ID   A0A6I8VYX2_DROPS        Unreviewed;      1082 AA.
AC   A0A6I8VYX2;
DT   12-AUG-2020, integrated into UniProtKB/TrEMBL.
DT   12-AUG-2020, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   SubName: Full=Nardilysin {ECO:0000313|RefSeq:XP_033235724.1};
GN   Name=LOC6902933 {ECO:0000313|RefSeq:XP_033235724.1};
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245 {ECO:0000313|Proteomes:UP000001819, ECO:0000313|RefSeq:XP_033235724.1};
RN   [1] {ECO:0000313|RefSeq:XP_033235724.1}
RP   IDENTIFICATION.
RC   STRAIN=MV2-25 {ECO:0000313|RefSeq:XP_033235724.1};
RC   TISSUE=Whole body {ECO:0000313|RefSeq:XP_033235724.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase M16 family.
CC       {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
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DR   RefSeq; XP_033235724.1; XM_033379833.1.
DR   AlphaFoldDB; A0A6I8VYX2; -.
DR   KEGG; dpo:6902933; -.
DR   InParanoid; A0A6I8VYX2; -.
DR   Proteomes; UP000001819; Chromosome 4.
DR   ExpressionAtlas; A0A6I8VYX2; baseline.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR001431; Pept_M16_Zn_BS.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   InterPro; IPR032632; Peptidase_M16_M.
DR   PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR   PANTHER; PTHR43690; NARDILYSIN; 1.
DR   Pfam; PF00675; Peptidase_M16; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 2.
DR   Pfam; PF16187; Peptidase_M16_M; 1.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR   PROSITE; PS00143; INSULINASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001819};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          98..223
FT                   /note="Peptidase M16 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00675"
FT   DOMAIN          253..424
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
FT   DOMAIN          445..729
FT                   /note="Peptidase M16 middle/third"
FT                   /evidence="ECO:0000259|Pfam:PF16187"
FT   DOMAIN          734..916
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
SQ   SEQUENCE   1082 AA;  124622 MW;  6F74000BD89D795D CRC64;
     MVLKMCFEPR HSLRIITNKV YKWVNRTFQT TVQYHEPPDK SDGDKKLYRA LSLSNGLRAM
     LISDPTNNME HTQDVRHHLP TVGDSGSEWS NPSMEHFNGK LAACAVLVSV GSFSEPRQYQ
     GMAHFLEHMI FMGSEKYPIE NEFDAFITKN GGFTNAHTEN EETCFYFEVE EAHLDKGMDI
     FMNLIRAPLL LPDAMARERS AVQSEFEQVY MRDEVRRDQI LASLASDEYP HGTFSWGNLA
     SLQDQVDDRL LQEALHEFRR KHYGSNRMIV CIQSQQSLDE LEALLVRHCA DIPNSQENAS
     DMNSLSYQKA FNETLFSDVI LVQPVEDVCK LELTWVLPPM RHQYRCKPDA FLSQLIGYEG
     VGSLCSYLRR RLWCMSVMAG TGGSSFESNS IYSLFNICIY LTDDGFEHID EVLEATFAWI
     KLLNESAHHR EDSYKEFQQI AANNFRFEIE LPSMDNVQRV VEGISYLPPK DVLTGPNLYF
     EFDPAAMVLL KKNLSEFHFN IMISSHIPYM DHKYDQREKW FGTQYTTISM PSKWKAMWYD
     PAPLNELTFP QSNPFITTDF TLHWQEAGRP HIPRHPRALI RDDYCELWFR QDDIFQLPDG
     FINIYFITPL IRESAKNYMV GVLFTYLVEF SIAEQLYPAL EAGLSYGLYI GDKGLVLRVS
     GYSQKLPLLL EIIMKVMSTL ELDPAQVISF KDLKKRQIFS ALFSGKILNL DLRLMVLENK
     RFSMLEKYES IDHITVDDIQ HFKENFHKKM YVQGLIQGNF TDEQARAAMQ QVLSTYESQK
     LDNPSSLDDS LVQIPLGSHY LRAKALNHRD TNTIVTNYYQ IGPSDLKLEC LMDLVELIVE
     EPFFNQLRTQ EQLGYSLSLN QRIGYGVLAC VITVNTQETK HSADHVDRRI EAFRSRVPEL
     VDQLSETEFD DVRETLISGK RLGEPSLDEE VMRNWSEIVT SEYFFDRKEK QIKTLNGLTK
     RDVLDLLLDF ESNNFRKLSV QVIGRNRPPS RPLTLPISEA VAGRLVSEPG NAQSGSLLSL
     LEEVQRNISD EQLLYEQTGS NIKIELIGNG EDATHIVDIP AFKKNLHVYP PFITNPKSNR
     KS
//