ID A0A6I8R0X4_XENTR Unreviewed; 448 AA.
AC A0A6I8R0X4;
DT 12-AUG-2020, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=Cathepsin F {ECO:0000313|Ensembl:ENSXETP00000074989, ECO:0000313|RefSeq:XP_031755640.1};
GN Name=ctsf {ECO:0000313|Ensembl:ENSXETP00000074989,
GN ECO:0000313|RefSeq:XP_031755640.1,
GN ECO:0000313|Xenbase:XB-GENE-5876529};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000074989};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000074989}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000074989};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000074989}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAY-2020) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_031755640.1}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_031755640.1};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_031755640.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR RefSeq; XP_031755640.1; XM_031899780.1.
DR Ensembl; ENSXETT00000070252; ENSXETP00000074989; ENSXETG00000017109.
DR Ensembl; ENSXETT00000123046; ENSXETP00000113098; ENSXETG00000017109.
DR Xenbase; XB-GENE-5876529; ctsf.
DR Proteomes; UP000008143; Chromosome 4.
DR Bgee; ENSXETG00000017109; Expressed in brain and 13 other cell types or tissues.
DR GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00042; CY; 1.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.10.450.10; -; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR000010; Cystatin_dom.
DR InterPro; IPR046350; Cystatin_sf.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411:SF444; CATHEPSIN F; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF00031; Cystatin; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00043; CY; 1.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54403; Cystatin/monellin; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT DOMAIN 6..116
FT /note="Cystatin"
FT /evidence="ECO:0000259|SMART:SM00043"
FT DOMAIN 151..208
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 235..446
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 448 AA; 50347 MW; E7EAC389ADA310C5 CRC64;
MLAFGHPPGR WTDVPSDAPE LKQVAEVAVR EFNRGNNGEE IYRQIRVTQA RKKVVSGLNY
DLTLILGRTQ CKKGQDFLLG SCLQTMSPPL MGVKCTFSIL IVPWMNETKI LHQLCSQEIF
IVELTDTETS QKQNVPSSEL EDEMLKTLTL FKDFVTTYNK KYSDQEEAAR RLQIFSQNLK
KAQMIQEMDQ GTAEYGVTKY SDLTEDEFRS LYLNPLLSSK PLYQMKKAIV PNMSAPDQWD
WRDHGAVTEV KNQGMCGSCW AFSVIGNIEG QWFLKKGSLV SLSEQELVDC DGVDHACAGG
LPSNAYEAIE KLGGIETEQE YSYEGHKNTC SFSTSKVSAY INSSVEIPKD ENEIAAWLAQ
NGPISIALNA FAMQFYRKGI SHPFRILCNP WMIDHAVLLV GYGERNGTPF WAIKNSWGTD
WGEQGYYYLY RGTGACGMNT MCSSAVVD
//
