ID A0A6I8RNU2_XENTR Unreviewed; 372 AA.
AC A0A6I8RNU2;
DT 02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=glutamine synthetase {ECO:0000256|ARBA:ARBA00012937};
DE EC=6.3.1.2 {ECO:0000256|ARBA:ARBA00012937};
GN Name=LOC100498257 {ECO:0000313|Ensembl:ENSXETP00000082311,
GN ECO:0000313|RefSeq:XP_031747972.1,
GN ECO:0000313|Xenbase:XB-GENE-29084119};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000082311};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000082311}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000082311};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000082311}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAY-2020) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_031747972.1}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_031747972.1};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_031747972.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the glutamine synthetase family.
CC {ECO:0000256|PROSITE-ProRule:PRU01331, ECO:0000256|RuleBase:RU000384}.
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DR RefSeq; XP_031747972.1; XM_031892112.1.
DR Ensembl; ENSXETT00000076273; ENSXETP00000082311; ENSXETG00000035576.
DR KEGG; xtr:100498257; -.
DR Xenbase; XB-GENE-29084119; LOC100498257.
DR OMA; VLCEAMK; -.
DR Proteomes; UP000008143; Chromosome 8.
DR Bgee; ENSXETG00000035576; Expressed in brain and 1 other cell type or tissue.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004356; F:glutamine synthetase activity; IEA:InterPro.
DR GO; GO:0006542; P:glutamine biosynthetic process; IEA:InterPro.
DR Gene3D; 3.10.20.70; Glutamine synthetase, N-terminal domain; 1.
DR Gene3D; 3.30.590.10; Glutamine synthetase/guanido kinase, catalytic domain; 1.
DR InterPro; IPR036651; Gln_synt_N_sf.
DR InterPro; IPR014746; Gln_synth/guanido_kin_cat_dom.
DR InterPro; IPR008146; Gln_synth_cat_dom.
DR PANTHER; PTHR20852; GLUTAMINE SYNTHETASE; 1.
DR PANTHER; PTHR20852:SF43; GLUTAMINE SYNTHETASE; 1.
DR Pfam; PF00120; Gln-synt_C; 1.
DR SMART; SM01230; Gln-synt_C; 1.
DR SUPFAM; SSF54368; Glutamine synthetase, N-terminal domain; 1.
DR SUPFAM; SSF55931; Glutamine synthetase/guanido kinase; 1.
DR PROSITE; PS51987; GS_CATALYTIC; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143}.
FT DOMAIN 116..372
FT /note="GS catalytic"
FT /evidence="ECO:0000259|PROSITE:PS51987"
SQ SEQUENCE 372 AA; 42473 MW; 8129C3D5E709FA80 CRC64;
MELGSHVSFS SSRLNRRVKD QYMKLPQEGK VMVTYVWKNV PHENLQCKTR TLDYEPKSIE
EIPKWGLAFH LQHEDPLRDM YLIPVKMFKD PFFWDPNKLV LCEAMKSNGQ PADNNLRQSC
KKVMEMARDY HPWFGMEQEY FLIGANGLPY GWQEDRCPIQ GIHHCGVGAD KVHGREIMEA
HYKACLYAGI KIWGTNAEII SSQWEFQVGP CEGTDAGDHL VMARFILHRV CEDFGVVASL
DPKPVPGFWA DSGCHVNFST EDMRKEGGLK HIEDAIEKLA KRHDHHISKY DPTGGEGNAQ
RLIGVLVTSN INKFSSGVDD RTASIRIPIQ VWQQGYGYLE DRRPSADCDP YAVIEAVVRT
TILKETTVYE EN
//
