ID A0A6I8RKZ5_XENTR Unreviewed; 629 AA.
AC A0A6I8RKZ5;
DT 02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 1.
DT 24-JAN-2024, entry version 11.
DE RecName: Full=Tetratricopeptide repeat protein 30 {ECO:0000256|RuleBase:RU367070};
GN Name=ttc30a {ECO:0000313|Ensembl:ENSXETP00000081421};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000081421};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000081421}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000081421};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000081421}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- FUNCTION: Required for polyglutamylation of axonemal tubulin. Plays a
CC role in anterograde intraflagellar transport (IFT), the process by
CC which cilia precursors are transported from the base of the cilium to
CC the site of their incorporation at the tip.
CC {ECO:0000256|RuleBase:RU367070}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC {ECO:0000256|ARBA:ARBA00004138, ECO:0000256|RuleBase:RU367070}.
CC -!- SIMILARITY: Belongs to the TTC30/dfy-1/fleer family.
CC {ECO:0000256|ARBA:ARBA00009522, ECO:0000256|RuleBase:RU367070}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A6I8RKZ5; -.
DR Ensembl; ENSXETT00000095996; ENSXETP00000081421; ENSXETG00000008469.
DR Xenbase; XB-GENE-1221159; ttc30a.
DR Bgee; ENSXETG00000008469; Expressed in testis and 13 other cell types or tissues.
DR GO; GO:0005879; C:axonemal microtubule; IEA:UniProtKB-UniRule.
DR GO; GO:0042073; P:intraciliary transport; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR039941; TT30.
DR PANTHER; PTHR20931:SF0; TETRATRICOPEPTIDE REPEAT PROTEIN 30; 1.
DR PANTHER; PTHR20931; UNCHARACTERIZED; 1.
DR Pfam; PF13174; TPR_6; 1.
DR SMART; SM00028; TPR; 4.
DR SUPFAM; SSF48452; TPR-like; 3.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273,
KW ECO:0000256|RuleBase:RU367070};
KW Cilium {ECO:0000256|ARBA:ARBA00023069, ECO:0000256|RuleBase:RU367070};
KW Cilium biogenesis/degradation {ECO:0000256|ARBA:ARBA00022794,
KW ECO:0000256|RuleBase:RU367070}; Coiled coil {ECO:0000256|SAM:Coils};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339,
KW ECO:0000256|RuleBase:RU367070}.
FT REPEAT 38..71
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT COILED 365..392
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 629 AA; 73244 MW; 4FC3FE9B65DB43ED CRC64;
VIQKPKHSNS HSFQIKEARY GEAIQILSNE LQKQYRSRAG LSLLGYCYYQ IQDFVNAADC
YEQLIQITPE VEEYKLYYAQ SLYKACMYPE AMKATFALDS SAYQSKMLKL QASIRYGEED
ISGAKSLVEQ MPSEDPESEI NMGCLLYKEG HYEEACKKFI TAMQVMGYKQ DLSYNIALCY
YSMKQYAPAL KHIADIIERG IREHPELGVG MTTEGIEVRS VGNTLVLHET ALIEAFNLKA
AIEYQLKNYE AAQEALTDMP PRSEEELDPV TLHNQALMNM DTKPTEGFEK LQFLLQQNPF
PPETFGNLLL LYCKYEYFDL AADVLAENAH LTYKFLTPYL YDFLDAMITC QTAPEEAFFK
LDELAGMLTE QMRKLTKQVQ EARHNRDDEA VKKAVNEYDE TLEKYIPVLM AQAKIYWNME
NYQMVEKIFR KSVEFCNEHD IWKLNVAHVL FMQDNKYKEA IGFYEPIVKK HYDNVKCNLC
AEELMRKIEK EEEQIAYENP DKKIYHLCIV NLVIGTLYCA KGNYEFGISR VIKSLEPYNK
KLGTDTWYHA KRCFLSLLEN MSKHMIMLRD DVIAECLQFL EHCEIYGRNI PAVIEQPLEE
ERMHIGKNTV TYESRQLKAL LYEITSWNL
//