ID A0A6I8NVY3_ORNAN Unreviewed; 552 AA.
AC A0A6I8NVY3;
DT 12-AUG-2020, integrated into UniProtKB/TrEMBL.
DT 12-AUG-2020, sequence version 1.
DT 24-JAN-2024, entry version 12.
DE RecName: Full=Counting factor associated protein D {ECO:0008006|Google:ProtNLM};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000045080.1, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000045080.1}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000045080.1};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000256|ARBA:ARBA00004371}.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR AlphaFoldDB; A0A6I8NVY3; -.
DR Ensembl; ENSOANT00000056516.1; ENSOANP00000045080.1; ENSOANG00000040112.1.
DR GeneTree; ENSGT00940000163923; -.
DR OMA; GIMNMAK; -.
DR Proteomes; UP000002279; Unplaced.
DR Bgee; ENSOANG00000040112; Expressed in liver and 2 other cell types or tissues.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR PANTHER; PTHR12411:SF586; ZGC:110239; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Signal {ECO:0000256|SAM:SignalP};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..552
FT /note="Counting factor associated protein D"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5026014591"
FT DOMAIN 249..305
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 333..550
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 552 AA; 61762 MW; 339F63F6E6CF4EE5 CRC64;
MRTSRVGLLP WMLSLGLCHC LLAWSSPPDL APHSFGIIYH VSGVLSLPYA EVREPFEAWV
DLAGGRSRIQ YYHGQVVTYQ FSHERPFGVG YKVTPETTAA GENVRRCFRV NGTKAHPIRV
QSVLPNLEGF QVVGHEHLGG QKCSVLQNET HWGLRRNVYT LWLAGGPPGL RLPVRYAVRG
FSRLLGSHYD KYQLDYSNFS QHYSPEDVFS LPDRVPCGGV PSPEVKHHMQ VNPMWDFVAR
EEDRAHRLFE HFRHRHGRRY GDAAELEHRR RNFLHNLRFI DSHNRANRPF RLAPNHLTDR
TPGELAALRG RLRSSRPNHG QPFPHEQLAN VALPESLDWR LYGAVTPVKD QAVCGSCWSF
ATTGTLEGAL FLKTGELVPL SQQMLIDCSW DVGNFGCDGG LEWQAFDWIQ GHGGLASADS
YGPYEGQNGV CHSNTSTAAI RIVGYVNVPP ANPTALKLAL LRHGPVAVNV DASPRSFAFY
ANGIYYEPQC GHKLEQLNHA VLLVGYGVLQ GQAFWLLKNS WSPLWGNSGY MLLAMKDNDC
GVTTAATYPI LE
//