ID A0A6I8PEZ7_ORNAN Unreviewed; 648 AA.
AC A0A6I8PEZ7;
DT 12-AUG-2020, integrated into UniProtKB/TrEMBL.
DT 12-AUG-2020, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=ENTH domain-containing protein {ECO:0000259|PROSITE:PS50942};
GN Name=LOC100078315 {ECO:0000313|Ensembl:ENSOANP00000051191.1};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000051191.1, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000051191.1, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000051191.1,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000051191.1}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000051191.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PICALM/SNAP91 family.
CC {ECO:0000256|ARBA:ARBA00008011}.
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DR AlphaFoldDB; A0A6I8PEZ7; -.
DR Ensembl; ENSOANT00000063010.1; ENSOANP00000051191.1; ENSOANG00000001267.4.
DR GeneTree; ENSGT00950000183068; -.
DR Proteomes; UP000002279; Chromosome 6.
DR Bgee; ENSOANG00000001267; Expressed in fibroblast and 8 other cell types or tissues.
DR GO; GO:0030136; C:clathrin-coated vesicle; IEA:InterPro.
DR GO; GO:0005545; F:1-phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR GO; GO:0048268; P:clathrin coat assembly; IEA:InterPro.
DR GO; GO:0072583; P:clathrin-dependent endocytosis; IEA:InterPro.
DR CDD; cd16985; ANTH_N_AP180; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 1.20.58.150; ANTH domain; 1.
DR InterPro; IPR011417; ANTH_dom.
DR InterPro; IPR014712; ANTH_dom_sf.
DR InterPro; IPR045192; AP180-like.
DR InterPro; IPR013809; ENTH.
DR InterPro; IPR008942; ENTH_VHS.
DR PANTHER; PTHR22951; CLATHRIN ASSEMBLY PROTEIN; 1.
DR PANTHER; PTHR22951:SF11; ENTH DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF07651; ANTH; 1.
DR SMART; SM00273; ENTH; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF89009; GAT-like domain; 1.
DR PROSITE; PS50942; ENTH; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279}.
FT DOMAIN 14..145
FT /note="ENTH"
FT /evidence="ECO:0000259|PROSITE:PS50942"
FT REGION 516..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 318..345
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 648 AA; 70580 MW; 9B2DC88B5C0F572C CRC64;
MSGQSITDRI TAAQHSVTGS AVAKAVCKAT THEVMGPKKK HLDYLIQCTN EMNMNIPQLA
DTLFERTANS SWVVVFKALI TTHHLMMYGN ERFIQYLASR NTLFNLNNYL DKSAMQGYDM
STFIRRYSRY LNEKALSYRL VAVDFTKMKR GIDGVMRTMN TEKLLKTLPI IQNQLDALLD
FDANPNELTN GVINAAFMLL FKDSIRLFAA YNEGIINLLE KYFDMKKNQC REGLDIYKKF
LARMTKLSEF LKVAEQVGID QGDIPDLTQA PSSLLEALEQ HLASLEGKKT KEVSAASRAS
TLSSAVSTLA NTGMSFSRMD EKEKQQALEE EQARLQALKE QRLREISVVS NSASTTESPS
ALSGKSVNVT AAPAPTTNSM PNLSSDLFDL QPAFVPTVQS TPAIASSLGS AWGTDDFSAP
TAVYASVYPT VTSDGFPLRS TPQNPTASAI NVDFDAVFGA KSVAPEYGTT SDDVLQPTGA
ARGQRAAVQP GGKILANDLD SSLANLVGNL GFGGTPSKKS DMQWSQPSEK KLTGGTNWQA
KTSTSTTTWT PAPIPPAPHM VNVLTPGAVV SGIGKGCGRW GCVVRFDSSW ALSSLLGHCG
SGWPRSFSPR LSSRNRNEEV SSLPATIWRC YRGLLARMRT SLHLRAVL
//
