ID A0A6I8NVN6_ORNAN Unreviewed; 466 AA.
AC A0A6I8NVN6;
DT 12-AUG-2020, integrated into UniProtKB/TrEMBL.
DT 12-AUG-2020, sequence version 1.
DT 27-MAR-2024, entry version 13.
DE SubName: Full=ERBB receptor feedback inhibitor 1 {ECO:0000313|Ensembl:ENSOANP00000045011.1};
GN Name=ERRFI1 {ECO:0000313|Ensembl:ENSOANP00000045011.1};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000045011.1, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000045011.1, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000045011.1,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000045011.1}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000045011.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A6I8NVN6; -.
DR Ensembl; ENSOANT00000047124.1; ENSOANP00000045011.1; ENSOANG00000043417.1.
DR GeneTree; ENSGT00440000033870; -.
DR InParanoid; A0A6I8NVN6; -.
DR OMA; CWGSHSG; -.
DR OrthoDB; 5345626at2759; -.
DR Proteomes; UP000002279; Chromosome 5.
DR Bgee; ENSOANG00000043417; Expressed in liver and 8 other cell types or tissues.
DR GO; GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0045616; P:regulation of keratinocyte differentiation; IBA:GO_Central.
DR InterPro; IPR021619; Mig-6.
DR PANTHER; PTHR14254:SF5; ERBB RECEPTOR FEEDBACK INHIBITOR 1; 1.
DR PANTHER; PTHR14254; GENE 33 POLYPEPTIDE; 1.
DR Pfam; PF11555; Inhibitor_Mig-6; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002279}.
FT DOMAIN 319..342
FT /note="Mig-6"
FT /evidence="ECO:0000259|Pfam:PF11555"
FT REGION 224..376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..247
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 275..289
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 329..351
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 466 AA; 50681 MW; 5882737C80629F9E CRC64;
MSTAGVAAQE IRAPLKTGFL SNGQAMGNLK TCWNSHSEFE NNFFGIDSIS MAYSLNSTAQ
EHLTSIGPVS KSVPMSGHCC AENGFKAPTQ KSSLPPLIIP HSEHSGRHED EQIVSGFKKL
SINGSCASPR SPPLTPIKNG LSLFPLGAPG ERGSRPLPPL PISEDLSPDD TDCEVEFLTS
SDTDLLLEDC ALSVFKYGVP GRRSFRGCGQ INYAYFDTPA GSAVEDGSEA ADPNGCIQNS
NPLLPQNHRR LRRSHSGPAG SFHKPAIRIS SHLHRASPNS DEDKPEVPPR VPIPPRPVKP
DYRRWSAEVT SSTYSDEDRP PKVPPREPLS RSNSRTPSPK SLPSYLNGVM PPTQSFAPDP
KYVSSKALQR QNSEGSANKV PCILPIIENG KKVSSTHYYL LPERPPYLDK YEKFFREAEE
TGPGPQVQPW AGDCGVVSAP EKLDSKSKTD LGSHVKRKHL SYVVSP
//
