ID A0A6I8V1F2_DROPS Unreviewed; 338 AA.
AC A0A6I8V1F2;
DT 12-AUG-2020, integrated into UniProtKB/TrEMBL.
DT 12-AUG-2020, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=Cathepsin L1 {ECO:0000313|RefSeq:XP_002134852.2};
GN Name=LOC6900459 {ECO:0000313|RefSeq:XP_002134852.2};
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245 {ECO:0000313|Proteomes:UP000001819, ECO:0000313|RefSeq:XP_002134852.2};
RN [1] {ECO:0000313|RefSeq:XP_002134852.2}
RP IDENTIFICATION.
RC STRAIN=MV2-25 {ECO:0000313|RefSeq:XP_002134852.2};
RC TISSUE=Whole body {ECO:0000313|RefSeq:XP_002134852.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR RefSeq; XP_002134852.2; XM_002134816.3.
DR AlphaFoldDB; A0A6I8V1F2; -.
DR KEGG; dpo:6900459; -.
DR InParanoid; A0A6I8V1F2; -.
DR Proteomes; UP000001819; Chromosome X.
DR ExpressionAtlas; A0A6I8V1F2; baseline.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR PANTHER; PTHR12411:SF642; PRO-CATHEPSIN H; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001819};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..338
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5026254114"
FT DOMAIN 31..89
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 120..337
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 338 AA; 37916 MW; E38FB1C6AE125C9E CRC64;
MNLPRSYLGF HLLLLLLGIA CATARVSMAE WNAFKEKYGK RYNYNDNIRH YGIYKRRALE
VQEHNIRFAA GEVGYEMGLN EFSDTKQNLL AFRTNGAEPE ADAPTQNLTI PSNYKYYDQI
TEGKDWRESG CISPVGNQGT ECLACWAFAA SGAIEAHLAL KNHRLVELSP KHLLDCTNRP
SAKCEGGWVS VAFNYTRDNG IATKESYPFV PLSEECRYDK STSAGRVRGY VTLSNADERE
LAEVVYNIGP VAVSIDHLQQ SFRNYKRGVL KDENCRSNRA SLRHAVLVVG FGTDAEWGDY
WLIKNSYGTS WGIDGYFKLA RNAGNMCGVA SIPQYPLV
//