ID   A0A6I8TVT8_AEDAE        Unreviewed;      1151 AA.
AC   A0A6I8TVT8;
DT   12-AUG-2020, integrated into UniProtKB/TrEMBL.
DT   12-AUG-2020, sequence version 1.
DT   24-JAN-2024, entry version 12.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:AAEL019507-PD};
GN   Name=5575390 {ECO:0000313|EnsemblMetazoa:AAEL019507-PD};
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159 {ECO:0000313|EnsemblMetazoa:AAEL019507-PD, ECO:0000313|Proteomes:UP000008820};
RN   [1] {ECO:0000313|EnsemblMetazoa:AAEL019507-PD, ECO:0000313|Proteomes:UP000008820}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL019507-PD,
RC   ECO:0000313|Proteomes:UP000008820};
RG   Aedes aegypti Genome Working Group (AGWG);
RA   Matthews B.J.;
RT   "Aedes aegypti genome working group (AGWG) sequencing and assembly.";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AAEL019507-PD}
RP   IDENTIFICATION.
RC   STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL019507-PD};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC         Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC         Evidence={ECO:0000256|ARBA:ARBA00034453};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   AlphaFoldDB; A0A6I8TVT8; -.
DR   EnsemblMetazoa; AAEL019507-RD; AAEL019507-PD; AAEL019507.
DR   InParanoid; A0A6I8TVT8; -.
DR   OrthoDB; 5490251at2759; -.
DR   Proteomes; UP000008820; Chromosome 3.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR   InterPro; IPR004841; AA-permease/SLC12A_dom.
DR   InterPro; IPR000076; KCL_cotranspt.
DR   InterPro; IPR018491; SLC12_C.
DR   InterPro; IPR004842; SLC12A_fam.
DR   NCBIfam; TIGR00930; 2a30; 1.
DR   PANTHER; PTHR11827:SF73; KAZACHOC, ISOFORM G; 1.
DR   PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR   Pfam; PF00324; AA_permease; 2.
DR   Pfam; PF03522; SLC12; 3.
DR   PRINTS; PR01081; KCLTRNSPORT.
PE   4: Predicted;
KW   Chloride {ECO:0000256|ARBA:ARBA00023214};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Potassium {ECO:0000256|ARBA:ARBA00022958};
KW   Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008820};
KW   Symport {ECO:0000256|ARBA:ARBA00022847};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Transport {ECO:0000256|ARBA:ARBA00022847}.
FT   DOMAIN          121..290
FT                   /note="Amino acid permease/ SLC12A"
FT                   /evidence="ECO:0000259|Pfam:PF00324"
FT   DOMAIN          400..678
FT                   /note="Amino acid permease/ SLC12A"
FT                   /evidence="ECO:0000259|Pfam:PF00324"
FT   DOMAIN          694..809
FT                   /note="SLC12A transporter C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03522"
FT   DOMAIN          821..936
FT                   /note="SLC12A transporter C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03522"
FT   DOMAIN          1082..1151
FT                   /note="SLC12A transporter C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03522"
SQ   SEQUENCE   1151 AA;  126700 MW;  83797DF007CFB879 CRC64;
     MAEDCDKAPV TNKGGDVEKA ASKQASPAPQ LKAAGGTGAA AASPNKAATG GTGEPTDEQP
     FVSKDGKVGA NLYLYSEEIQ ERPQITTLIS SLANYSNTIP AATDPDAKPA QPSARMGTLI
     GVFLPCIQNI FGVILFIRLT WVVGTAGAIF GFLIVLCCCC VTMLTAISMS AIATNGVVPA
     GGSYFMISRS LGPEFGGAVG MLFYTGTTLA AAMYIVGAVE IVLTYMAPWL SIFGDFTKDA
     SAMYNNFRVY GTGLLCVMGL IVYLGVKFVN KFATVALACV IFSIIAVYAG IFNNIDGNDK
     LFMCVLGKRL LRDIAVDNCT KEVGGPLYNT FCEGGECDPY FTEHNVSLVR GIKGLKSGVF
     FDNIFPSFLQ EGQFIAYGLD PEHIEPLDRP SYNQVYADCT TAFTILIGIF FPSVTGIMAG
     SNRSGDLADA QKSIPIGTIG AILTTSTVYL SCVMLFAGTV DNLLLRDKFG QSIGGKLVVA
     NMAWPNQWVI LIGSFLSTLG AGLQSLTGAP RLLQAIARDG IIPFLEPFAV SSKRGEPTRA
     LILTLLICQS GILLGNVDLL APLLSMFFLM CYGFVNLACA VQTLLRTPNW RPRFKFYHWS
     LSLIGLTLCM SIMFMTSWYF ALIAMGMAVL IYKYIEYRGA EKEWGDGIRG IALSAARYSL
     LRLEEGPPHT KNWRPQILML AKLNDDYTPK YRKLFSLVSQ LKAGKGLVVV VSLIQGDFTK
     RAGEAAAAKQ SLRKLMEDEK VKGFCDVMVA SNVADGLSHV VQTIGLGGMK PNTVILGWPY
     GWRQSEDDRT WHVFLQTVRN VSAARMALLV PKGINFFPTS QDKKISGNID IWWIVHDGGL
     LMLLPFLLKQ HRSWKNCKMR IFTVAQMEDN SIQIKKDLKM FLYHLRIEAE VEVVEMMDSD
     ISAYTYERTL MMEQRNQMLR KLRLNKREKE NVVENIVDFN QGAANGEDRT PLNSKEEELK
     EFVFSTVQAI VDHHHHIENN TKTASKVRFA DPAENKDIFN DDDREEKHET ESEKDKDTKE
     SENDNDANNE NSEKKEQQQS PQPVANNVAS PGKDSKKSAA GDETPKSPSK ANYKPDEGNV
     RRMHTAVKLN EVIVNKSHDA QLVILNLPGP PKETHVERES NYMEFLEVLT EGLERVLMVR
     GGGREVITIY S
//