ID A0A6I8SXV4_XENTR Unreviewed; 1002 AA.
AC A0A6I8SXV4;
DT 02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=MLLT10, histone lysine methyltransferase DOT1L cofactor {ECO:0000313|Ensembl:ENSXETP00000100076};
DE SubName: Full=Protein AF-10 isoform X6 {ECO:0000313|RefSeq:XP_012821094.1};
GN Name=mllt10 {ECO:0000313|Ensembl:ENSXETP00000100076,
GN ECO:0000313|RefSeq:XP_012821094.1,
GN ECO:0000313|Xenbase:XB-GENE-6408100};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000100076};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000100076}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000100076};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000100076}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAY-2020) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_012821094.1}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_012821094.1};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_012821094.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_012821094.1; XM_012965640.3.
DR Ensembl; ENSXETT00000075415; ENSXETP00000100076; ENSXETG00000007391.
DR GeneID; 100036598; -.
DR CTD; 8028; -.
DR Xenbase; XB-GENE-6408100; mllt10.
DR Proteomes; UP000008143; Chromosome 6.
DR Bgee; ENSXETG00000007391; Expressed in neurula embryo and 15 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd20901; CC_AF10; 1.
DR CDD; cd15708; ePHD_AF10; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR049773; AF10-like_CC.
DR InterPro; IPR049775; AF10_ePHD.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13793; PHD FINGER PROTEINS; 1.
DR PANTHER; PTHR13793:SF93; PROTEIN AF-10; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00249; PHD; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 57..176
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 112..175
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 259..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 336..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 407..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 503..537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 549..612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 742..796
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 676..713
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 275..318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 433..451
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 549..584
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1002 AA; 106964 MW; 4AC4F3A45D1ED83F CRC64;
MCSAAQSVGL DSLDRLPAGW QALDLGSYSR QACYGIVQVP TGPWFCRKCE SQERAARVRC
ELCPHKDGAL KRTDNGGWAH VVCALYIPEV QFANVSTMEP IVLQSVPHER YNKTCYICDE
QGRESKAATG ACMTCNKHGC RQAFHVTCAQ LAGLLCEEEG NGADNVQYCG YCKYHYSKLK
HKEKEKHRQK SRKQMEPLPA LVPSLTVTTE KTYTCSSSNN NNSVPSSVKR IEDTSARFTN
ANFQEVSTHP TSVKEALEAR SSEIKGKKAA SHITLQRGRK SSSGRNCAGS ATATSPFQQA
HFSGTPSSVK SSSGSSVQSP QEFLSFTEFE VRTESYHHSQ QLTSTKDAPK GDTGLQEGTI
NSFSSLIGLP TNPPLSFQTK NYESVPGDYV NSSLTVAGYK RLQSSVLDED TVKEKKRKGN
KQNKHGPGRP KGNKNQETLS HLSASSASPT SSVASAAGSI ASSVIQRSPT LLRNGSLQSL
SVGSSPGGSA SLCNCNDVPT SFPSALSGSS TPVSSSHIPQ PAAAHLQQEV SSSPSSLATV
PANTVATQVS SLPGSSLAMS SSHTYGRRLN PTSAAGTLPV PSENAQPDQD AVDHNRNLPA
KGASPRGSIS PRLNIYGVGS DKISPLNSLA TSRFEPSGNS SLESVPPAAT SIEQLLERQW
SEGQQFLQEQ GTSSDILGML KSLHQLQVEN RRLEEQIKNL TAKKERLQLL NAQLSVPFPT
ISSNPNTSPQ VHTYPLQNVS NSDSLNISKS PHLGNFQLDN ALPVPNQELT SSGQSTSSSS
SLSTPPPDGQ SPAQQVQGVH RINGVAMGAL TSGIQSVTQA LPNVASVGAI IGALPANQLS
INFGALNGVM QNPANLPQTA ALTHGSILPN VTHPITSSLA NSASGLGLLT DQQRQLLLHQ
QQQQFQHILN SQQLTPEQHH TFLYQLMQQH HQQQQQHHQP ELQQLQIPGA AQLPLNSLLA
GAQAAPLHST TTNPFLALHG DTAAQKVSRL GDKSGPVLQD KS
//
