline (omega=180) = [protein]-
CC peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-
CC COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833,
CC ChEBI:CHEBI:83834; EC=5.2.1.8;
CC Evidence={ECO:0000256|ARBA:ARBA00000971};
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DR AlphaFoldDB; A0A6I8NB21; -.
DR Ensembl; ENSOANT00000065484.1; ENSOANP00000038216.1; ENSOANG00000008535.5.
DR GeneTree; ENSGT00940000157954; -.
DR Proteomes; UP000002279; Unplaced.
DR Bgee; ENSOANG00000008535; Expressed in fibroblast and 8 other cell types or tissues.
DR GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006457; P:protein folding; IEA:InterPro.
DR Gene3D; 2.40.100.10; Cyclophilin-like; 1.
DR InterPro; IPR029000; Cyclophilin-like_dom_sf.
DR InterPro; IPR020892; Cyclophilin-type_PPIase_CS.
DR InterPro; IPR002130; Cyclophilin-type_PPIase_dom.
DR PANTHER; PTHR11071; PEPTIDYL-PROLYL CIS-TRANS ISOMERASE; 1.
DR PANTHER; PTHR11071:SF561; PEPTIDYL-PROLYL CIS-TRANS ISOMERASE H; 1.
DR Pfam; PF00160; Pro_isomerase; 1.
DR PRINTS; PR00153; CSAPPISMRASE.
DR SUPFAM; SSF50891; Cyclophilin-like; 1.
DR PROSITE; PS00170; CSA_PPIASE_1; 1.
DR PROSITE; PS50072; CSA_PPIASE_2; 1.
PE 4: Predicted;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Rotamase {ECO:0000256|ARBA:ARBA00023110}.
FT DOMAIN 11..161
FT /note="PPIase cyclophilin-type"
FT /evidence="ECO:0000259|PROSITE:PS50072"
FT REGION 167..738
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 182..200
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..234
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..293
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..331
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 332..350
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..435
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 449..550
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 551..565
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..581
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 593..738
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 738 AA; 86768 MW; 2B2992765612A646 CRC64;
MGIKVQRPRC FFDIAINNLP AGRVVFELFS DVCPKTCENF RCLCTGEKGT GKSTQKPLHY
KSCLFHRVVK DFMVQGGDFS EDESFAVKHN KEFLLSMANR GKDTNGSQFF ITTKPTPHLD
GHHVVFGQVI SGQEVVREIE NQKTDAASKP FAEVRILSCG ELIPKSKVKK EEKKRHKSSS
SSSDSESSSD SDSSSDSSSD SESASEEKSK KRKKKHKKNS RKHKKEKKKR KKNKRSSSSE
SEDENPEAQP LSTVRPEEIP PIPENRFLMR KSPPKVDEKE KKNREREKER ECNPSNSQAS
SYQRRLLVTR SGRKIKGRGP RRYRTPSRSR SRDRFRRSET PPHWRQEMQR AQRMRVSSGE
RWIKGDKSEM NENKKENQKS PGRGKERKMS DHRHASESPN RRSEKEKKTK DHKSNSKDRE
TRRNSEKDDK YNRSKAKKRG KSKSRSKSKE KSKSKERDSK HNRHEEKRMR SRSKERDHEK
EKEKDKHSDS RGRDREKSRS KERSKRAGSK SNEHDHTKNK DRDRHAKSRS REREQNKGKH
SSSSRTRERS RSRDRGRRGR SRSKERDRSR SKEYYRNRDK DSRRRGRSRS RERKRTPEKS
RSKESRRRRD SRSSEREESQ RRSKEKNRSY ESKSSHRKDN NENEKRRRSK SRDNSSPESN
KEKKADRDQS PSSRKIQNNK DRESKASGYK NKDKEKTRSS VEKEINQKSK SQERDQAHIK
DKKSDHESSP GTDEGKNG
//
