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Database: UniProt
Entry: A0A6I8NVY3_ORNAN
LinkDB: A0A6I8NVY3_ORNAN
Original site: A0A6I8NVY3_ORNAN 
ID   A0A6I8NVY3_ORNAN        Unreviewed;       552 AA.
AC   A0A6I8NVY3;
DT   12-AUG-2020, integrated into UniProtKB/TrEMBL.
DT   12-AUG-2020, sequence version 1.
DT   24-JAN-2024, entry version 12.
DE   RecName: Full=Counting factor associated protein D {ECO:0008006|Google:ProtNLM};
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000045080.1, ECO:0000313|Proteomes:UP000002279};
RN   [1] {ECO:0000313|Ensembl:ENSOANP00000045080.1}
RP   IDENTIFICATION.
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000045080.1};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000256|ARBA:ARBA00004371}.
CC   -!- SIMILARITY: Belongs to the peptidase C1 family.
CC       {ECO:0000256|ARBA:ARBA00008455}.
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DR   AlphaFoldDB; A0A6I8NVY3; -.
DR   Ensembl; ENSOANT00000056516.1; ENSOANP00000045080.1; ENSOANG00000040112.1.
DR   GeneTree; ENSGT00940000163923; -.
DR   OMA; GIMNMAK; -.
DR   Proteomes; UP000002279; Unplaced.
DR   Bgee; ENSOANG00000040112; Expressed in liver and 2 other cell types or tissues.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd02248; Peptidase_C1A; 1.
DR   Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR025661; Pept_asp_AS.
DR   InterPro; IPR000169; Pept_cys_AS.
DR   InterPro; IPR025660; Pept_his_AS.
DR   InterPro; IPR013128; Peptidase_C1A.
DR   InterPro; IPR000668; Peptidase_C1A_C.
DR   InterPro; IPR039417; Peptidase_C1A_papain-like.
DR   InterPro; IPR013201; Prot_inhib_I29.
DR   PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR   PANTHER; PTHR12411:SF586; ZGC:110239; 1.
DR   Pfam; PF08246; Inhibitor_I29; 1.
DR   Pfam; PF00112; Peptidase_C1; 1.
DR   PRINTS; PR00705; PAPAIN.
DR   SMART; SM00848; Inhibitor_I29; 1.
DR   SMART; SM00645; Pept_C1; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR   PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR   PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW   Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..552
FT                   /note="Counting factor associated protein D"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5026014591"
FT   DOMAIN          249..305
FT                   /note="Cathepsin propeptide inhibitor"
FT                   /evidence="ECO:0000259|SMART:SM00848"
FT   DOMAIN          333..550
FT                   /note="Peptidase C1A papain C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00645"
SQ   SEQUENCE   552 AA;  61762 MW;  339F63F6E6CF4EE5 CRC64;
     MRTSRVGLLP WMLSLGLCHC LLAWSSPPDL APHSFGIIYH VSGVLSLPYA EVREPFEAWV
     DLAGGRSRIQ YYHGQVVTYQ FSHERPFGVG YKVTPETTAA GENVRRCFRV NGTKAHPIRV
     QSVLPNLEGF QVVGHEHLGG QKCSVLQNET HWGLRRNVYT LWLAGGPPGL RLPVRYAVRG
     FSRLLGSHYD KYQLDYSNFS QHYSPEDVFS LPDRVPCGGV PSPEVKHHMQ VNPMWDFVAR
     EEDRAHRLFE HFRHRHGRRY GDAAELEHRR RNFLHNLRFI DSHNRANRPF RLAPNHLTDR
     TPGELAALRG RLRSSRPNHG QPFPHEQLAN VALPESLDWR LYGAVTPVKD QAVCGSCWSF
     ATTGTLEGAL FLKTGELVPL SQQMLIDCSW DVGNFGCDGG LEWQAFDWIQ GHGGLASADS
     YGPYEGQNGV CHSNTSTAAI RIVGYVNVPP ANPTALKLAL LRHGPVAVNV DASPRSFAFY
     ANGIYYEPQC GHKLEQLNHA VLLVGYGVLQ GQAFWLLKNS WSPLWGNSGY MLLAMKDNDC
     GVTTAATYPI LE
//
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